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    HTR1B 5-hydroxytryptamine receptor 1B [ Canis lupus familiaris (dog) ]

    Gene ID: 403741, updated on 2-Oct-2018

    Summary

    Gene symbol
    HTR1B
    Gene description
    5-hydroxytryptamine receptor 1B
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Annotation information
    Annotation category: partial on reference assembly
    Orthologs

    Genomic context

    See HTR1B in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    105 current CanFam3.1 (GCF_000002285.3) 12 NC_006594.3 (38659088..38659546, complement)

    Chromosome 12 - NC_006594.3Genomic Context describing neighboring genes Neighboring gene 60S acidic ribosomal protein P0 pseudogene Neighboring gene nucleolar protein of 40 kDa pseudogene Neighboring gene uncharacterized LOC111098172 Neighboring gene ATPase ASNA1 pseudogene Neighboring gene meiotic double-stranded break formation protein 4

    Genomic regions, transcripts, and products

    Genomic Sequence:
    NC_006594.3 Chromosome 12 Reference CanFam3.1 Primary Assembly

    Pathways from BioSystems

    • Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
      Neuroactive ligand-receptor interaction, organism-specific biosystem
      Neuroactive ligand-receptor interaction
    • Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
      Neuroactive ligand-receptor interaction, conserved biosystem
      Neuroactive ligand-receptor interaction
    • Serotonergic synapse, organism-specific biosystem (from KEGG)
      Serotonergic synapse, organism-specific biosystemSerotonin (5-Hydroxytryptamine, 5-HT) is a monoamine neurotransmitter that plays important roles in physiological functions such as learning and memory, emotion, sleep, pain, motor function and endoc...
    • Taste transduction, organism-specific biosystem (from KEGG)
      Taste transduction, organism-specific biosystemFive basic tastes are recognized by humans and most other animals - bitter, sweet, sour, salty and umami. In vertebrates, taste stimuli are detected by taste receptor cells (TRCs). At least three dis...
    • Taste transduction, conserved biosystem (from KEGG)
      Taste transduction, conserved biosystemFive basic tastes are recognized by humans and most other animals - bitter, sweet, sour, salty and umami. In vertebrates, taste stimuli are detected by taste receptor cells (TRCs). At least three dis...
    • cAMP signaling pathway, organism-specific biosystem (from KEGG)
      cAMP signaling pathway, organism-specific biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
    • cAMP signaling pathway, conserved biosystem (from KEGG)
      cAMP signaling pathway, conserved biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    G protein-coupled serotonin receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    adenylate cyclase-inhibiting serotonin receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    behavior IEA
    Inferred from Electronic Annotation
    more info
     
    bone remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to alkaloid ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cellular response to drug ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of serotonin secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of behavior IEA
    Inferred from Electronic Annotation
    more info
     
    vasoconstriction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    integral component of plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    5-hydroxytryptamine receptor 1B
    Names
    5-HT-1B
    5-HT1B
    5-HT1D beta
    5-HT1D subtype beta
    5-HTR1B
    5-Hydroxytryptamine 1D receptor subtype beta
    serotonin receptor 1B

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001006948.1NP_001006949.1  5-hydroxytryptamine receptor 1B

      See identical proteins and their annotated locations for NP_001006949.1

      Status: PROVISIONAL

      Source sequence(s)
      AB193090
      UniProtKB/Swiss-Prot
      P79250
      Conserved Domains (2) summary
      pfam00001
      Location:66368
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:63185
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 105 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference CanFam3.1 Primary Assembly

    Genomic

    1. NC_006594.3 Reference CanFam3.1 Primary Assembly

      Range
      38659088..38659546 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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