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    araf.S A-Raf proto-oncogene, serine/threonine kinase S homeolog [ Xenopus laevis (African clawed frog) ]

    Gene ID: 399056, updated on 8-Apr-2017

    Summary

    Symbol
    araf.S
    Full Name
    A-Raf proto-oncogene, serine/threonine kinase S homeolog
    Primary source
    Xenbase:XB-GENE-6254640
    Locus tag
    XELAEV_18041406mg
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus laevis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
    Also known as
    araf; pks2; a-raf; araf1; rafa1; araf-a; araf-b

    Genomic context

    See araf.S in Genome Data Viewer
    Location:
    chromosome: 8S
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    100 current Xenopus_laevis_v2 (GCF_001663975.1) 8S NC_030739.1 (26292289..26301957, complement)

    Chromosome 8S - NC_030739.1Genomic Context describing neighboring genes Neighboring gene transcription cofactor vestigial-like protein 4 Neighboring gene metalloproteinase inhibitor 1-like Neighboring gene synapsin I S homeolog Neighboring gene uncharacterized LOC108699854 Neighboring gene zinc finger protein 618 S homeolog

    Genomic regions, transcripts, and products

    Genomic Sequence:
    NC_030739.1 Chromosome 8S Reference Xenopus_laevis_v2 Primary Assembly

    Bibliography

    Related articles in PubMed

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • ErbB signaling pathway, organism-specific biosystem (from KEGG)
      ErbB signaling pathway, organism-specific biosystemThe ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including prolife...
    • ErbB signaling pathway, conserved biosystem (from KEGG)
      ErbB signaling pathway, conserved biosystemThe ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including prolife...
    • FoxO signaling pathway, organism-specific biosystem (from KEGG)
      FoxO signaling pathway, organism-specific biosystemThe forkhead box O (FOXO) family of transcription factors regulates the expression of genes in cellular physiological events including apoptosis, cell-cycle control, glucose metabolism, oxidative str...
    • Insulin signaling pathway, organism-specific biosystem (from KEGG)
      Insulin signaling pathway, organism-specific biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
    • Insulin signaling pathway, conserved biosystem (from KEGG)
      Insulin signaling pathway, conserved biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
    • MAPK (ERK1/2) signaling, organism-specific biosystem (from KEGG)
      MAPK (ERK1/2) signaling, organism-specific biosystemFunctional set; Cellular processes; Cell signaling
    • MAPK (ERK1/2) signaling, conserved biosystem (from KEGG)
      MAPK (ERK1/2) signaling, conserved biosystemFunctional set; Cellular processes; Cell signaling
    • Progesterone-mediated oocyte maturation, organism-specific biosystem (from KEGG)
      Progesterone-mediated oocyte maturation, organism-specific biosystemXenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division c...
    • Progesterone-mediated oocyte maturation, conserved biosystem (from KEGG)
      Progesterone-mediated oocyte maturation, conserved biosystemXenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division c...
    • Regulation of actin cytoskeleton, organism-specific biosystem (from KEGG)
      Regulation of actin cytoskeleton, organism-specific biosystem
      Regulation of actin cytoskeleton
    • Regulation of actin cytoskeleton, conserved biosystem (from KEGG)
      Regulation of actin cytoskeleton, conserved biosystem
      Regulation of actin cytoskeleton
    • Vascular smooth muscle contraction, organism-specific biosystem (from KEGG)
      Vascular smooth muscle contraction, organism-specific biosystemThe vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regula...
    • Vascular smooth muscle contraction, conserved biosystem (from KEGG)
      Vascular smooth muscle contraction, conserved biosystemThe vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regula...

    General protein information

    Preferred Names
    A-Raf proto-oncogene, serine/threonine kinase S homeolog
    Names
    serine/threonine protein kinase ARAF
    v-raf murine sarcoma 3611 viral oncogene homolog

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001090207.1NP_001083676.1  A-Raf proto-oncogene, serine/threonine kinase S homeolog

      See identical proteins and their annotated locations for NP_001083676.1

      Status: PROVISIONAL

      Source sequence(s)
      BC072170
      UniProtKB/TrEMBL
      Q6INV2
      Conserved Domains (4) summary
      cd01816
      Location:2798
      Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
      cd00029
      Location:106151
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      pfam00069
      Location:304558
      Pkinase; Protein kinase domain
      cl21453
      Location:301565
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 100 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_laevis_v2 Primary Assembly

    Genomic

    1. NC_030739.1 Reference Xenopus_laevis_v2 Primary Assembly

      Range
      26292289..26301957 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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