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    SIGLEC1 sialic acid binding Ig like lectin 1 [ Sus scrofa (pig) ]

    Gene ID: 397623, updated on 2-Oct-2018

    Summary

    Gene symbol
    SIGLEC1
    Gene description
    sialic acid binding Ig like lectin 1
    See related
    Ensembl:ENSSSCG00000007146
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae; Sus
    Also known as
    SA; SN; pSn; p210; SIGLEC-1
    Expression
    Biased expression in lung (RPKM 34.5), spleen (RPKM 30.0) and 4 other tissues See more
    Orthologs

    Genomic context

    See SIGLEC1 in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 17 NC_010459.5 (31994505..32021239)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) 17 NC_010459.4 (36328314..36347405)

    Chromosome 17 - NC_010459.5Genomic Context describing neighboring genes Neighboring gene chromosome 17 C20orf27 homolog Neighboring gene sperm flagellar 1 Neighboring gene heat shock protein family A (Hsp70) member 12B Neighboring gene ADAM metallopeptidase domain 33 Neighboring gene GDNF family receptor alpha 4

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
      Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
      Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...

    General gene information

    Homology

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    virion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    virus receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    clathrin-dependent endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    clathrin-dependent endocytosis of virus by host cell IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of phagocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    viral entry into host cell IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    early endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endocytic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    late endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT lysosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT plasma membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    sialoadhesin
    Names
    Sialic acid-binding Ig-like lectin 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_214346.1NP_999511.1  sialoadhesin precursor

      See identical proteins and their annotated locations for NP_999511.1

      Status: PROVISIONAL

      Source sequence(s)
      AF509585
      UniProtKB/Swiss-Prot
      A7LCJ3
      UniProtKB/TrEMBL
      J9S2W1
      Conserved Domains (7) summary
      cd00096
      Location:10041079
      Ig; Immunoglobulin domain
      smart00408
      Location:14581519
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:10041079
      IG; Immunoglobulin
      smart00410
      Location:516594
      IG_like; Immunoglobulin like
      pfam07679
      Location:897979
      I-set; Immunoglobulin I-set domain
      pfam13895
      Location:514594
      Ig_2; Immunoglobulin domain
      cl11960
      Location:21136
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010459.5 Reference Sscrofa11.1 Primary Assembly

      Range
      31994505..32021239
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021077303.1XP_020932962.1  sialoadhesin isoform X1

      Related
      ENSSSCP00000034728.1, ENSSSCT00000035867.2
      Conserved Domains (8) summary
      smart00408
      Location:254312
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:10041079
      IG; Immunoglobulin
      smart00410
      Location:10921149
      IG_like; Immunoglobulin like
      pfam13895
      Location:338408
      Ig_2; Immunoglobulin domain
      pfam13927
      Location:710774
      Ig_3; Immunoglobulin domain
      cd00096
      Location:13631437
      Ig; Immunoglobulin domain
      cl11960
      Location:21136
      Ig; Immunoglobulin domain
      cl28434
      Location:806892
      I-set; Immunoglobulin I-set domain
    2. XM_021077304.1XP_020932963.1  sialoadhesin isoform X2

      Conserved Domains (8) summary
      smart00408
      Location:254312
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:10031078
      IG; Immunoglobulin
      smart00410
      Location:10911148
      IG_like; Immunoglobulin like
      pfam13895
      Location:338408
      Ig_2; Immunoglobulin domain
      pfam13927
      Location:709773
      Ig_3; Immunoglobulin domain
      cd00096
      Location:13621436
      Ig; Immunoglobulin domain
      cl11960
      Location:21136
      Ig; Immunoglobulin domain
      cl28434
      Location:805891
      I-set; Immunoglobulin I-set domain
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