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    TLR8 toll like receptor 8 [ Sus scrofa (pig) ]

    Gene ID: 397384, updated on 8-Dec-2018

    Summary

    Gene symbol
    TLR8
    Gene description
    toll like receptor 8
    See related
    Ensembl:ENSSSCG00000012118
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae; Sus
    Also known as
    TLR7
    Expression
    Biased expression in spleen (RPKM 29.8), lung (RPKM 8.2) and 1 other tissue See more
    Orthologs

    Genomic context

    See TLR8 in Genome Data Viewer
    Location:
    X; X
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) X NC_010461.5 (9551284..9616762)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) X NC_010461.4 (10451110..10512940)

    Chromosome X - NC_010461.5Genomic Context describing neighboring genes Neighboring gene FERM and PDZ domain containing 4 Neighboring gene histone transcription regulator 3 homolog Neighboring gene phosphoribosyl pyrophosphate synthetase 2 Neighboring gene uncharacterized LOC100511794 Neighboring gene toll like receptor 7 Neighboring gene thymosin beta 4 X-linked

    Genomic regions, transcripts, and products

    Bibliography

    Related articles in PubMed

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    General protein information

    Preferred Names
    toll-like receptor 8
    Names
    Toll-like receptor 7

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_214187.1NP_999352.1  toll-like receptor 8 precursor

      See identical proteins and their annotated locations for NP_999352.1

      Status: PROVISIONAL

      Source sequence(s)
      AB092975
      UniProtKB/TrEMBL
      Q865R7
      Related
      ENSSSCP00000030352.1, ENSSSCT00000033339.2
      Conserved Domains (6) summary
      smart00082
      Location:761806
      LRRCT; Leucine rich repeat C-terminal domain
      smart00255
      Location:8691005
      TIR; Toll - interleukin 1 - resistance
      cd00116
      Location:569762
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:500521
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:213246
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:212289
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010461.5 Reference Sscrofa11.1 Primary Assembly

      Range
      9551284..9616762
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021079509.1XP_020935168.1  toll-like receptor 8 isoform X3

      Conserved Domains (6) summary
      smart00082
      Location:761806
      LRRCT; Leucine rich repeat C-terminal domain
      smart00255
      Location:8691005
      TIR; Toll - interleukin 1 - resistance
      sd00033
      Location:500521
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:6294
      LRR_8; Leucine rich repeat
      cl26018
      Location:630765
      NEL; C-terminal novel E3 ligase, LRR-interacting
      cl26793
      Location:154690
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    2. XM_021079507.1XP_020935166.1  toll-like receptor 8 isoform X3

      Conserved Domains (6) summary
      smart00082
      Location:761806
      LRRCT; Leucine rich repeat C-terminal domain
      smart00255
      Location:8691005
      TIR; Toll - interleukin 1 - resistance
      sd00033
      Location:500521
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:6294
      LRR_8; Leucine rich repeat
      cl26018
      Location:630765
      NEL; C-terminal novel E3 ligase, LRR-interacting
      cl26793
      Location:154690
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    3. XM_021079508.1XP_020935167.1  toll-like receptor 8 isoform X3

      Conserved Domains (6) summary
      smart00082
      Location:761806
      LRRCT; Leucine rich repeat C-terminal domain
      smart00255
      Location:8691005
      TIR; Toll - interleukin 1 - resistance
      sd00033
      Location:500521
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:6294
      LRR_8; Leucine rich repeat
      cl26018
      Location:630765
      NEL; C-terminal novel E3 ligase, LRR-interacting
      cl26793
      Location:154690
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    4. XM_021079505.1XP_020935164.1  toll-like receptor 8 isoform X1

      Conserved Domains (6) summary
      TIGR00864
      Location:810893
      PCC; polycystin cation channel protein
      smart00255
      Location:9481084
      TIR; Toll - interleukin 1 - resistance
      sd00033
      Location:579600
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:141173
      LRR_8; Leucine rich repeat
      cl26018
      Location:709844
      NEL; C-terminal novel E3 ligase, LRR-interacting
      cl26793
      Location:233769
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    5. XM_021079506.1XP_020935165.1  toll-like receptor 8 isoform X2

      Related
      ENSSSCP00000012899.3, ENSSSCT00000013255.3
      Conserved Domains (5) summary
      smart00082
      Location:839884
      LRRCT; Leucine rich repeat C-terminal domain
      smart00255
      Location:9471083
      TIR; Toll - interleukin 1 - resistance
      sd00033
      Location:578599
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:755815
      LRR_8; Leucine rich repeat
      cl26793
      Location:232768
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    6. XM_013985895.2XP_013841349.1  toll-like receptor 8 isoform X3

      UniProtKB/TrEMBL
      B3XXC2
      Conserved Domains (6) summary
      smart00082
      Location:761806
      LRRCT; Leucine rich repeat C-terminal domain
      smart00255
      Location:8691005
      TIR; Toll - interleukin 1 - resistance
      sd00033
      Location:500521
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:6294
      LRR_8; Leucine rich repeat
      cl26018
      Location:630765
      NEL; C-terminal novel E3 ligase, LRR-interacting
      cl26793
      Location:154690
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    7. XM_013985896.2XP_013841350.1  toll-like receptor 8 isoform X3

      UniProtKB/TrEMBL
      B3XXC2
      Conserved Domains (6) summary
      smart00082
      Location:761806
      LRRCT; Leucine rich repeat C-terminal domain
      smart00255
      Location:8691005
      TIR; Toll - interleukin 1 - resistance
      sd00033
      Location:500521
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:6294
      LRR_8; Leucine rich repeat
      cl26018
      Location:630765
      NEL; C-terminal novel E3 ligase, LRR-interacting
      cl26793
      Location:154690
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    8. XM_013985894.2XP_013841348.1  toll-like receptor 8 isoform X3

      UniProtKB/TrEMBL
      B3XXC2
      Conserved Domains (6) summary
      smart00082
      Location:761806
      LRRCT; Leucine rich repeat C-terminal domain
      smart00255
      Location:8691005
      TIR; Toll - interleukin 1 - resistance
      sd00033
      Location:500521
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:6294
      LRR_8; Leucine rich repeat
      cl26018
      Location:630765
      NEL; C-terminal novel E3 ligase, LRR-interacting
      cl26793
      Location:154690
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    9. XM_005673404.3XP_005673461.1  toll-like receptor 8 isoform X3

      See identical proteins and their annotated locations for XP_005673461.1

      UniProtKB/TrEMBL
      B3XXC2
      Related
      ENSSSCP00000031310.1, ENSSSCT00000064062.1
      Conserved Domains (6) summary
      smart00082
      Location:761806
      LRRCT; Leucine rich repeat C-terminal domain
      smart00255
      Location:8691005
      TIR; Toll - interleukin 1 - resistance
      sd00033
      Location:500521
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:6294
      LRR_8; Leucine rich repeat
      cl26018
      Location:630765
      NEL; C-terminal novel E3 ligase, LRR-interacting
      cl26793
      Location:154690
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    10. XM_005673405.3XP_005673462.1  toll-like receptor 8 isoform X3

      See identical proteins and their annotated locations for XP_005673462.1

      UniProtKB/TrEMBL
      B3XXC2
      Related
      ENSSSCP00000030972.1, ENSSSCT00000033711.2
      Conserved Domains (6) summary
      smart00082
      Location:761806
      LRRCT; Leucine rich repeat C-terminal domain
      smart00255
      Location:8691005
      TIR; Toll - interleukin 1 - resistance
      sd00033
      Location:500521
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:6294
      LRR_8; Leucine rich repeat
      cl26018
      Location:630765
      NEL; C-terminal novel E3 ligase, LRR-interacting
      cl26793
      Location:154690
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
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