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    ADAM10 ADAM metallopeptidase domain 10 [ Sus scrofa (pig) ]

    Gene ID: 397345, updated on 11-Jun-2019

    Summary

    Gene symbol
    ADAM10
    Gene description
    ADAM metallopeptidase domain 10
    See related
    Ensembl:ENSSSCG00000004595
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae; Sus
    Also known as
    ADAM-10
    Expression
    Ubiquitous expression in lung (RPKM 55.5), spleen (RPKM 28.4) and 8 other tissues See more
    Orthologs

    Genomic context

    See ADAM10 in Genome Data Viewer
    Location:
    1; 1
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 1 NC_010443.5 (113289480..113407940)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) 1 NC_010443.4 (125476146..125527319, complement)

    Chromosome 1 - NC_010443.5Genomic Context describing neighboring genes Neighboring gene 28S ribosomal protein S17, mitochondrial-like Neighboring gene MINDY lysine 48 deubiquitinase 2 Neighboring gene 40S ribosomal protein S15a pseudogene Neighboring gene 40S ribosomal protein S23 pseudogene Neighboring gene uncharacterized LOC102158936 Neighboring gene lipase C, hepatic type Neighboring gene aquaporin 9

    Genomic regions, transcripts, and products

    Pathways from BioSystems

    • Alzheimer's disease, organism-specific biosystem (from KEGG)
      Alzheimer's disease, organism-specific biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
    • Alzheimer's disease, conserved biosystem (from KEGG)
      Alzheimer's disease, conserved biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    endopeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    metalloendopeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    metalloendopeptidase activity involved in amyloid precursor protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    PMA-inducible membrane protein ectodomain proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    amyloid precursor protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    cochlea development IEA
    Inferred from Electronic Annotation
    more info
     
    constitutive protein ectodomain proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    in utero embryonic development IEA
    Inferred from Electronic Annotation
    more info
     
    membrane protein ectodomain proteolysis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    monocyte activation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    pore complex assembly IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of T cell chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell growth IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    postsynapse organization IEA
    Inferred from Electronic Annotation
    more info
     
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    protein processing IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of neurotransmitter receptor localization to postsynaptic specialization membrane IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of vasculature development IEA
    Inferred from Electronic Annotation
    more info
     
    response to tumor necrosis factor IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Golgi-associated vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    adherens junction IEA
    Inferred from Electronic Annotation
    more info
     
    cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    perinuclear endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    pore complex IEA
    Inferred from Electronic Annotation
    more info
     
    postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
     
    synaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    tetraspanin-enriched microdomain IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    disintegrin and metalloproteinase domain-containing protein 10
    Names
    ADAM 10
    a disintegrin and metalloproteinase domain-containing protein 10
    disintegrin-metalloproteinase
    kuzbanian protein homolog
    mammalian disintegrin-metalloprotease
    NP_001124003.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130531.1NP_001124003.1  disintegrin and metalloproteinase domain-containing protein 10 precursor

      See identical proteins and their annotated locations for NP_001124003.1

      Status: PROVISIONAL

      Source sequence(s)
      EU753851
      UniProtKB/TrEMBL
      B3VKE8
      Related
      ENSSSCP00000028395.2, ENSSSCT00000032619.2
      Conserved Domains (3) summary
      smart00050
      Location:466545
      DISIN; Homologues of snake disintegrins
      cd04270
      Location:220459
      ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.
      pfam01562
      Location:48141
      Pep_M12B_propep; Reprolysin family propeptide

    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010443.5 Reference Sscrofa11.1 Primary Assembly

      Range
      113289480..113407940
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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