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    F8 coagulation factor VIII [ Sus scrofa (pig) ]

    Gene ID: 397339, updated on 2-Oct-2018

    Summary

    Gene symbol
    F8
    Gene description
    coagulation factor VIII
    See related
    Ensembl:ENSSSCG00000012818 Vega:OTTSUSG00000004959
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae; Sus
    Expression
    Ubiquitous expression in lung (RPKM 8.9), spleen (RPKM 8.7) and 8 other tissues See more
    Orthologs

    Genomic context

    Location:
    chromosome: X
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) X NC_010461.5 (125265330..125350853, complement)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) X NC_010461.4 (143132160..143217828)

    Chromosome X - NC_010461.5Genomic Context describing neighboring genes Neighboring gene membrane palmitoylated protein 1 Neighboring gene small integral membrane protein 9 Neighboring gene histone H2A-Bbd type 2/3 Neighboring gene coagulation factor VIII-associated 1 Neighboring gene FUN14 domain containing 2 Neighboring gene mature T cell proliferation 1 Neighboring gene C-X9-C motif containing 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Bibliography

    Related articles in PubMed

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    General gene information

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    copper ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acute-phase response IEA
    Inferred from Electronic Annotation
    more info
     
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    platelet activation IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    coagulation factor VIII
    Names
    coagulation factor VIII, procoagulant component (hemophilia A)
    factor VIII
    procoagulant component

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_214167.2NP_999332.2  coagulation factor VIII precursor

      Status: VALIDATED

      Source sequence(s)
      CU914693
      Related
      ENSSSCP00000028556.2, OTTSUSP00000008790, ENSSSCT00000035558.2, OTTSUST00000012472
      Conserved Domains (2) summary
      cd00057
      Location:19782127
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cl19115
      Location:399575
      Cupredoxin; Cupredoxin superfamily

    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010461.5 Reference Sscrofa11.1 Primary Assembly

      Range
      125265330..125350853 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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