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    LCK LCK proto-oncogene, Src family tyrosine kinase [ Gallus gallus (chicken) ]

    Gene ID: 396460, updated on 12-Aug-2018

    Summary

    Symbol
    LCKprovided by CGNC
    Full Name
    LCK proto-oncogene, Src family tyrosine kinaseprovided by CGNC
    Primary source
    CGNC:49815
    See related
    Ensembl:ENSGALG00000000466
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    tkl; P56LCK
    Orthologs

    Genomic context

    See LCK in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    104 current GRCg6a (GCF_000002315.5) 23 NC_006110.5 (5286476..5293228, complement)
    103 previous assembly Gallus_gallus-5.0 (GCF_000002315.4) 23 NC_006110.4 (5152970..5159766, complement)

    Chromosome 23 - NC_006110.5Genomic Context describing neighboring genes Neighboring gene MARCKS like 1 Neighboring gene histone deacetylase 1 Neighboring gene family with sequence similarity 167, member B Neighboring gene myotubularin related protein 9-like, pseudogene

    Genomic regions, transcripts, and products

    General gene information

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    SH2 domain binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    non-membrane spanning protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein serine/threonine phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein tyrosine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    B cell receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    T cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    T cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    activation of cysteine-type endopeptidase activity involved in apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cellular zinc ion homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    peptidyl-tyrosine autophosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of T cell activation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of intrinsic apoptotic signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    response to drug ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    transmembrane receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    extrinsic component of cytoplasmic side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    membrane raft ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    pericentriolar material ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    proto-oncogene tyrosine-protein kinase LCK
    Names
    lymphocyte-specific protein tyrosine kinase
    tyrosine protein kinase
    tyrosine-protein kinase LCK

    NCBI Reference Sequences (RefSeq)

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 104 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCg6a Primary Assembly

    Genomic

    1. NC_006110.5 Reference GRCg6a Primary Assembly

      Range
      5286476..5293228 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015297855.2XP_015153341.1  proto-oncogene tyrosine-protein kinase LCK isoform X2

      Conserved Domains (3) summary
      cd10362
      Location:121221
      SH2_Src_Lck; Src homology 2 (SH2) domain in lymphocyte cell kinase (Lck)
      cd12005
      Location:63116
      SH3_Lck; Src homology 3 domain of Lck Protein Tyrosine Kinase
      cd05067
      Location:235498
      PTKc_Lck_Blk; Catalytic domain of the Protein Tyrosine Kinases, Lymphocyte-specific kinase and Blk
    2. XM_015297854.2XP_015153340.1  proto-oncogene tyrosine-protein kinase LCK isoform X1

      UniProtKB/TrEMBL
      F1NP54
      Related
      ENSGALP00000000634.4
      Conserved Domains (4) summary
      cd10362
      Location:122222
      SH2_Src_Lck; Src homology 2 (SH2) domain in lymphocyte cell kinase (Lck)
      cd12005
      Location:64117
      SH3_Lck; Src homology 3 domain of Lck Protein Tyrosine Kinase
      cd05067
      Location:236499
      PTKc_Lck_Blk; Catalytic domain of the Protein Tyrosine Kinases, Lymphocyte-specific kinase and Blk
      pfam07714
      Location:244493
      Pkinase_Tyr; Protein tyrosine kinase
    3. XM_025143066.1XP_024998834.1  proto-oncogene tyrosine-protein kinase LCK isoform X2

      Conserved Domains (3) summary
      cd10362
      Location:121221
      SH2_Src_Lck; Src homology 2 (SH2) domain in lymphocyte cell kinase (Lck)
      cd12005
      Location:63116
      SH3_Lck; Src homology 3 domain of Lck Protein Tyrosine Kinase
      cd05067
      Location:235498
      PTKc_Lck_Blk; Catalytic domain of the Protein Tyrosine Kinases, Lymphocyte-specific kinase and Blk
    4. XM_427615.6XP_427615.3  proto-oncogene tyrosine-protein kinase LCK isoform X1

      UniProtKB/TrEMBL
      F1NP54
      Conserved Domains (4) summary
      cd10362
      Location:122222
      SH2_Src_Lck; Src homology 2 (SH2) domain in lymphocyte cell kinase (Lck)
      cd12005
      Location:64117
      SH3_Lck; Src homology 3 domain of Lck Protein Tyrosine Kinase
      cd05067
      Location:236499
      PTKc_Lck_Blk; Catalytic domain of the Protein Tyrosine Kinases, Lymphocyte-specific kinase and Blk
      pfam07714
      Location:244493
      Pkinase_Tyr; Protein tyrosine kinase
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