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    GATA4 GATA binding protein 4 [ Gallus gallus (chicken) ]

    Gene ID: 396392, updated on 25-Sep-2018

    Summary

    Symbol
    GATA4provided by CGNC
    Full Name
    GATA binding protein 4provided by CGNC
    Primary source
    CGNC:12483
    See related
    Ensembl:ENSGALG00000016662
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    GATA-4
    Orthologs

    Genomic context

    See GATA4 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    104 current GRCg6a (GCF_000002315.5) 3 NC_006090.5 (107326402..107354099)
    103 previous assembly Gallus_gallus-5.0 (GCF_000002315.4) 3 NC_006090.4 (107785477..107811680)

    Chromosome 3 - NC_006090.5Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112532133 Neighboring gene family with sequence similarity 167, member A Neighboring gene BLK proto-oncogene, Src family tyrosine kinase Neighboring gene uncharacterized LOC100858393 Neighboring gene nei like DNA glycosylase 2 Neighboring gene farnesyl-diphosphate farnesyltransferase 1

    Genomic regions, transcripts, and products

    Pathways from BioSystems

    • Tight junction, organism-specific biosystem (from KEGG)
      Tight junction, organism-specific biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...
    • Tight junction, conserved biosystem (from KEGG)
      Tight junction, conserved biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...

    General gene information

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    RNA polymerase II proximal promoter sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    anatomical structure formation involved in morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    animal organ morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    heart development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription, DNA-templated ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    response to retinoic acid TAS
    Traceable Author Statement
    more info
    PubMed 
    tissue development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    transcription factor GATA-4
    Names
    GATA-binding factor 4

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001293106.1NP_001280035.1  transcription factor GATA-4

      Status: VALIDATED

      Source sequence(s)
      AADN05001052, U11887
      UniProtKB/Swiss-Prot
      P43691
      UniProtKB/TrEMBL
      E1C9C6
      Related
      ENSGALP00000030912.3, ENSGALT00000031548.3
      Conserved Domains (3) summary
      smart00401
      Location:238285
      ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
      cd00202
      Location:240291
      ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
      pfam05349
      Location:1175
      GATA-N; GATA-type transcription activator, N-terminal

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 104 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCg6a Primary Assembly

    Genomic

    1. NC_006090.5 Reference GRCg6a Primary Assembly

      Range
      107326402..107354099
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_025148584.1XP_025004352.1  transcription factor GATA-4 isoform X2

      Conserved Domains (2) summary
      cd00202
      Location:98149
      ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
      pfam05349
      Location:132
      GATA-N; GATA-type transcription activator, N-terminal
    2. XM_004935896.3XP_004935953.1  transcription factor GATA-4 isoform X1

      Conserved Domains (3) summary
      smart00401
      Location:239286
      ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
      cd00202
      Location:241292
      ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
      pfam05349
      Location:1175
      GATA-N; GATA-type transcription activator, N-terminal
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