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    FGA fibrinogen alpha chain [ Gallus gallus (chicken) ]

    Gene ID: 396307, updated on 14-Feb-2019

    Summary

    Official Symbol
    FGAprovided by CGNC
    Official Full Name
    fibrinogen alpha chainprovided by CGNC
    Primary source
    CGNC:49746
    See related
    Ensembl:ENSGALG00000009266
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs

    Genomic context

    See FGA in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    104 current GRCg6a (GCF_000002315.5) 4 NC_006091.5 (20321300..20328191, complement)
    103 previous assembly Gallus_gallus-5.0 (GCF_000002315.4) 4 NC_006091.4 (20484771..20491662, complement)
    102 previous assembly Gallus_gallus-4.0 (GCF_000002315.3) 4 NC_006091.3 (19793620..19800511, complement)

    Chromosome 4 - NC_006091.5Genomic Context describing neighboring genes Neighboring gene pleiotropic regulator 1 Neighboring gene fibrinogen beta chain Neighboring gene uncharacterized LOC100857197 Neighboring gene fibrinogen gamma chain

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Blood Clotting Cascade, organism-specific biosystem (from WikiPathways)
      Blood Clotting Cascade, organism-specific biosystemCoagulation is a complex process by which blood forms clots. It is an important part of hemostasis (the cessation of blood loss from a damaged vessel), wherein a damaged blood vessel wall is covered ...

    General gene information

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding, bridging IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    signaling receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    platelet activation IEA
    Inferred from Electronic Annotation
    more info
     
    protein polymerization IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    fibrinogen complex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 

    General protein information

    Preferred Names
    fibrinogen alpha chain
    Names
    fibrinogen alpha subunit
    fibrinogen alpha-E subunit
    pre-fibrinogen alpha subunit

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271911.1NP_001258840.1  fibrinogen alpha chain isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1).
      Source sequence(s)
      AADN05000019, BG641954, BU124839, BU125048, BU251255
      Related
      ENSGALP00000015061.5, ENSGALT00000015077.6
      Conserved Domains (4) summary
      cd00087
      Location:503738
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
      pfam08192
      Location:375484
      Peptidase_S64; Peptidase family S64
      pfam08702
      Location:50191
      Fib_alpha; Fibrinogen alpha/beta chain family
      pfam12160
      Location:299364
      Fibrinogen_aC; Fibrinogen alpha C domain
    2. NM_205356.2NP_990687.2  fibrinogen alpha chain isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR, and uses an alternate exon structure in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to variant 1.
      Source sequence(s)
      AADN05000019, BG641954, BU125048, M34096
      Conserved Domains (3) summary
      pfam08192
      Location:375484
      Peptidase_S64; Peptidase family S64
      pfam08702
      Location:50191
      Fib_alpha; Fibrinogen alpha/beta chain family
      pfam12160
      Location:299364
      Fibrinogen_aC; Fibrinogen alpha C domain

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 104 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCg6a Primary Assembly

    Genomic

    1. NC_006091.5 Reference GRCg6a Primary Assembly

      Range
      20321300..20328191 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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