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    KITLG KIT ligand [ Gallus gallus (chicken) ]

    Gene ID: 396028, updated on 2-Oct-2018

    Summary

    Symbol
    KITLGprovided by CGNC
    Full Name
    KIT ligandprovided by CGNC
    Primary source
    CGNC:8510
    See related
    Ensembl:ENSGALG00000011206
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs

    Genomic context

    See KITLG in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    104 current GRCg6a (GCF_000002315.5) 1 NC_006088.5 (43015486..43066975, complement)
    103 previous assembly Gallus_gallus-5.0 (GCF_000002315.4) 1 NC_006088.4 (42981399..43032887, complement)

    Chromosome 1 - NC_006088.5Genomic Context describing neighboring genes Neighboring gene chromosome 1 C12orf29 homolog Neighboring gene centrosomal protein 290 Neighboring gene transmembrane and tetratricopeptide repeat containing 3 Neighboring gene uncharacterized LOC107052880 Neighboring gene uncharacterized LOC112533343 Neighboring gene dual specificity phosphatase 6

    Genomic regions, transcripts, and products

    Bibliography

    Pathways from BioSystems

    • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Kit Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Kit Receptor Signaling Pathway, organism-specific biosystemKit is a receptor protein tyrosine kinase, which is a receptor for stem cell factor or kit ligand. Signaling through Kit is important for formation of red cells, lymphocytes, mast cells and platelets...
    • Melanogenesis, organism-specific biosystem (from KEGG)
      Melanogenesis, organism-specific biosystemCutaneous melanin pigment plays a critical role in camouflage, mimicry, social communication, and protection against harmful effects of solar radiation. Melanogenesis is under complex regulatory cont...
    • Melanogenesis, conserved biosystem (from KEGG)
      Melanogenesis, conserved biosystemCutaneous melanin pigment plays a critical role in camouflage, mimicry, social communication, and protection against harmful effects of solar radiation. Melanogenesis is under complex regulatory cont...

    General gene information

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    cytokine activity IEA
    Inferred from Electronic Annotation
    more info
     
    growth factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    stem cell factor receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    ectopic germ cell programmed cell death IEA
    Inferred from Electronic Annotation
    more info
     
    embryonic hemopoiesis IEA
    Inferred from Electronic Annotation
    more info
     
    extrinsic apoptotic signaling pathway in absence of ligand IEA
    Inferred from Electronic Annotation
    more info
     
    male gonad development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of mast cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    neural crest cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of MAP kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of Ras protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of hematopoietic stem cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of leukocyte migration IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of mast cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of melanocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of myeloid leukocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of peptidyl-tyrosine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    filopodium ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    lamellipodium ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    kit ligand
    Names
    C-kit ligand
    KIT ligand precursor form 1
    KIT ligand precursor form 4
    MGF
    SCF
    mast cell growth factor
    stem cell factor
    NP_001098785.1
    NP_990461.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105315.1NP_001098785.1  kit ligand isoform 2 precursor

      See identical proteins and their annotated locations for NP_001098785.1

      Status: PROVISIONAL

      Source sequence(s)
      DQ870922
      UniProtKB/TrEMBL
      Q009U4
      Related
      ENSGALP00000042694.2, ENSGALT00000044248.2
      Conserved Domains (1) summary
      pfam02404
      Location:1227
      SCF; Stem cell factor
    2. NM_205130.1NP_990461.1  kit ligand isoform 1 precursor

      See identical proteins and their annotated locations for NP_990461.1

      Status: PROVISIONAL

      Source sequence(s)
      D13516
      UniProtKB/Swiss-Prot
      Q09108
      UniProtKB/TrEMBL
      Q009U6
      Related
      ENSGALP00000018246.3, ENSGALT00000018268.3
      Conserved Domains (1) summary
      pfam02404
      Location:1287
      SCF; Stem cell factor

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 104 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCg6a Primary Assembly

    Genomic

    1. NC_006088.5 Reference GRCg6a Primary Assembly

      Range
      43015486..43066975 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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