Format

Send to:

Choose Destination
    • Showing Current items.

    VEGFA vascular endothelial growth factor A [ Gallus gallus (chicken) ]

    Gene ID: 395909, updated on 2-Jul-2019

    Summary

    Symbol
    VEGFAprovided by CGNC
    Full Name
    vascular endothelial growth factor Aprovided by CGNC
    Primary source
    CGNC:7830
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    VEGF
    Orthologs

    Genomic context

    See VEGFA in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    104 current GRCg6a (GCF_000002315.5) 3 NC_006090.5 (30775995..30795873, complement)
    103 previous assembly Gallus_gallus-5.0 (GCF_000002315.4) 3 NC_006090.4 (30739147..30759022, complement)
    102 previous assembly Gallus_gallus-4.0 (GCF_000002315.3) 3 NC_006090.3 (30013851..30033731, complement)

    Chromosome 3 - NC_006090.5Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107052902 Neighboring gene uncharacterized LOC107052903 Neighboring gene uncharacterized LOC107052901 Neighboring gene uncharacterized LOC112532063 Neighboring gene uncharacterized LOC107052900 Neighboring gene uncharacterized LOC101750447

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • AGE-RAGE signaling pathway in diabetic complications, organism-specific biosystem (from KEGG)
      AGE-RAGE signaling pathway in diabetic complications, organism-specific biosystemAdvanced glycation end products (AGEs) are a complex group of compounds produced through the non-enzymatic glycation and oxidation of proteins, lipids and nucleic acids, primarily due to aging and un...
    • AGE-RAGE signaling pathway in diabetic complications, conserved biosystem (from KEGG)
      AGE-RAGE signaling pathway in diabetic complications, conserved biosystemAdvanced glycation end products (AGEs) are a complex group of compounds produced through the non-enzymatic glycation and oxidation of proteins, lipids and nucleic acids, primarily due to aging and un...
    • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Focal adhesion, organism-specific biosystem (from KEGG)
      Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, conserved biosystem (from KEGG)
      Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Id Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Id Signaling Pathway, organism-specific biosystemInhibitor of DNA binding (ID) proteins are members of the helix-loop-helix (HLH) family of proteins which lack a DNA binding domain themselves but bind to other family members inhibiting their DNA bi...
    • VEGF signaling pathway, organism-specific biosystem (from KEGG)
      VEGF signaling pathway, organism-specific biosystemThere is now much evidence that VEGFR-2 is the major mediator of VEGF-driven responses in endothelial cells and it is considered to be a crucial signal transducer in both physiologic and pathologic a...
    • VEGF signaling pathway, conserved biosystem (from KEGG)
      VEGF signaling pathway, conserved biosystemThere is now much evidence that VEGFR-2 is the major mediator of VEGF-driven responses in endothelial cells and it is considered to be a crucial signal transducer in both physiologic and pathologic a...

    General gene information

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    chemoattractant activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    growth factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    heparin binding IEA
    Inferred from Electronic Annotation
    more info
     
    vascular endothelial growth factor receptor 1 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    vascular endothelial growth factor receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    blood vessel maturation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    epicardial cell to mesenchymal cell transition TAS
    Traceable Author Statement
    more info
    PubMed 
    induction of positive chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of cell division IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of endothelial cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of endothelial cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of focal adhesion assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of mast cell chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of peptidyl-tyrosine phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of protein complex assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of vascular permeability ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    response to hypoxia IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    sprouting angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    vascular endothelial growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    vascular endothelial growth factor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    vascular endothelial growth factor A
    Names
    VEGF-A
    VPF
    vascular permeability factor

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110355.1NP_001103825.1  vascular endothelial growth factor A isoform 2 precursor

      See identical proteins and their annotated locations for NP_001103825.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) is lacking an in-frame, coding exon compared to transcript variant 1, resulting in a shorter isoform (2) that is missing a 24 aa segment, compared to isoform 1.
      Source sequence(s)
      AADN05000005, AB011078, AM071319, AY168004
      UniProtKB/Swiss-Prot
      P67964
      UniProtKB/TrEMBL
      Q540I2
      Conserved Domains (2) summary
      smart00141
      Location:50132
      PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
      pfam14554
      Location:144192
      VEGF_C; VEGF heparin-binding domain
    2. NM_205042.2NP_990373.1  vascular endothelial growth factor A isoform 1 precursor

      See identical proteins and their annotated locations for NP_990373.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AADN05000005, AB011078, AM071319
      UniProtKB/Swiss-Prot
      P67964
      UniProtKB/TrEMBL
      F1NAQ1
      Conserved Domains (2) summary
      smart00141
      Location:50132
      PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
      pfam14554
      Location:168216
      VEGF_C; VEGF heparin-binding domain

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 104 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCg6a Primary Assembly

    Genomic

    1. NC_006090.5 Reference GRCg6a Primary Assembly

      Range
      30775995..30795873 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center