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    OAZ1 ornithine decarboxylase antizyme 1 [ Gallus gallus (chicken) ]

    Gene ID: 395746, updated on 2-Oct-2018

    Summary

    Symbol
    OAZ1provided by CGNC
    Full Name
    ornithine decarboxylase antizyme 1provided by CGNC
    Primary source
    CGNC:524
    See related
    Ensembl:ENSGALG00000000812
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    OAZ
    Summary
    The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamine in cells. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis pathway; thus, completing the auto-regulatory circuit. This gene encodes antizyme 1, the first member of the antizyme family, that has broad tissue distribution, and negatively regulates intracellular polyamine levels by binding to and targeting ODC for degradation, as well as by inhibiting polyamine uptake. Antizyme 1 mRNA contains two potential in-frame AUGs, and studies in rat suggest that alternative use of the two translation initiation sites results in N-terminally distinct protein isoforms with different subcellular localization (PMID:16120325). [provided by RefSeq, Jul 2014]
    Orthologs

    Genomic context

    See OAZ1 in Genome Data Viewer
    Location:
    chromosome: 28
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    104 current GRCg6a (GCF_000002315.5) 28 NC_006115.5 (2082137..2086055, complement)
    103 previous assembly Gallus_gallus-5.0 (GCF_000002315.4) 28 NC_006115.4 (1993415..1997335, complement)

    Chromosome 28 - NC_006115.5Genomic Context describing neighboring genes Neighboring gene leucine rich repeat and Ig domain containing 3 Neighboring gene PEAK family member 3 Neighboring gene anti-Mullerian hormone Neighboring gene splicing factor 3a subunit 2

    Genomic regions, transcripts, and products

    General gene information

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ornithine decarboxylase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    negative regulation of catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    polyamine metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    ornithine decarboxylase antizyme 1
    Names
    ODC-Az
    antizyme 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_204916.1NP_990247.1  ornithine decarboxylase antizyme 1

      See identical proteins and their annotated locations for NP_990247.1

      Status: REVIEWED

      Source sequence(s)
      AF007806
      UniProtKB/Swiss-Prot
      O42148
      Related
      ENSGALP00000040427.3, ENSGALT00000041222.3
      Conserved Domains (1) summary
      pfam02100
      Location:126207
      ODC_AZ; Ornithine decarboxylase antizyme

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 104 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCg6a Primary Assembly

    Genomic

    1. NC_006115.5 Reference GRCg6a Primary Assembly

      Range
      2082137..2086055 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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