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    HMGB1 high mobility group box 1 [ Gallus gallus (chicken) ]

    Gene ID: 395724, updated on 27-Dec-2019

    Summary

    Official Symbol
    HMGB1provided by CGNC
    Official Full Name
    high mobility group box 1provided by CGNC
    Primary source
    CGNC:49444
    See related
    Ensembl:ENSGALG00000042875
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    HMG1; HMG-1
    Orthologs

    Genomic context

    See HMGB1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    104 current GRCg6a (GCF_000002315.5) 1 NC_006088.5 (176491447..176499617)
    103 previous assembly Gallus_gallus-5.0 (GCF_000002315.4) 1 NC_006088.4 (175163150..175171321)
    102 previous assembly Gallus_gallus-4.0 (GCF_000002315.3) 1 NC_006088.3 (174411695..174418074)

    Chromosome 1 - NC_006088.5Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase like 1 Neighboring gene uncharacterized LOC101747923 Neighboring gene translation initiation factor IF-2-like Neighboring gene uncharacterized LOC107052100 Neighboring gene microRNA 1646 Neighboring gene katanin catalytic subunit A1 like 1

    Genomic regions, transcripts, and products

    Pathways from PubChem

    General gene information

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    C-X-C chemokine binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA binding, bending IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    DNA binding, bending IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA polymerase binding IEA
    Inferred from Electronic Annotation
    more info
     
    bubble DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    calcium-dependent protein kinase regulator activity IEA
    Inferred from Electronic Annotation
    more info
     
    cytokine activity IEA
    Inferred from Electronic Annotation
    more info
     
    damaged DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    double-stranded RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    four-way junction DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integrin binding IEA
    Inferred from Electronic Annotation
    more info
     
    lipopolysaccharide binding IEA
    Inferred from Electronic Annotation
    more info
     
    lyase activity IEA
    Inferred from Electronic Annotation
    more info
     
    non-sequence-specific DNA binding, bending ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    phosphatidylserine binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    repressing transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    single-stranded RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    supercoiled DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription coactivator activity IEA
    Inferred from Electronic Annotation
    more info
     
    transcription factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transcription regulatory region DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    DNA geometric change IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA ligation involved in DNA repair ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    DNA recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    T-helper 1 cell activation IEA
    Inferred from Electronic Annotation
    more info
     
    T-helper 1 cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    V(D)J recombination IEA
    Inferred from Electronic Annotation
    more info
     
    activation of innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    activation of protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    apoptotic cell clearance IEA
    Inferred from Electronic Annotation
    more info
     
    base-excision repair IEA
    Inferred from Electronic Annotation
    more info
     
    cell chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cellular response to interleukin-7 IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
     
    chromatin assembly IEA
    Inferred from Electronic Annotation
    more info
     
    chromatin silencing IEA
    Inferred from Electronic Annotation
    more info
     
    developmental process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    endothelial cell chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    endothelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    eye development IEA
    Inferred from Electronic Annotation
    more info
     
    inflammatory response to antigenic stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    lung development IEA
    Inferred from Electronic Annotation
    more info
     
    macrophage activation involved in immune response IEA
    Inferred from Electronic Annotation
    more info
     
    myeloid dendritic cell activation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of CD4-positive, alpha-beta T cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of RNA polymerase II transcriptional preinitiation complex assembly IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of apoptotic cell clearance IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of blood vessel endothelial cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of interferon-gamma production IEA
    Inferred from Electronic Annotation
    more info
     
    neutrophil clearance IEA
    Inferred from Electronic Annotation
    more info
     
    plasmacytoid dendritic cell activation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of ERK1 and ERK2 cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of JNK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of NIK/NF-kappaB signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of activated T cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of autophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of blood vessel endothelial cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cytosolic calcium ion concentration IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of dendritic cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of glycogen catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of interferon-alpha secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of interferon-beta production IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of interleukin-1 beta secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of interleukin-1 secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of interleukin-10 production IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of interleukin-12 production IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of interleukin-6 production IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of interleukin-6 secretion IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of mismatch repair IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of monocyte chemotactic protein-1 production IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of monocyte chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of myeloid cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of sprouting angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of toll-like receptor 2 signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of toll-like receptor 4 signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of tumor necrosis factor production IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of vascular endothelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of wound healing IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of T cell mediated immune response to tumor cell IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of nucleotide-excision repair IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of restriction endodeoxyribonuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of tolerance induction IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    response to glucocorticoid IEA
    Inferred from Electronic Annotation
    more info
     
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    tumor necrosis factor secretion IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    alphav-beta3 integrin-HMGB1 complex IEA
    Inferred from Electronic Annotation
    more info
     
    cell ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    condensed chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    early endosome IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    neuron projection IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transcriptional repressor complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    high mobility group protein B1
    Names
    high mobility group 1 protein
    high mobility group protein 1
    high mobility group protein HMG1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_204902.2NP_990233.1  high mobility group protein B1

      See identical proteins and their annotated locations for NP_990233.1

      Status: PROVISIONAL

      Source sequence(s)
      AJ851648
      UniProtKB/Swiss-Prot
      Q9YH06
      Related
      ENSGALP00000044781.1, ENSGALT00000075072.2
      Conserved Domains (2) summary
      pfam00505
      Location:95162
      HMG_box; HMG (high mobility group) box
      pfam09011
      Location:778
      HMG_box_2; HMG-box domain

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 104 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCg6a Primary Assembly

    Genomic

    1. NC_006088.5 Reference GRCg6a Primary Assembly

      Range
      176491447..176499617
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015277670.1XP_015133156.1  high mobility group protein B1 isoform X1

      UniProtKB/Swiss-Prot
      Q9YH06
      Conserved Domains (2) summary
      pfam00505
      Location:95162
      HMG_box; HMG (high mobility group) box
      pfam09011
      Location:778
      HMG_box_2; HMG-box domain
    2. XM_015277667.2XP_015133153.1  high mobility group protein B1 isoform X1

      UniProtKB/Swiss-Prot
      Q9YH06
      Conserved Domains (2) summary
      pfam00505
      Location:95162
      HMG_box; HMG (high mobility group) box
      pfam09011
      Location:778
      HMG_box_2; HMG-box domain
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