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    KRT18 keratin 18 [ Homo sapiens (human) ]

    Gene ID: 3875, updated on 5-Dec-2021

    Summary

    Official Symbol
    KRT18provided by HGNC
    Official Full Name
    keratin 18provided by HGNC
    Primary source
    HGNC:HGNC:6430
    See related
    Ensembl:ENSG00000111057 MIM:148070
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    K18; CK-18; CYK18
    Summary
    KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in placenta (RPKM 258.0), colon (RPKM 230.1) and 15 other tissues See more
    Orthologs
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    Genomic context

    See KRT18 in Genome Data Viewer
    Location:
    12q13.13
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109.20211119 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (52948855..52952906)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (53342639..53346690)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein L7 pseudogene 41 Neighboring gene microRNA 9898 Neighboring gene keratin 8 Neighboring gene KRT18 locus control region Neighboring gene eukaryotic translation initiation factor 4B Neighboring gene uncharacterized LOC283335 Neighboring gene tensin 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in adherens junction HDA PubMed 
    located_in cell periphery IEA
    Inferred from Electronic Annotation
    more info
     
    located_in centriolar satellite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in intermediate filament IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in keratin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in keratin filament IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in keratin filament IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in microtubule organizing center IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    keratin, type I cytoskeletal 18
    Names
    cell proliferation-inducing gene 46 protein
    cytokeratin 18
    keratin 18, type I

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008351.1 RefSeqGene

      Range
      5248..9036
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000224.3NP_000215.1  keratin, type I cytoskeletal 18

      See identical proteins and their annotated locations for NP_000215.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC107016, CD106591, X12881
      Consensus CDS
      CCDS31809.1
      UniProtKB/Swiss-Prot
      P05783
      UniProtKB/TrEMBL
      A0A024RAY2
      Related
      ENSP00000373487.3, ENST00000388835.4
      Conserved Domains (1) summary
      pfam00038
      Location:79391
      Filament; Intermediate filament protein
    2. NM_199187.2NP_954657.1  keratin, type I cytoskeletal 18

      See identical proteins and their annotated locations for NP_954657.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC107016, BG753529, CD106591, X12881
      Consensus CDS
      CCDS31809.1
      UniProtKB/Swiss-Prot
      P05783
      UniProtKB/TrEMBL
      A0A024RAY2
      Related
      ENSP00000373489.2, ENST00000388837.6
      Conserved Domains (1) summary
      pfam00038
      Location:79391
      Filament; Intermediate filament protein

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

      Range
      52948855..52952906
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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