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    oaz1.S ornithine decarboxylase antizyme 1 S homeolog [ Xenopus laevis (African clawed frog) ]

    Gene ID: 379737, updated on 27-Jan-2018

    Summary

    Official Symbol
    oaz1.S
    Official Full Name
    ornithine decarboxylase antizyme 1 S homeolog
    Primary source
    Xenbase:XB-GENE-865996
    Locus tag
    XELAEV_18009851mg
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Xenopus laevis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
    Also known as
    oaz; oaz1
    Summary
    The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamine in cells. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis pathway; thus, completing the auto-regulatory circuit. This gene encodes antizyme 1, the first member of the antizyme family, that has broad tissue distribution, and negatively regulates intracellular polyamine levels by binding to and targeting ODC for degradation, as well as by inhibiting polyamine uptake. Antizyme 1 mRNA contains two potential in-frame AUGs, and studies in rat suggest that alternative use of the two translation initiation sites results in N-terminally distinct protein isoforms with different subcellular localization (PMID:16120325). [provided by RefSeq, Jul 2014]
    Orthologs

    Genomic context

    See oaz1.S in Genome Data Viewer
    Location:
    chromosome: 1S
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    100 current Xenopus_laevis_v2 (GCF_001663975.1) 1S NC_030725.1 (88063021..88072621, complement)

    Chromosome 1S - NC_030725.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100495756 S homeolog Neighboring gene leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3 Neighboring gene uncharacterized LOC108706870 Neighboring gene anti-Mullerian hormone S homeolog

    Genomic regions, transcripts, and products

    Genomic Sequence:
    NC_030725.1 Chromosome 1S Reference Xenopus_laevis_v2 Primary Assembly

    Bibliography

    Related articles in PubMed

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    General protein information

    Preferred Names
    ornithine decarboxylase antizyme 1
    Names
    ODC-Az

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001086576.1NP_001080045.1  ornithine decarboxylase antizyme 1

      Status: REVIEWED

      Source sequence(s)
      BC059788
      UniProtKB/TrEMBL
      Q6PBB6
      Conserved Domains (1) summary
      pfam02100
      Location:119207
      ODC_AZ; Ornithine decarboxylase antizyme

    RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 100 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_laevis_v2 Primary Assembly

    Genomic

    1. NC_030725.1 Reference Xenopus_laevis_v2 Primary Assembly

      Range
      88063021..88072621 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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