Format

Send to:

Choose Destination
    • Showing Current items.

    Egfr Epidermal growth factor receptor [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37455, updated on 11-May-2019

    Summary

    Official Symbol
    Egfrprovided by FlyBase
    Official Full Name
    Epidermal growth factor receptorprovided by FlyBase
    Primary source
    FLYBASE:FBgn0003731
    Locus tag
    Dmel_CG10079
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    C-erb; c-erbB; CG10079; D-Egf; d-egf-r; D-EGFR; degfr; dEgfr; dEGFr; dEGFR; Degfr; DEgfr; DEGFR; dEGFR1; der; Der; DER; DER flb; DER/EGFR; DER/top; DER/torpedo; DER1; Dmel\CG10079; DmHD-33; EC2-4; EFG-R; Egf; Egf-r; EGF-R; egfr; EgfR; EGfr; EGFr; EGFR; EK2-6; El; Elp; Elp-1; Elp-B1; Elp-B1RB1; flb; Flb; HD-33; l(2)05351; l(2)09261; l(2)57DEFa; l(2)57Ea; l(2)57EFa; mor1; top; Top; TOP; top/DER; top/flb; Tor; Torpedo/DER; torpedo/egfr; torpedo/Egfr; Torpedo/Egfr

    Genomic context

    See Egfr in Genome Data Viewer
    Location:
    57E9-57F1; 2-95 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.26 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (21522420..21559977)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (17409925..17447482)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44725 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene tiwaz Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    epidermal growth factor-activated receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding IEA
    Inferred from Electronic Annotation
    more info
     
    transmembrane receptor protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    Malpighian tubule morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    behavioral response to ethanol IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    border follicle cell migration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    border follicle cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell projection assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell-cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    chorion-containing eggshell pattern formation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    compound eye cone cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    compound eye development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    compound eye photoreceptor cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    determination of genital disc primordium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    digestive tract morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    dorsal appendage formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    dorsal closure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    dorsal closure, spreading of leading edge cells IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic pattern specification IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    epidermal growth factor receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    epidermal growth factor receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    epidermal growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    epithelial cell proliferation involved in Malpighian tubule morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    establishment or maintenance of apical/basal cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    eye development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    eye-antennal disc morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    germ-band shortening IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    germ-line stem cell population maintenance IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    gonad development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    haltere development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    heart process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    imaginal disc development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    imaginal disc-derived wing morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    imaginal disc-derived wing vein morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    imaginal disc-derived wing vein specification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    leg disc proximal/distal pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    maintenance of epithelial integrity, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    maternal determination of dorsal/ventral axis, ovarian follicular epithelium, soma encoded IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    morphogenesis of an epithelium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    morphogenesis of follicular epithelium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of G1/S transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of apoptotic signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of compound eye retinal cell programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neurogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    notum cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    notum development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    oenocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    olfactory learning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ommatidial rotation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    oocyte axis specification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    peripheral nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    photoreceptor cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    photoreceptor cell fate determination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of border follicle cell migration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of cell division IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of imaginal disc growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of wound healing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    salivary gland development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    second mitotic wave involved in compound eye morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    segment polarity determination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    spiracle morphogenesis, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    stem cell fate commitment IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    tracheal outgrowth, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transmembrane receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    wing and notum subfield formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    wing disc morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    basal plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    colocalizes_with cytoneme IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    integral component of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane HDA PubMed 
    receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    epidermal growth factor receptor
    Names
    CG10079-PA
    CG10079-PB
    DER-Ellipse
    EGF-receptor
    EGFR
    Egf receptor
    Egfr-PA
    Egfr-PB
    dEGFR
    drosophila epidermal growth factor receptor
    drosophila epidermal growth factor receptor homologue
    ellipse
    ellipse torpedo
    faint little ball
    morphological defects 1
    torpedo
    torpedo/DER
    NP_476758.1
    NP_476759.1

    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      21522420..21559977
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057410.4NP_476758.1  epidermal growth factor receptor, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476758.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MLW0
      Related
      FBpp0071570, FBtr0071653
      Conserved Domains (7) summary
      smart00221
      Location:8891145
      STYKc; Protein kinase; unclassified specificity
      smart00261
      Location:568610
      FU; Furin-like repeats
      cd00064
      Location:253296
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
      cd05057
      Location:8811159
      PTKc_EGFR_like; Catalytic domain of Epidermal Growth Factor Receptor-like Protein Tyrosine Kinases
      pfam00757
      Location:204352
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:370498
      Recep_L_domain; Receptor L domain
      pfam14843
      Location:523635
      GF_recep_IV; Growth factor receptor domain IV
    2. NM_057411.4NP_476759.1  epidermal growth factor receptor, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476759.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P04412
      Related
      FBpp0071571, FBtr0071654
      Conserved Domains (7) summary
      smart00221
      Location:9381194
      STYKc; Protein kinase; unclassified specificity
      smart00261
      Location:617659
      FU; Furin-like repeats
      cd00064
      Location:302345
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
      cd05057
      Location:9301208
      PTKc_EGFR_like; Catalytic domain of Epidermal Growth Factor Receptor-like Protein Tyrosine Kinases
      pfam00757
      Location:253401
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:419547
      Recep_L_domain; Receptor L domain
      pfam14843
      Location:572684
      GF_recep_IV; Growth factor receptor domain IV
    Support Center