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    MBL2 mannose binding lectin 2 [ Gallus gallus (chicken) ]

    Gene ID: 374267, updated on 7-Jul-2018

    Summary

    Symbol
    MBL2provided by CGNC
    Full Name
    mannose binding lectin 2provided by CGNC
    Primary source
    CGNC:49110
    See related
    Ensembl:ENSGALG00000002507
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    MBL; MBP; cMBl; collectin

    Genomic context

    See MBL2 in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    104 current GRCg6a (GCF_000002315.5) 6 NC_006093.5 (5215053..5229085, complement)
    103 previous assembly Gallus_gallus-5.0 (GCF_000002315.4) 6 NC_006093.4 (4503081..4511261, complement)

    Chromosome 6 - NC_006093.5Genomic Context describing neighboring genes Neighboring gene surfactant protein A1 Neighboring gene surfactant protein A2 Neighboring gene uncharacterized LOC101752332 Neighboring gene RasGEF domain family member 1A Neighboring gene uncharacterized LOC107053621

    Genomic regions, transcripts, and products

    Pathways from BioSystems

    • Phagosome, organism-specific biosystem (from KEGG)
      Phagosome, organism-specific biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
    • Phagosome, conserved biosystem (from KEGG)
      Phagosome, conserved biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...

    General gene information

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    mannose binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    complement activation, classical pathway IEA
    Inferred from Electronic Annotation
    more info
     
    complement activation, lectin pathway TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    collagen trimer IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular region TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    mannose-binding lectin
    Names
    c-type lectin
    mannan-binding lectin
    mannan-binding protein
    mannose binding lectin, liver (A)
    mannose-binding lectin (protein C) 2, soluble
    mannose-binding protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_204349.2NP_989680.2  mannose-binding lectin precursor

      Status: VALIDATED

      Source sequence(s)
      AADN05000334
      UniProtKB/Swiss-Prot
      Q98TA4
      Related
      ENSGALP00000040351.1, ENSGALT00000041145.3
      Conserved Domains (3) summary
      cd03591
      Location:142254
      CLECT_collectin_like; C-type lectin-like domain (CTLD) of the type found in human collectins including lung surfactant proteins A and D, mannose- or mannan binding lectin (MBL), and CL-L1 (collectin liver 1)
      pfam01391
      Location:47102
      Collagen; Collagen triple helix repeat (20 copies)
      pfam09006
      Location:105149
      Surfac_D-trimer; Lung surfactant protein D coiled-coil trimerisation

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 104 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCg6a Primary Assembly

    Genomic

    1. NC_006093.5 Reference GRCg6a Primary Assembly

      Range
      5215053..5229085 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015287953.2XP_015143439.2  mannose-binding lectin isoform X1

      Conserved Domains (3) summary
      cd03591
      Location:235347
      CLECT_collectin_like; C-type lectin-like domain (CTLD) of the type found in human collectins including lung surfactant proteins A and D, mannose- or mannan binding lectin (MBL), and CL-L1 (collectin liver 1)
      pfam01391
      Location:140195
      Collagen; Collagen triple helix repeat (20 copies)
      pfam09006
      Location:198242
      Surfac_D-trimer; Lung surfactant protein D coiled-coil trimerisation
    2. XM_025151449.1XP_025007217.1  mannose-binding lectin isoform X3

      Conserved Domains (3) summary
      cd03591
      Location:197309
      CLECT_collectin_like; C-type lectin-like domain (CTLD) of the type found in human collectins including lung surfactant proteins A and D, mannose- or mannan binding lectin (MBL), and CL-L1 (collectin liver 1)
      pfam01391
      Location:102157
      Collagen; Collagen triple helix repeat (20 copies)
      pfam09006
      Location:160204
      Surfac_D-trimer; Lung surfactant protein D coiled-coil trimerisation
    3. XM_025151448.1XP_025007216.1  mannose-binding lectin isoform X2

      Conserved Domains (3) summary
      cd03591
      Location:201313
      CLECT_collectin_like; C-type lectin-like domain (CTLD) of the type found in human collectins including lung surfactant proteins A and D, mannose- or mannan binding lectin (MBL), and CL-L1 (collectin liver 1)
      pfam01391
      Location:106159
      Collagen; Collagen triple helix repeat (20 copies)
      pfam09006
      Location:164208
      Surfac_D-trimer; Lung surfactant protein D coiled-coil trimerisation
    4. XM_025151451.1XP_025007219.1  mannose-binding lectin isoform X4

      Conserved Domains (3) summary
      cd03591
      Location:142254
      CLECT_collectin_like; C-type lectin-like domain (CTLD) of the type found in human collectins including lung surfactant proteins A and D, mannose- or mannan binding lectin (MBL), and CL-L1 (collectin liver 1)
      pfam01391
      Location:47102
      Collagen; Collagen triple helix repeat (20 copies)
      pfam09006
      Location:105149
      Surfac_D-trimer; Lung surfactant protein D coiled-coil trimerisation
    5. XM_025151450.1XP_025007218.1  mannose-binding lectin isoform X4

      Conserved Domains (3) summary
      cd03591
      Location:142254
      CLECT_collectin_like; C-type lectin-like domain (CTLD) of the type found in human collectins including lung surfactant proteins A and D, mannose- or mannan binding lectin (MBL), and CL-L1 (collectin liver 1)
      pfam01391
      Location:47102
      Collagen; Collagen triple helix repeat (20 copies)
      pfam09006
      Location:105149
      Surfac_D-trimer; Lung surfactant protein D coiled-coil trimerisation
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