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    Rtel1 regulator of telomere elongation helicase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362288, updated on 2-Jun-2019

    Summary

    Official Symbol
    Rtel1provided by RGD
    Official Full Name
    regulator of telomere elongation helicase 1provided by RGD
    Primary source
    RGD:1306721
    See related
    Ensembl:ENSRNOG00000027513
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1306721
    Expression
    Biased expression in Thymus (RPKM 145.6), Lung (RPKM 115.9) and 9 other tissues See more
    Orthologs

    Genomic context

    See Rtel1 in Genome Data Viewer
    Location:
    3q43
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (176818012..176856531)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 3 NC_005102.3 (180528554..180566701)

    Chromosome 3 - NC_005102.4Genomic Context describing neighboring genes Neighboring gene glucocorticoid modulatory element binding protein 2 Neighboring gene stathmin 3 Neighboring gene ADP-ribosylation factor related protein 1 Neighboring gene zinc finger CCCH-type and G-patch domain containing Neighboring gene Lck interacting transmembrane adaptor 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from BioSystems

    General gene information

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATP binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    ATP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    DNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    DNA helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    DNA polymerase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    DNA polymerase binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    DNA duplex unwinding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    DNA duplex unwinding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA duplex unwinding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    DNA recombination IEA
    Inferred from Electronic Annotation
    more info
     
    DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    DNA replication IEA
    Inferred from Electronic Annotation
    more info
     
    mitotic telomere maintenance via semi-conservative replication IEA
    Inferred from Electronic Annotation
    more info
     
    mitotic telomere maintenance via semi-conservative replication ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of DNA recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of DNA recombination ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of t-circle formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of t-circle formation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of telomere maintenance in response to DNA damage IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of telomere maintenance in response to DNA damage ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of telomere capping ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of telomere maintenance ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of telomere maintenance via telomere lengthening ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of telomeric loop disassembly IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of telomeric loop disassembly ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of double-strand break repair via homologous recombination IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of double-strand break repair via homologous recombination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    replication fork processing IEA
    Inferred from Electronic Annotation
    more info
     
    replication fork processing ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    strand displacement IEA
    Inferred from Electronic Annotation
    more info
     
    strand displacement ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    telomere maintenance IEA
    Inferred from Electronic Annotation
    more info
     
    telomere maintenance ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    telomere maintenance ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    telomere maintenance in response to DNA damage IEA
    Inferred from Electronic Annotation
    more info
     
    telomere maintenance in response to DNA damage ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    telomeric loop disassembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    telomeric loop disassembly ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Component Evidence Code Pubs
    chromosome, telomeric region IEA
    Inferred from Electronic Annotation
    more info
     
    chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    regulator of telomere elongation helicase 1
    Names
    helicase-like protein NHL
    NP_001178786.1
    XP_006235834.1
    XP_006235835.1
    XP_006235836.1
    XP_006235837.1
    XP_006235838.1
    XP_006235840.1
    XP_017447429.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191857.1NP_001178786.1  regulator of telomere elongation helicase 1

      See identical proteins and their annotated locations for NP_001178786.1

      Status: PROVISIONAL

      Source sequence(s)
      AC095847, AC117053
      UniProtKB/Swiss-Prot
      Q5RJZ1
      Related
      ENSRNOP00000051909.3, ENSRNOT00000055030.3
      Conserved Domains (5) summary
      cd13932
      Location:877976
      HN_RTEL1; harmonin_N_like domain of regulator of telomere elongation helicase 1 (also known as RTEL)
      TIGR00604
      Location:10743
      rad3; DNA repair helicase (rad3)
      pfam06733
      Location:111272
      DEAD_2; DEAD_2
      pfam13307
      Location:545731
      Helicase_C_2; Helicase C-terminal domain
      cl21455
      Location:1586
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005102.4 Reference Rnor_6.0 Primary Assembly

      Range
      176818012..176856531
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006235773.3XP_006235835.1  regulator of telomere elongation helicase 1 isoform X1

      See identical proteins and their annotated locations for XP_006235835.1

      UniProtKB/TrEMBL
      A0A0G2JVG0
      Related
      ENSRNOP00000069471.1, ENSRNOT00000087279.1
      Conserved Domains (5) summary
      cd13932
      Location:877976
      HN_RTEL1; harmonin_N_like domain of regulator of telomere elongation helicase 1 (also known as RTEL)
      TIGR00604
      Location:10743
      rad3; DNA repair helicase (rad3)
      pfam06733
      Location:111272
      DEAD_2; DEAD_2
      pfam13307
      Location:545731
      Helicase_C_2; Helicase C-terminal domain
      cl21455
      Location:1586
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    2. XM_006235772.3XP_006235834.1  regulator of telomere elongation helicase 1 isoform X1

      See identical proteins and their annotated locations for XP_006235834.1

      UniProtKB/TrEMBL
      A0A0G2JVG0
      Conserved Domains (5) summary
      cd13932
      Location:877976
      HN_RTEL1; harmonin_N_like domain of regulator of telomere elongation helicase 1 (also known as RTEL)
      TIGR00604
      Location:10743
      rad3; DNA repair helicase (rad3)
      pfam06733
      Location:111272
      DEAD_2; DEAD_2
      pfam13307
      Location:545731
      Helicase_C_2; Helicase C-terminal domain
      cl21455
      Location:1586
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    3. XM_006235774.3XP_006235836.1  regulator of telomere elongation helicase 1 isoform X2

      Conserved Domains (5) summary
      cd13932
      Location:877976
      HN_RTEL1; harmonin_N_like domain of regulator of telomere elongation helicase 1 (also known as RTEL)
      TIGR00604
      Location:10743
      rad3; DNA repair helicase (rad3)
      pfam06733
      Location:111272
      DEAD_2; DEAD_2
      pfam13307
      Location:545731
      Helicase_C_2; Helicase C-terminal domain
      cl21455
      Location:1586
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    4. XM_006235775.3XP_006235837.1  regulator of telomere elongation helicase 1 isoform X3

      Conserved Domains (5) summary
      cd13932
      Location:877976
      HN_RTEL1; harmonin_N_like domain of regulator of telomere elongation helicase 1 (also known as RTEL)
      TIGR00604
      Location:10743
      rad3; DNA repair helicase (rad3)
      pfam06733
      Location:111272
      DEAD_2; DEAD_2
      pfam13307
      Location:545731
      Helicase_C_2; Helicase C-terminal domain
      cl21455
      Location:1586
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    5. XM_006235776.3XP_006235838.1  regulator of telomere elongation helicase 1 isoform X4

      Conserved Domains (5) summary
      cd13932
      Location:877976
      HN_RTEL1; harmonin_N_like domain of regulator of telomere elongation helicase 1 (also known as RTEL)
      TIGR00604
      Location:10743
      rad3; DNA repair helicase (rad3)
      pfam06733
      Location:111272
      DEAD_2; DEAD_2
      pfam13307
      Location:545731
      Helicase_C_2; Helicase C-terminal domain
      cl21455
      Location:1586
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    6. XM_017591940.1XP_017447429.1  regulator of telomere elongation helicase 1 isoform X5

    7. XM_006235778.3XP_006235840.1  regulator of telomere elongation helicase 1 isoform X6

      Conserved Domains (4) summary
      cd13932
      Location:654753
      HN_RTEL1; harmonin_N_like domain of regulator of telomere elongation helicase 1 (also known as RTEL)
      TIGR00604
      Location:12520
      rad3; DNA repair helicase (rad3)
      pfam13307
      Location:322508
      Helicase_C_2; Helicase C-terminal domain
      cl21455
      Location:1049
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    Alternate Rn_Celera

    Genomic

    1. AC_000071.1 Alternate Rn_Celera

      Range
      164121122..164155994 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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