Format

Send to:

Choose Destination
    • Showing Current items.

    Tp53inp2 tumor protein p53 inducible nuclear protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362246, updated on 2-Oct-2018

    Summary

    Official Symbol
    Tp53inp2provided by RGD
    Official Full Name
    tumor protein p53 inducible nuclear protein 2provided by RGD
    Primary source
    RGD:735085
    See related
    Ensembl:ENSRNOG00000018225
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Trp53inp2
    Summary
    human homolog is expressed in response to a germline translocation associated with familial urothelial carcinoma [RGD, Feb 2006]
    Expression
    Biased expression in Heart (RPKM 308.4), Muscle (RPKM 289.2) and 9 other tissues See more
    Orthologs

    Genomic context

    See Tp53inp2 in Genome Data Viewer
    Location:
    3q41
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (150910398..150918525)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 3 NC_005102.3 (157278515..157286642)

    Chromosome 3 - NC_005102.4Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class U Neighboring gene uncharacterized LOC108350506 Neighboring gene microRNA 6334 Neighboring gene nuclear receptor coactivator 6 Neighboring gene uncharacterized LOC103691943

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from BioSystems

    • Autophagy - animal, organism-specific biosystem (from KEGG)
      Autophagy - animal, organism-specific biosystemAutophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily cons...
    • Autophagy - animal, conserved biosystem (from KEGG)
      Autophagy - animal, conserved biosystemAutophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily cons...

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    ubiquitin binding IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    autophagosome assembly IEA
    Inferred from Electronic Annotation
    more info
     
    autophagosome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    autophagosome assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    macroautophagy ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cellular protein localization IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cellular protein localization ISO
    Inferred from Sequence Orthology
    more info
     
    osteoblast differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of autophagy IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription, DNA-templated IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    tissue homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    tissue homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    PML body IEA
    Inferred from Electronic Annotation
    more info
     
    autophagosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    autophagosome IEA
    Inferred from Electronic Annotation
    more info
     
    autophagosome ISO
    Inferred from Sequence Orthology
    more info
     
    autophagosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    tumor protein p53-inducible nuclear protein 2
    Names
    diabetes and obesity-regulated

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001270947.1NP_001257876.1  tumor protein p53-inducible nuclear protein 2

      See identical proteins and their annotated locations for NP_001257876.1

      Status: PROVISIONAL

      Source sequence(s)
      AABR07072941
      UniProtKB/TrEMBL
      G3V9L6
      Related
      ENSRNOP00000052180.2, ENSRNOT00000055310.4
      Conserved Domains (1) summary
      pfam14839
      Location:67212
      DOR; DOR family

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005102.4 Reference Rnor_6.0 Primary Assembly

      Range
      150910398..150918525
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006235327.2XP_006235389.1  tumor protein p53-inducible nuclear protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006235389.1

      UniProtKB/TrEMBL
      G3V9L6
      Conserved Domains (1) summary
      pfam14839
      Location:67212
      DOR; DOR family
    2. XM_003749598.3XP_003749646.1  tumor protein p53-inducible nuclear protein 2 isoform X1

      See identical proteins and their annotated locations for XP_003749646.1

      UniProtKB/TrEMBL
      G3V9L6
      Conserved Domains (1) summary
      pfam14839
      Location:67212
      DOR; DOR family

    Alternate Rn_Celera

    Genomic

    1. AC_000071.1 Alternate Rn_Celera

      Range
      142607828..142615961
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center