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    Fga fibrinogen alpha chain [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361969, updated on 19-Apr-2019

    Summary

    Official Symbol
    Fgaprovided by RGD
    Official Full Name
    fibrinogen alpha chainprovided by RGD
    Primary source
    RGD:2603
    See related
    Ensembl:ENSRNOG00000024848
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Fba5e; Ac1873
    Summary
    plays a role in blood coagulation; may be involved in liver regeneration [RGD, Feb 2006]
    Expression
    Restricted expression toward (RPKM 13599.1) See more
    Orthologs

    Genomic context

    See Fga in Genome Data Viewer
    Location:
    2q34
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (181997562..182013726)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 2 NC_005101.3 (201412182..201428346)

    Chromosome 2 - NC_005101.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102556113 Neighboring gene fibrinogen gamma chain Neighboring gene fibrinogen beta chain Neighboring gene pleiotropic regulator 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Clone Names

    • MGC156536

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    cell adhesion molecule binding IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to cell adhesion molecule binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    molecular_function ND
    No biological Data available
    more info
     
    signaling receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
     
    structural molecule activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Process Evidence Code Pubs
    acute-phase response IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
     
    blood coagulation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    blood coagulation TAS
    Traceable Author Statement
    more info
    PubMed 
    blood coagulation, common pathway IEA
    Inferred from Electronic Annotation
    more info
     
    blood coagulation, common pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    blood coagulation, fibrin clot formation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cell-matrix adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    cell-matrix adhesion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cellular protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cellular response to granulocyte colony-stimulating factor IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to interleukin-6 IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to organic cyclic compound IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    envenomation resulting in modulation of blood coagulation in other organism IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    fibrinolysis IEA
    Inferred from Electronic Annotation
    more info
     
    fibrinolysis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    induction of bacterial agglutination IEA
    Inferred from Electronic Annotation
    more info
     
    induction of bacterial agglutination ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    liver regeneration IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    negative regulation of endothelial cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of endothelial cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of extrinsic apoptotic signaling pathway via death domain receptors ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    plasminogen activation IEA
    Inferred from Electronic Annotation
    more info
     
    plasminogen activation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    platelet activation IEA
    Inferred from Electronic Annotation
    more info
     
    platelet aggregation IEA
    Inferred from Electronic Annotation
    more info
     
    platelet aggregation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of exocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of exocytosis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of heterotypic cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of heterotypic cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of peptide hormone secretion IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of peptide hormone secretion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of protein secretion IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of protein secretion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of smooth muscle cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of vasoconstriction IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of vasoconstriction ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein polymerization IEA
    Inferred from Electronic Annotation
    more info
     
    protein polymerization ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    response to X-ray IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to calcium ion IEA
    Inferred from Electronic Annotation
    more info
     
    response to calcium ion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    response to cycloheximide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to estradiol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to genistein IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to growth hormone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to insulin IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to morphine IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to thyroid hormone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to toxic substance IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    blood microparticle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell cortex IEA
    Inferred from Electronic Annotation
    more info
     
    cell cortex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cell surface ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    fibrinogen complex IEA
    Inferred from Electronic Annotation
    more info
     
    fibrinogen complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    platelet alpha granule IEA
    Inferred from Electronic Annotation
    more info
     
    platelet alpha granule ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    rough endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    synapse IEA
    Inferred from Electronic Annotation
    more info
     
    synapse ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    fibrinogen alpha chain
    Names
    fibrinogen, A alpha polypeptide
    fibrinogen, alpha polypeptide

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008724.1NP_001008724.1  fibrinogen alpha chain isoform 1 precursor

      See identical proteins and their annotated locations for NP_001008724.1

      Status: PROVISIONAL

      Source sequence(s)
      AY310161
      UniProtKB/TrEMBL
      Q7TQ70
      Conserved Domains (3) summary
      cd00087
      Location:546779
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
      pfam08702
      Location:51189
      Fib_alpha; Fibrinogen alpha/beta chain family
      pfam12160
      Location:388453
      Fibrinogen_aC; Fibrinogen alpha C domain
    2. NM_052797.1NP_434684.1  fibrinogen alpha chain isoform 2 precursor

      See identical proteins and their annotated locations for NP_434684.1

      Status: PROVISIONAL

      Source sequence(s)
      BC127465
      UniProtKB/TrEMBL
      A1L114
      Conserved Domains (2) summary
      pfam08702
      Location:51189
      Fib_alpha; Fibrinogen alpha/beta chain family
      pfam12160
      Location:388453
      Fibrinogen_aC; Fibrinogen alpha C domain

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005101.4 Reference Rnor_6.0 Primary Assembly

      Range
      181997562..182013726
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006232533.3XP_006232595.1  fibrinogen alpha chain isoform X2

      See identical proteins and their annotated locations for XP_006232595.1

      UniProtKB/TrEMBL
      Q7TQ70
      Related
      ENSRNOP00000060007.2, ENSRNOT00000064091.3
      Conserved Domains (3) summary
      cd00087
      Location:546779
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
      pfam08702
      Location:51189
      Fib_alpha; Fibrinogen alpha/beta chain family
      pfam12160
      Location:388453
      Fibrinogen_aC; Fibrinogen alpha C domain
    2. XM_006232532.3XP_006232594.1  fibrinogen alpha chain isoform X1

      Conserved Domains (3) summary
      cd00087
      Location:549782
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
      pfam08702
      Location:54192
      Fib_alpha; Fibrinogen alpha/beta chain family
      pfam12160
      Location:391456
      Fibrinogen_aC; Fibrinogen alpha C domain

    Alternate Rn_Celera

    Genomic

    1. AC_000070.1 Alternate Rn_Celera

      Range
      162392064..162408023
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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