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    Chmp4c charged multivesicular body protein 4C [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361916, updated on 18-Apr-2019

    Summary

    Official Symbol
    Chmp4cprovided by RGD
    Official Full Name
    charged multivesicular body protein 4Cprovided by RGD
    Primary source
    RGD:1564543
    See related
    Ensembl:ENSRNOG00000010238
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Expression
    Biased expression in Kidney (RPKM 153.5), Liver (RPKM 81.7) and 8 other tissues See more
    Orthologs

    Genomic context

    See Chmp4c in Genome Data Viewer
    Location:
    2q23
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (93574554..93641497, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 2 NC_005101.3 (113397120..113397419, complement) , (113334155..113340595, complement)

    Chromosome 2 - NC_005101.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103691511 Neighboring gene sorting nexin 16 Neighboring gene zinc finger AN1-type containing 1 Neighboring gene solute carrier family 10, member 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Clone Names

    • MGC108776

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Process Evidence Code Pubs
    abscission IEA
    Inferred from Electronic Annotation
    more info
     
    abscission ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    abscission ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    midbody abscission IEA
    Inferred from Electronic Annotation
    more info
     
    midbody abscission ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    mitotic cytokinesis checkpoint IEA
    Inferred from Electronic Annotation
    more info
     
    mitotic cytokinesis checkpoint ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    mitotic cytokinesis checkpoint ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    mitotic metaphase plate congression IEA
    Inferred from Electronic Annotation
    more info
     
    mitotic metaphase plate congression ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of cytokinesis IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cytokinesis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of cytokinesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    nucleus organization IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus organization ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of viral release from host cell IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of viral release from host cell ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of centrosome duplication IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of centrosome duplication ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of mitotic spindle assembly IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of mitotic spindle assembly ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of viral process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    vacuolar transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Flemming body IEA
    Inferred from Electronic Annotation
    more info
     
    Flemming body ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    late endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    midbody ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    charged multivesicular body protein 4c
    Names
    Snf7 homologue associated with Alix 3
    chromatin modifying protein 4C
    chromatin-modifying protein 4c

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001017466.2NP_001017466.2  charged multivesicular body protein 4c

      Status: VALIDATED

      Source sequence(s)
      BC092576, CO383495
      UniProtKB/Swiss-Prot
      Q569C1
      UniProtKB/TrEMBL
      F1LPT7
      Related
      ENSRNOP00000013720.4, ENSRNOT00000013720.5
      Conserved Domains (1) summary
      pfam03357
      Location:24190
      Snf7; Snf7

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005101.4 Reference Rnor_6.0 Primary Assembly

      Range
      93574554..93641497 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000070.1 Alternate Rn_Celera

      Range
      86994242..87031805 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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