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    Cyp2r1 cytochrome P450, family 2, subfamily r, polypeptide 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361631, updated on 19-Apr-2019

    Summary

    Official Symbol
    Cyp2r1provided by RGD
    Official Full Name
    cytochrome P450, family 2, subfamily r, polypeptide 1provided by RGD
    Primary source
    RGD:1311866
    See related
    Ensembl:ENSRNOG00000011367
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Expression
    Biased expression in Kidney (RPKM 60.0), Liver (RPKM 49.3) and 9 other tissues See more
    Orthologs

    Genomic context

    See Cyp2r1 in Genome Data Viewer
    Location:
    1q34
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (184060521..184106604, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (191032655..191078746, complement)

    Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102548665 Neighboring gene proteasome subunit alpha 1 Neighboring gene ubiquitin-like protein FUBI-like Neighboring gene phosphodiesterase 3B Neighboring gene uncharacterized LOC108349622 Neighboring gene calcitonin-related polypeptide alpha Neighboring gene calcitonin-related polypeptide, beta

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    heme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    iron ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    molecular_function ND
    No biological Data available
    more info
     
    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    steroid hydroxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    vitamin D3 25-hydroxylase activity IEA
    Inferred from Electronic Annotation
    more info
     
    vitamin D3 25-hydroxylase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Process Evidence Code Pubs
    calcitriol biosynthetic process from calciol IEA
    Inferred from Electronic Annotation
    more info
     
    calcitriol biosynthetic process from calciol ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    exogenous drug catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    organic acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    oxidation-reduction process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    response to cesium ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to ionizing radiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to metal ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    vitamin D metabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    xenobiotic metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    vitamin D 25-hydroxylase
    NP_001101969.1
    XP_006230143.1
    XP_006230144.1
    XP_006230146.1
    XP_008757991.1
    XP_017444878.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108499.1NP_001101969.1  vitamin D 25-hydroxylase

      See identical proteins and their annotated locations for NP_001101969.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473956
      Conserved Domains (1) summary
      cl12078
      Location:5195
      p450; Cytochrome P450

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

      Range
      184060521..184106604 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006230082.3XP_006230144.1  vitamin D 25-hydroxylase isoform X3

      Conserved Domains (1) summary
      pfam00067
      Location:65469
      p450; Cytochrome P450
    2. XM_008759769.2XP_008757991.1  vitamin D 25-hydroxylase isoform X2

      Conserved Domains (1) summary
      pfam00067
      Location:65467
      p450; Cytochrome P450
    3. XM_017589389.1XP_017444878.1  vitamin D 25-hydroxylase isoform X4

    4. XM_006230081.3XP_006230143.1  vitamin D 25-hydroxylase isoform X1

      Related
      ENSRNOP00000063152.3, ENSRNOT00000067609.3
      Conserved Domains (1) summary
      pfam00067
      Location:65516
      p450; Cytochrome P450
    5. XM_006230084.3XP_006230146.1  vitamin D 25-hydroxylase isoform X5

      Conserved Domains (1) summary
      pfam00067
      Location:2417
      p450; Cytochrome P450

    Alternate Rn_Celera

    Genomic

    1. AC_000069.1 Alternate Rn_Celera

      Range
      166625863..166638315 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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