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    Svil supervillin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361256, updated on 21-Jul-2018

    Summary

    Official Symbol
    Svilprovided by RGD
    Official Full Name
    supervillinprovided by RGD
    Primary source
    RGD:1306354
    See related
    Ensembl:ENSRNOG00000018110
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Expression
    Biased expression in Muscle (RPKM 505.9), Heart (RPKM 236.6) and 7 other tissues See more
    Orthologs

    Genomic context

    See Svil in Genome Data Viewer
    Location:
    17q12.1
    Exon count:
    45
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (55230298..55425967, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 17 NC_005116.3 (52915519..53109502, complement)

    Chromosome 17 - NC_005116.4Genomic Context describing neighboring genes Neighboring gene zinc finger protein 438 Neighboring gene NADH dehydrogenase (ubiquinone) 1 beta subcomplex 3-like Neighboring gene uncharacterized LOC108348573 Neighboring gene similar to ribosomal protein S24 Neighboring gene uncharacterized LOC102556228

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    actin filament binding IEA
    Inferred from Electronic Annotation
    more info
     
    actin filament binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
     
    skeletal muscle tissue development IEA
    Inferred from Electronic Annotation
    more info
     
    skeletal muscle tissue development ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    costamere IEA
    Inferred from Electronic Annotation
    more info
     
    costamere ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108416.2NP_001101886.2  supervillin

      See identical proteins and their annotated locations for NP_001101886.2

      Status: VALIDATED

      Source sequence(s)
      AABR07028061, AABR07028062, AABR07028063, AABR07028066
      UniProtKB/TrEMBL
      F1M155
      Related
      ENSRNOP00000025037.7, ENSRNOT00000025037.8
      Conserved Domains (6) summary
      smart00153
      Location:21302165
      VHP; Villin headpiece domain
      cd11280
      Location:15141614
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:18301935
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:13931489
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:16971810
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:19522074
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005116.4 Reference Rnor_6.0 Primary Assembly

      Range
      55230298..55425967 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008771739.2XP_008769961.1  supervillin isoform X7

      See identical proteins and their annotated locations for XP_008769961.1

      Conserved Domains (6) summary
      smart00153
      Location:21732208
      VHP; Villin headpiece domain
      cd11280
      Location:15571657
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:18731978
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:14361532
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:17401853
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:19952117
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
    2. XM_006254030.3XP_006254092.1  supervillin isoform X7

      See identical proteins and their annotated locations for XP_006254092.1

      Conserved Domains (6) summary
      smart00153
      Location:21732208
      VHP; Villin headpiece domain
      cd11280
      Location:15571657
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:18731978
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:14361532
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:17401853
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:19952117
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
    3. XM_008771737.2XP_008769959.1  supervillin isoform X7

      See identical proteins and their annotated locations for XP_008769959.1

      Conserved Domains (6) summary
      smart00153
      Location:21732208
      VHP; Villin headpiece domain
      cd11280
      Location:15571657
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:18731978
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:14361532
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:17401853
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:19952117
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
    4. XM_006254031.3XP_006254093.1  supervillin isoform X7

      See identical proteins and their annotated locations for XP_006254093.1

      Conserved Domains (6) summary
      smart00153
      Location:21732208
      VHP; Villin headpiece domain
      cd11280
      Location:15571657
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:18731978
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:14361532
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:17401853
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:19952117
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
    5. XM_017600620.1XP_017456109.1  supervillin isoform X6

    6. XM_017600627.1XP_017456116.1  supervillin isoform X14

      Conserved Domains (6) summary
      smart00153
      Location:17311766
      VHP; Villin headpiece domain
      cd11280
      Location:11151215
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:14311536
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:9941090
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:12981411
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:15531675
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
    7. XM_017600626.1XP_017456115.1  supervillin isoform X13

    8. XM_017600625.1XP_017456114.1  supervillin isoform X12

      Conserved Domains (6) summary
      smart00153
      Location:18051840
      VHP; Villin headpiece domain
      cd11280
      Location:11891289
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:15051610
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:10681164
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:13721485
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:16271749
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
    9. XM_017600622.1XP_017456111.1  supervillin isoform X9

    10. XM_017600623.1XP_017456112.1  supervillin isoform X10

    11. XM_017600615.1XP_017456104.1  supervillin isoform X1

      Conserved Domains (6) summary
      smart00153
      Location:21722207
      VHP; Villin headpiece domain
      cd11280
      Location:15561656
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:18721977
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:14351531
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:17391852
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:19942116
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
    12. XM_017600624.1XP_017456113.1  supervillin isoform X11

      Conserved Domains (6) summary
      smart00153
      Location:18331868
      VHP; Villin headpiece domain
      cd11280
      Location:12171317
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:15331638
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:10961192
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:14001513
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:16551777
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
    13. XM_017600621.1XP_017456110.1  supervillin isoform X8

      UniProtKB/TrEMBL
      D3ZEZ9
      Related
      ENSRNOP00000062712.3, ENSRNOT00000064331.4
    14. XM_017600619.1XP_017456108.1  supervillin isoform X5

      Conserved Domains (6) summary
      smart00153
      Location:21182153
      VHP; Villin headpiece domain
      cd11280
      Location:15021602
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:18181923
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:13811477
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:16851798
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:19402062
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
    15. XM_017600617.1XP_017456106.1  supervillin isoform X3

      Conserved Domains (6) summary
      smart00153
      Location:21412176
      VHP; Villin headpiece domain
      cd11280
      Location:15251625
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:18411946
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:14041500
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:17081821
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:19632085
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
    16. XM_017600618.1XP_017456107.1  supervillin isoform X4

      Conserved Domains (6) summary
      smart00153
      Location:21312166
      VHP; Villin headpiece domain
      cd11280
      Location:15151615
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:18311936
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:13941490
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:16981811
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:19532075
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
    17. XM_017600616.1XP_017456105.1  supervillin isoform X2

      Conserved Domains (6) summary
      smart00153
      Location:21472182
      VHP; Villin headpiece domain
      cd11280
      Location:15311631
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:18471952
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:14101506
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:17141827
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:19692091
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

    Alternate Rn_Celera

    Genomic

    1. AC_000085.1 Alternate Rn_Celera

      Range
      48653106..48767953 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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