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    Arhgdia Rho GDP dissociation inhibitor alpha [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360678, updated on 2-May-2024

    Summary

    Official Symbol
    Arhgdiaprovided by RGD
    Official Full Name
    Rho GDP dissociation inhibitor alphaprovided by RGD
    Primary source
    RGD:1359547
    See related
    Ensembl:ENSRNOG00000036688 AllianceGenome:RGD:1359547
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Bles01; Rho GDI 1
    Summary
    Enables Hsp90 protein binding activity; enzyme binding activity; and fatty acid binding activity. Involved in several processes, including cellular response to mechanical stimulus; cellular response to redox state; and regulation of cell shape. Located in cytosol; extracellular space; and membrane. Is active in synapse. Biomarker of hypertension. Human ortholog(s) of this gene implicated in nephrotic syndrome type 8. Orthologous to human ARHGDIA (Rho GDP dissociation inhibitor alpha). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 669.8), Thymus (RPKM 641.1) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Arhgdia in Genome Data Viewer
    Location:
    10q32.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (106352858..106356347, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (105854526..105858020, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (109754012..109757506, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene prolyl 4-hydroxylase subunit beta Neighboring gene H/ACA ribonucleoprotein complex subunit 3 pseudogene Neighboring gene Aly/REF export factor Neighboring gene anaphase promoting complex subunit 11 Neighboring gene neuropeptide B

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Clone Names

    • MGC94886

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables Hsp90 protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables Rho GDP-dissociation inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables Rho GDP-dissociation inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables Rho GDP-dissociation inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables fatty acid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in Schaffer collateral - CA1 synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in immunological synapse ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    rho GDP-dissociation inhibitor 1
    Names
    Rho GDP dissociation inhibitor (GDI) alpha
    rho-GDI alpha

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007005.1NP_001007006.1  rho GDP-dissociation inhibitor 1

      See identical proteins and their annotated locations for NP_001007006.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083817
      UniProtKB/Swiss-Prot
      Q5XI73
      UniProtKB/TrEMBL
      A6HLF5
      Conserved Domains (1) summary
      pfam02115
      Location:11201
      Rho_GDI; RHO protein GDP dissociation inhibitor

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      106352858..106356347 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006247897.5XP_006247959.1  rho GDP-dissociation inhibitor 1 isoform X1

      See identical proteins and their annotated locations for XP_006247959.1

      UniProtKB/Swiss-Prot
      Q5XI73
      UniProtKB/TrEMBL
      A6HLF5
      Conserved Domains (1) summary
      pfam02115
      Location:11201
      Rho_GDI; RHO protein GDP dissociation inhibitor
    2. XM_006247898.4XP_006247960.1  rho GDP-dissociation inhibitor 1 isoform X1

      See identical proteins and their annotated locations for XP_006247960.1

      UniProtKB/Swiss-Prot
      Q5XI73
      UniProtKB/TrEMBL
      A6HLF5
      Related
      ENSRNOP00000080561.1
      Conserved Domains (1) summary
      pfam02115
      Location:11201
      Rho_GDI; RHO protein GDP dissociation inhibitor