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    Ppp1r1b protein phosphatase 1, regulatory (inhibitor) subunit 1B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360616, updated on 18-Apr-2019

    Summary

    Official Symbol
    Ppp1r1bprovided by RGD
    Official Full Name
    protein phosphatase 1, regulatory (inhibitor) subunit 1Bprovided by RGD
    Primary source
    RGD:621859
    See related
    Ensembl:ENSRNOG00000028404
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Darpp32; Darpp-32
    Summary
    potent inhibitor of protein phosphatase 1 (PP1); may play a role in maintaining the levels of excitability of NMDA receptors [RGD, Feb 2006]
    Expression
    Biased expression in Brain (RPKM 199.2), Kidney (RPKM 43.7) and 2 other tissues See more
    Orthologs

    Genomic context

    See Ppp1r1b in Genome Data Viewer
    Location:
    10q31
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (86303727..86312770)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 10 NC_005109.3 (86100811..86109854)

    Chromosome 10 - NC_005109.4Genomic Context describing neighboring genes Neighboring gene hippyragranin Neighboring gene neuronal differentiation 2 Neighboring gene StAR-related lipid transfer domain containing 3 Neighboring gene titin-cap

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Alcoholism, organism-specific biosystem (from KEGG)
      Alcoholism, organism-specific biosystemAlcoholism, also called dependence on alcohol (ethanol), is a chronic relapsing disorder that is progressive and has serious detrimental health outcomes. As one of the primary mediators of the reward...
    • Alcoholism, conserved biosystem (from KEGG)
      Alcoholism, conserved biosystemAlcoholism, also called dependence on alcohol (ethanol), is a chronic relapsing disorder that is progressive and has serious detrimental health outcomes. As one of the primary mediators of the reward...
    • Amphetamine addiction, organism-specific biosystem (from KEGG)
      Amphetamine addiction, organism-specific biosystemAmphetamine is a psychostimulant drug that exerts persistent addictive effects. Most addictive drugs increase extracellular concentrations of dopamine (DA) in nucleus accumbens (NAc) and medial prefr...
    • Amphetamine addiction, conserved biosystem (from KEGG)
      Amphetamine addiction, conserved biosystemAmphetamine is a psychostimulant drug that exerts persistent addictive effects. Most addictive drugs increase extracellular concentrations of dopamine (DA) in nucleus accumbens (NAc) and medial prefr...
    • Cocaine addiction, organism-specific biosystem (from KEGG)
      Cocaine addiction, organism-specific biosystemDrug addiction is a chronic, relapsing disorder in which compulsive drug-seeking and drug-taking behavior persists despite serious negative consequences.There is strong evidence that the dopaminergic...
    • Cocaine addiction, conserved biosystem (from KEGG)
      Cocaine addiction, conserved biosystemDrug addiction is a chronic, relapsing disorder in which compulsive drug-seeking and drug-taking behavior persists despite serious negative consequences.There is strong evidence that the dopaminergic...
    • DARPP-32 events, organism-specific biosystem (from REACTOME)
      DARPP-32 events, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Dopaminergic synapse, organism-specific biosystem (from KEGG)
      Dopaminergic synapse, organism-specific biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
    • Dopaminergic synapse, conserved biosystem (from KEGG)
      Dopaminergic synapse, conserved biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
    • Opioid Signalling, organism-specific biosystem (from REACTOME)
      Opioid Signalling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • cAMP signaling pathway, organism-specific biosystem (from KEGG)
      cAMP signaling pathway, organism-specific biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
    • cAMP signaling pathway, conserved biosystem (from KEGG)
      cAMP signaling pathway, conserved biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    D1 dopamine receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    D2 dopamine receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    D3 dopamine receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    D4 dopamine receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    D5 dopamine receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein phosphatase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein phosphatase inhibitor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    behavioral response to cocaine IEA
    Inferred from Electronic Annotation
    more info
     
    behavioral response to cocaine ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    histone H3-S10 phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    intracellular signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    locomotory behavior IDA
    Inferred from Direct Assay
    more info
    PubMed 
    locomotory behavior ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of female receptivity IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of female receptivity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of phosphoprotein phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    response to amphetamine IEA
    Inferred from Electronic Annotation
    more info
     
    response to amphetamine ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    response to cocaine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to morphine IEA
    Inferred from Electronic Annotation
    more info
     
    response to morphine ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    response to nicotine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    visual learning IEA
    Inferred from Electronic Annotation
    more info
     
    visual learning ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    dendritic spine head IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dendritic spine neck IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
     
    neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    postsynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    protein phosphatase 1 regulatory subunit 1B
    Names
    dopamine- and cAMP-regulated neuronal phosphoprotein
    dopamine- and cAMP-regulated phosphoprotein DARPP-32
    neuronal phosphoprotein DARPP-32
    NP_612530.1
    XP_006247406.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_138521.1NP_612530.1  protein phosphatase 1 regulatory subunit 1B

      See identical proteins and their annotated locations for NP_612530.1

      Status: PROVISIONAL

      Source sequence(s)
      AY601872
      UniProtKB/Swiss-Prot
      Q6J4I0
      Related
      ENSRNOP00000034614.3, ENSRNOT00000037752.3
      Conserved Domains (1) summary
      pfam05395
      Location:2112
      DARPP-32; Protein phosphatase inhibitor 1/DARPP-32

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005109.4 Reference Rnor_6.0 Primary Assembly

      Range
      86303727..86312770
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006247344.3XP_006247406.1  protein phosphatase 1 regulatory subunit 1B isoform X1

      Conserved Domains (1) summary
      pfam05395
      Location:118150
      DARPP-32; Protein phosphatase inhibitor 1/DARPP-32

    Alternate Rn_Celera

    Genomic

    1. AC_000078.1 Alternate Rn_Celera

      Range
      82095371..82102275
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. NW_001091512.1 Alternate Rn_Celera

      Range
      555..1515 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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