Format

Send to:

Choose Destination
    • Showing Current items.

    Myrip myosin VIIA and Rab interacting protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360034, updated on 21-Jul-2018

    Summary

    Official Symbol
    Myripprovided by RGD
    Official Full Name
    myosin VIIA and Rab interacting proteinprovided by RGD
    Primary source
    RGD:727731
    See related
    Ensembl:ENSRNOG00000018797
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Slac2c
    Summary
    human and mouse homologs form a complex with Rab27A and Myosin VIIa; involved in melanosome trafficking to the actin cytoskeleton [RGD, Feb 2006]
    Expression
    Biased expression in Brain (RPKM 68.6), Lung (RPKM 45.8) and 7 other tissues See more
    Orthologs

    Genomic context

    See Myrip in Genome Data Viewer
    Location:
    8q32
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (128972307..129139257)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 8 NC_005107.3 (128171783..128337841)

    Chromosome 8 - NC_005107.4Genomic Context describing neighboring genes Neighboring gene similar to mitochondrial ribosome recycling factor Neighboring gene uncharacterized LOC102549350 Neighboring gene uncharacterized LOC108351802 Neighboring gene uncharacterized LOC108351803 Neighboring gene eukaryotic translation initiation factor 1B

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    Rab GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Rab GTPase binding IEA
    Inferred from Electronic Annotation
    more info
     
    Rab GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    actin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    actin binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    myosin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    myosin binding IEA
    Inferred from Electronic Annotation
    more info
     
    myosin binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase A binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein kinase A binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase A binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of insulin secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cortical actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    dense core granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    exocyst IEA
    Inferred from Electronic Annotation
    more info
     
    exocyst ISO
    Inferred from Sequence Orthology
    more info
     
    melanosome IEA
    Inferred from Electronic Annotation
    more info
     
    melanosome ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    photoreceptor outer segment IEA
    Inferred from Electronic Annotation
    more info
     
    photoreceptor outer segment ISO
    Inferred from Sequence Orthology
    more info
     
    secretory granule membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    synapse IEA
    Inferred from Electronic Annotation
    more info
     
    synapse ISO
    Inferred from Sequence Orthology
    more info
     
    transport vesicle IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    rab effector MyRIP
    Names
    exophilin-8
    myosin-VIIa- and Rab-interacting protein
    slaC2-c
    slp homolog lacking C2 domains c
    synaptotagmin-like protein lacking C2 domains C

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_182844.1NP_878264.1  rab effector MyRIP

      See identical proteins and their annotated locations for NP_878264.1

      Status: PROVISIONAL

      Source sequence(s)
      AY331984
      UniProtKB/Swiss-Prot
      Q7TNY7
      Conserved Domains (2) summary
      pfam02318
      Location:8125
      FYVE_2; FYVE-type zinc finger
      pfam04698
      Location:152856
      Rab_eff_C; Rab effector MyRIP/melanophilin C-terminus

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005107.4 Reference Rnor_6.0 Primary Assembly

      Range
      128972307..129139257
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006244110.3XP_006244172.1  rab effector MyRIP isoform X1

      UniProtKB/TrEMBL
      D3ZTL2
      Related
      ENSRNOP00000025460.6, ENSRNOT00000025460.7
      Conserved Domains (2) summary
      pfam02318
      Location:8125
      FYVE_2; FYVE-type zinc finger
      pfam04698
      Location:152856
      Rab_eff_C; Rab effector MyRIP/melanophilin C-terminus
    2. XM_017595709.1XP_017451198.1  rab effector MyRIP isoform X1

      UniProtKB/TrEMBL
      D3ZTL2
      Conserved Domains (2) summary
      pfam02318
      Location:8125
      FYVE_2; FYVE-type zinc finger
      pfam04698
      Location:152856
      Rab_eff_C; Rab effector MyRIP/melanophilin C-terminus
    3. XM_017595708.1XP_017451197.1  rab effector MyRIP isoform X1

      UniProtKB/TrEMBL
      D3ZTL2
      Conserved Domains (2) summary
      pfam02318
      Location:8125
      FYVE_2; FYVE-type zinc finger
      pfam04698
      Location:152856
      Rab_eff_C; Rab effector MyRIP/melanophilin C-terminus
    4. XM_017595710.1XP_017451199.1  rab effector MyRIP isoform X1

      UniProtKB/TrEMBL
      D3ZTL2
      Conserved Domains (2) summary
      pfam02318
      Location:8125
      FYVE_2; FYVE-type zinc finger
      pfam04698
      Location:152856
      Rab_eff_C; Rab effector MyRIP/melanophilin C-terminus
    5. XM_017595711.1XP_017451200.1  rab effector MyRIP isoform X1

      UniProtKB/TrEMBL
      D3ZTL2
      Conserved Domains (2) summary
      pfam02318
      Location:8125
      FYVE_2; FYVE-type zinc finger
      pfam04698
      Location:152856
      Rab_eff_C; Rab effector MyRIP/melanophilin C-terminus
    6. XM_008766687.2XP_008764909.1  rab effector MyRIP isoform X2

      See identical proteins and their annotated locations for XP_008764909.1

      Conserved Domains (1) summary
      pfam04698
      Location:1670
      Rab_eff_C; Rab effector MyRIP/melanophilin C-terminus
    7. XM_008766686.1XP_008764908.1  rab effector MyRIP isoform X2

      See identical proteins and their annotated locations for XP_008764908.1

      Conserved Domains (1) summary
      pfam04698
      Location:1670
      Rab_eff_C; Rab effector MyRIP/melanophilin C-terminus
    8. XM_017595712.1XP_017451201.1  rab effector MyRIP isoform X2

      Conserved Domains (1) summary
      pfam04698
      Location:1670
      Rab_eff_C; Rab effector MyRIP/melanophilin C-terminus

    Alternate Rn_Celera

    Genomic

    1. AC_000076.1 Alternate Rn_Celera

      Range
      119163194..119324938
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center