Format

Send to:

Choose Destination
    • Showing Current items.

    IGL immunoglobulin lambda locus [ Homo sapiens (human) ]

    Gene ID: 3535, updated on 23-Nov-2021

    Summary

    Official Symbol
    IGLprovided by HGNC
    Official Full Name
    immunoglobulin lambda locusprovided by HGNC
    Primary source
    HGNC:HGNC:5853
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IGL@; IGLC6
    Summary
    Immunoglobulins recognize foreign antigens and initiate immune responses such as phagocytosis and the complement system. Each immunoglobulin molecule consists of two identical heavy chains and two identical light chains. There are two classes of light chains, kappa and lambda. This region represents the germline organization of the lambda light chain locus. The locus includes V (variable), J (joining), and C (constant) segments. During B cell development, a recombination event at the DNA level joins a single V segment with a J segment; the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase, and by somatic hypermutation, which occurs during B cell maturation in the spleen and lymph nodes. Several V segments and three C segments are known to be incapable of encoding a protein and are considered pseudogenes. The locus also includes several non-immunoglobulin genes, many of which are pseudogenes or are predicted by automated computational analysis or homology to other species. [provided by RefSeq, Jul 2008]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See IGL in Genome Data Viewer
    Location:
    22q11.22
    Annotation release Status Assembly Chr Location
    109.20211119 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (22026076..22922913)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (22380474..23265085)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 76 Neighboring gene PPM1F antisense RNA 1 Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent 1F Neighboring gene PRAME N-terminal like, pseudogene Neighboring gene immunoglobulin lambda variable (IV)-66-1 (pseudogene) Neighboring gene DNA topoisomerase III beta Neighboring gene uncharacterized LOC102724653 Neighboring gene immunoglobulin lambda variable 10-67 (pseudogene) Neighboring gene immunoglobulin lambda variable (I)-70 (pseudogene) Neighboring gene immunoglobulin lambda variable 4-69 Neighboring gene NAD kinase 2, mitochondrial pseudogene Neighboring gene immunoglobulin lambda variable (I)-68 (pseudogene) Neighboring gene immunoglobulin lambda variable (IV)-65 (pseudogene) Neighboring gene immunoglobulin lambda variable (IV)-64 (pseudogene) Neighboring gene immunoglobulin lambda variable (V)-66 (pseudogene) Neighboring gene immunoglobulin lambda variable (I)-63 (pseudogene) Neighboring gene immunoglobulin lambda variable 1-62 (pseudogene) Neighboring gene immunoglobulin lambda variable 8-61 Neighboring gene ABHD17A pseudogene 5 Neighboring gene OTU deubiquitinase 1 pseudogene Neighboring gene URI1, prefoldin-like chaperone pseudogene Neighboring gene immunoglobulin lambda variable 4-60 Neighboring gene immunoglobulin lambda variable (IV)-59 (pseudogene) Neighboring gene immunoglobulin lambda variable (V)-58 (pseudogene) Neighboring gene immunoglobulin lambda variable 11-55 (non-functional) Neighboring gene suppressor of cytokine signaling 2 pseudogene 2 Neighboring gene immunoglobulin lambda variable 6-57 Neighboring gene immunoglobulin lambda variable 10-54 Neighboring gene immunoglobulin lambda variable (I)-56 (pseudogene) Neighboring gene immunoglobulin lambda variable (IV)-53 (pseudogene) Neighboring gene bone morphogenetic protein 6 pseudogene 1 Neighboring gene uncharacterized LOC105372952 Neighboring gene DNA topoisomerase III beta pseudogene 1 Neighboring gene V-set pre-B cell surrogate light chain 1 Neighboring gene BMS1 pseudogene 20 Neighboring gene immunoglobulin lambda variable 5-52 Neighboring gene immunoglobulin lambda variable 1-51 Neighboring gene immunoglobulin lambda variable 1-50 (non-functional) Neighboring gene immunoglobulin lambda variable (VII)-41-1 (pseudogene) Neighboring gene uncharacterized LOC101929255 Neighboring gene immunoglobulin lambda variable 9-49 Neighboring gene immunoglobulin lambda variable 5-48 (non-functional) Neighboring gene ASH2L pseudogene 3 Neighboring gene immunoglobulin lambda variable 1-47 Neighboring gene immunoglobulin lambda variable 7-46 Neighboring gene immunoglobulin lambda variable 5-45 Neighboring gene ASH2 like, histone lysine methyltransferase complex subunit pseudogene Neighboring gene immunoglobulin lambda variable 1-44 Neighboring gene ASH2L pseudogene 2 Neighboring gene immunoglobulin lambda variable 7-43 Neighboring gene immunoglobulin lambda variable (I)-42 (pseudogene) Neighboring gene immunoglobulin lambda variable 1-41 (pseudogene) Neighboring gene immunoglobulin lambda variable 1-40 Neighboring gene immunoglobulin lambda variable (I)-38 (pseudogene) Neighboring gene immunoglobulin lambda variable 5-37 Neighboring gene immunoglobulin lambda variable 1-36 Neighboring gene uncharacterized LOC648691 Neighboring gene ASH2L pseudogene 1 Neighboring gene immunoglobulin lambda variable 7-35 (pseudogene) Neighboring gene IGL region enhancer-blocking element 22-2 Neighboring gene zinc finger protein 280B Neighboring gene zinc finger protein 280A Neighboring gene uncharacterized LL22NC03-102D1.18 Neighboring gene immunoglobulin lambda variable 2-34 (pseudogene) Neighboring gene immunoglobulin lambda variable 2-33 (non-functional) Neighboring gene immunoglobulin lambda variable 3-32 (non-functional) Neighboring gene PRAME nuclear receptor transcriptional regulator Neighboring gene immunoglobulin lambda variable 3-31 (pseudogene) Neighboring gene POM121 transmembrane nucleoporin like 1, pseudogene Neighboring gene immunoglobulin lambda variable 3-30 (pseudogene) Neighboring gene uncharacterized LOC112267890 Neighboring gene immunoglobulin lambda variable (VI)-25-1 (pseudogene) Neighboring gene gamma-glutamyltransferase-like activity 1 pseudogene Neighboring gene immunoglobulin lambda variable (VI)-22-1 (pseudogene) Neighboring gene immunoglobulin lambda variable 3-29 (pseudogene) Neighboring gene immunoglobulin lambda variable 2-28 (pseudogene) Neighboring gene immunoglobulin lambda variable 3-27 Neighboring gene immunoglobulin lambda variable 3-26 (pseudogene) Neighboring gene gamma-glutamyltransferase light chain 2 Neighboring gene BCR pseudogene 4 Neighboring gene immunoglobulin lambda variable 3-25 Neighboring gene uncharacterized LOC107985542 Neighboring gene immunoglobulin lambda variable 3-24 (pseudogene) Neighboring gene immunoglobulin lambda variable 2-23 Neighboring gene immunoglobulin lambda variable 3-22 Neighboring gene immunoglobulin lambda variable 3-21 Neighboring gene immunoglobulin lambda variable (I)-20 (pseudogene) Neighboring gene chromosome 2 open reading frame 27B pseudogene Neighboring gene immunoglobulin lambda variable 3-19 Neighboring gene uncharacterized LOC107985543 Neighboring gene immunoglobulin lambda variable 2-18 Neighboring gene immunoglobulin lambda variable 3-17 (pseudogene) Neighboring gene immunoglobulin lambda variable 3-16 Neighboring gene uncharacterized LOC105372948 Neighboring gene immunoglobulin lambda variable 3-15 (pseudogene) Neighboring gene immunoglobulin lambda variable 2-14 Neighboring gene immunoglobulin lambda variable 3-13 (pseudogene) Neighboring gene immunoglobulin lambda variable 3-12 Neighboring gene immunoglobulin lambda variable 2-11 Neighboring gene uncharacterized LOC102724638 Neighboring gene immunoglobulin lambda variable 3-10 Neighboring gene immunoglobulin lambda variable 3-9 Neighboring gene immunoglobulin lambda variable 2-8 Neighboring gene uncharacterized LOC105372947 Neighboring gene immunoglobulin lambda variable 3-7 (pseudogene) Neighboring gene microRNA 650 Neighboring gene immunoglobulin lambda variable 3-6 (pseudogene) Neighboring gene immunoglobulin lambda variable 2-5 (pseudogene) Neighboring gene immunoglobulin lambda variable 3-4 (pseudogene) Neighboring gene immunoglobulin lambda variable 4-3 Neighboring gene immunoglobulin lambda variable 3-2 (pseudogene) Neighboring gene immunoglobulin lambda variable 3-1 Neighboring gene microRNA 5571 Neighboring gene ATP synthase-coupling factor 6, mitochondrial-like Neighboring gene immunoglobulin lambda like polypeptide 5 Neighboring gene immunoglobulin lambda joining 1 Neighboring gene immunoglobulin lambda constant 1 Neighboring gene immunoglobulin lambda joining 2 Neighboring gene immunoglobulin lambda constant 2 Neighboring gene immunoglobulin lambda constant 3 (Kern-Oz+ marker) Neighboring gene immunoglobulin lambda joining 3 Neighboring gene immunoglobulin lambda joining 4 (non-functional) Neighboring gene immunoglobulin lambda constant 4 (pseudogene) Neighboring gene immunoglobulin lambda joining 5 (non-functional) Neighboring gene immunoglobulin lambda constant 5 (pseudogene) Neighboring gene immunoglobulin lambda joining 6 Neighboring gene immunoglobulin lambda constant 6 Neighboring gene immunoglobulin lambda joining 7 Neighboring gene immunoglobulin lambda constant 7 Neighboring gene radial spoke head 14 homolog Neighboring gene G protein subunit alpha z

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Genome-wide association study identifies genetic loci associated with iron deficiency.
    GeneReviews: Not available
    Genome-wide association study of chronic periodontitis in a general German population.
    GeneReviews: Not available

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Other Names

    • immunoglobulin lambda gene cluster

    Clone Names

    • MGC88804

    General protein information

    Preferred Names
    ig lambda-6 chain C region
    Names
    immunoglobulin lambda gene cluster

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_000002.1 

      Range
      4463..889069
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

      Range
      22026076..22922913
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center