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    IGFBP5 insulin like growth factor binding protein 5 [ Homo sapiens (human) ]

    Gene ID: 3488, updated on 6-Sep-2021

    Summary

    Official Symbol
    IGFBP5provided by HGNC
    Official Full Name
    insulin like growth factor binding protein 5provided by HGNC
    Primary source
    HGNC:HGNC:5474
    See related
    Ensembl:ENSG00000115461 MIM:146734
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IBP5
    Expression
    Broad expression in ovary (RPKM 758.5), endometrium (RPKM 331.1) and 14 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See IGFBP5 in Genome Data Viewer
    Location:
    2q35
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (216672105..216695549, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (217536828..217560272, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene proteasome subunit beta 3 pseudogene 2 Neighboring gene insulin like growth factor binding protein 2 Neighboring gene IGFBP5 antisense RNA 1 Neighboring gene ribosomal protein L31 pseudogene 14 Neighboring gene RNA, 5S ribosomal pseudogene 120

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function.
    GeneReviews: Not available
    Genetic Variants Associated with Serum Thyroid Stimulating Hormone (TSH) Levels in European Americans and African Americans from the eMERGE Network.
    GeneReviews: Not available
    Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
    GeneReviews: Not available

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables fibronectin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables insulin-like growth factor I binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables insulin-like growth factor I binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables insulin-like growth factor II binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in aging IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to cAMP IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to organic cyclic compound IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in female pregnancy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in glucose homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in hair follicle morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lung alveolus development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mammary gland involution IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of growth IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of insulin-like growth factor receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of muscle tissue development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of osteoblast differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of skeletal muscle hypertrophy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of smooth muscle cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of smooth muscle cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of translation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in osteoblast differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of insulin-like growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein kinase B signaling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of vascular associated smooth muscle cell migration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of vascular associated smooth muscle cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of cell growth IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of insulin-like growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in response to growth hormone ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in signal transduction NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in striated muscle cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in type B pancreatic cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in endoplasmic reticulum lumen TAS
    Traceable Author Statement
    more info
     
    located_in extracellular region NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of insulin-like growth factor binding protein complex IC
    Inferred by Curator
    more info
    PubMed 
    part_of insulin-like growth factor ternary complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    insulin-like growth factor-binding protein 5
    Names
    IBP-5
    IGF-binding protein 5
    IGFBP-5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_000599.4NP_000590.1  insulin-like growth factor-binding protein 5 precursor

      See identical proteins and their annotated locations for NP_000590.1

      Status: VALIDATED

      Source sequence(s)
      AC007563
      Consensus CDS
      CCDS2405.1
      UniProtKB/Swiss-Prot
      P24593
      UniProtKB/TrEMBL
      A0A024R433
      Related
      ENSP00000233813.4, ENST00000233813.5
      Conserved Domains (2) summary
      smart00121
      Location:25101
      IB; Insulin growth factor-binding protein homologues
      pfam00086
      Location:192263
      Thyroglobulin_1; Thyroglobulin type-1 repeat

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

      Range
      216672105..216695549 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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