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    NME9 NME/NM23 family member 9 [ Homo sapiens (human) ]

    Gene ID: 347736, updated on 2-Oct-2018

    Summary

    Official Symbol
    NME9provided by HGNC
    Official Full Name
    NME/NM23 family member 9provided by HGNC
    Primary source
    HGNC:HGNC:21343
    See related
    Ensembl:ENSG00000181322 Vega:OTTHUMG00000159823
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TXL2; TXL-2; TXNDC6; NM23-H9
    Expression
    Ubiquitous expression in thyroid (RPKM 1.1), brain (RPKM 1.0) and 25 other tissues See more
    Orthologs

    Genomic context

    See NME9 in Genome Data Viewer
    Location:
    3q22.3
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 3 NC_000003.12 (138261437..138331785, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (137980279..138049018, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene alpha-1,4-N-acetylglucosaminyltransferase Neighboring gene debranching RNA lariats 1 Neighboring gene armadillo repeat containing 8 Neighboring gene muscle RAS oncogene homolog Neighboring gene uncharacterized LOC105374129

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease.
    NHGRI GWA Catalog

    General gene information

    Markers

    Homology

    Clone Names

    • MGC129586

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    nucleoside diphosphate kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    CTP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    GTP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    UTP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    cell redox homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoside diphosphate phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    thioredoxin domain-containing protein 6
    Names
    NME gene family member 9
    thioredoxin-like protein 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001349018.1NP_001335947.1  thioredoxin domain-containing protein 6 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AC022337
      Consensus CDS
      CCDS87142.1
      Related
      ENSP00000335444.3, ENST00000333911.7
      Conserved Domains (2) summary
      cd02948
      Location:11112
      TRX_NDPK; TRX domain, TRX and NDP-kinase (NDPK) fusion protein family; most members of this group are fusion proteins which contain one redox active TRX domain containing a CXXC motif and three NDPK domains, and are characterized as intermediate chains (ICs) of ...
      cd04416
      Location:159295
      NDPk_TX; NDP kinase domain of thioredoxin domain-containing proteins (TXNDC3 and TXNDC6): Txl-2 (TXNDC6) and Sptrx-2 (TXNDC3) are fusion proteins of Group II N-terminal thioredoxin domains followed by one or three NDP kinase domains, respectively. Sptrx-2, which ...
    2. NM_001349020.1NP_001335949.1  thioredoxin domain-containing protein 6 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AC022337
      Conserved Domains (2) summary
      cd04416
      Location:96232
      NDPk_TX; NDP kinase domain of thioredoxin domain-containing proteins (TXNDC3 and TXNDC6): Txl-2 (TXNDC6) and Sptrx-2 (TXNDC3) are fusion proteins of Group II N-terminal thioredoxin domains followed by one or three NDP kinase domains, respectively. Sptrx-2, which ...
      cl00388
      Location:1173
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
    3. NM_001349021.1NP_001335950.1  thioredoxin domain-containing protein 6 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 3' UTR and coding sequence and lacks two alternate in-frame exons compared to variant 1. The resulting isoform (d) has a shorter and distinct C-terminus and lacks an alternate internal segment compared to isoform a.
      Source sequence(s)
      AC022337, AC068777
      Consensus CDS
      CCDS87141.1
      Related
      ENSP00000419882.1, ENST00000484930.5
      Conserved Domains (2) summary
      cd04416
      Location:96232
      NDPk_TX; NDP kinase domain of thioredoxin domain-containing proteins (TXNDC3 and TXNDC6): Txl-2 (TXNDC6) and Sptrx-2 (TXNDC3) are fusion proteins of Group II N-terminal thioredoxin domains followed by one or three NDP kinase domains, respectively. Sptrx-2, which ...
      cl00388
      Location:1173
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
    4. NM_001349022.1NP_001335951.1  thioredoxin domain-containing protein 6 isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (e) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform a.
      Source sequence(s)
      AC022337
      Conserved Domains (2) summary
      cd04416
      Location:98234
      NDPk_TX; NDP kinase domain of thioredoxin domain-containing proteins (TXNDC3 and TXNDC6): Txl-2 (TXNDC6) and Sptrx-2 (TXNDC3) are fusion proteins of Group II N-terminal thioredoxin domains followed by one or three NDP kinase domains, respectively. Sptrx-2, which ...
      cl00388
      Location:167
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
    5. NM_001349023.1NP_001335952.1  thioredoxin domain-containing protein 6 isoform f

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (f) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform a.
      Source sequence(s)
      AC022337
      Conserved Domains (2) summary
      cd04416
      Location:69205
      NDPk_TX; NDP kinase domain of thioredoxin domain-containing proteins (TXNDC3 and TXNDC6): Txl-2 (TXNDC6) and Sptrx-2 (TXNDC3) are fusion proteins of Group II N-terminal thioredoxin domains followed by one or three NDP kinase domains, respectively. Sptrx-2, which ...
      cl00388
      Location:138
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
    6. NM_001349024.1NP_001335953.1  thioredoxin domain-containing protein 6 isoform g

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (g) has the same N- and C-termini but is shorter compared to isoform a. Variants 7 and 8 both encode the same isoform (g).
      Source sequence(s)
      AC022337
      Conserved Domains (2) summary
      cd02948
      Location:1189
      TRX_NDPK; TRX domain, TRX and NDP-kinase (NDPK) fusion protein family; most members of this group are fusion proteins which contain one redox active TRX domain containing a CXXC motif and three NDPK domains, and are characterized as intermediate chains (ICs) of ...
      cd04416
      Location:120256
      NDPk_TX; NDP kinase domain of thioredoxin domain-containing proteins (TXNDC3 and TXNDC6): Txl-2 (TXNDC6) and Sptrx-2 (TXNDC3) are fusion proteins of Group II N-terminal thioredoxin domains followed by one or three NDP kinase domains, respectively. Sptrx-2, which ...
    7. NM_001349025.1NP_001335954.1  thioredoxin domain-containing protein 6 isoform g

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (g) has the same N- and C-termini but is shorter compared to isoform a. Variants 7 and 8 both encode the same isoform (g).
      Source sequence(s)
      AC022337
      Conserved Domains (2) summary
      cd02948
      Location:1189
      TRX_NDPK; TRX domain, TRX and NDP-kinase (NDPK) fusion protein family; most members of this group are fusion proteins which contain one redox active TRX domain containing a CXXC motif and three NDPK domains, and are characterized as intermediate chains (ICs) of ...
      cd04416
      Location:120256
      NDPk_TX; NDP kinase domain of thioredoxin domain-containing proteins (TXNDC3 and TXNDC6): Txl-2 (TXNDC6) and Sptrx-2 (TXNDC3) are fusion proteins of Group II N-terminal thioredoxin domains followed by one or three NDP kinase domains, respectively. Sptrx-2, which ...
    8. NM_178130.3NP_835231.1  thioredoxin domain-containing protein 6 isoform b

      See identical proteins and their annotated locations for NP_835231.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence, the 3' UTR and coding sequence, and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) is shorter at the N-terminus, has a shorter and distinct C-terminus, and lacks an alternate internal segment compared to isoform a.
      Source sequence(s)
      AC022337, AK094830
      Consensus CDS
      CCDS3099.1
      UniProtKB/Swiss-Prot
      Q86XW9
      Related
      ENSP00000372667.2, OTTHUMP00000216650, ENST00000383180.6, OTTHUMT00000357581
      Conserved Domains (2) summary
      cd04416
      Location:98234
      NDPk_TX; NDP kinase domain of thioredoxin domain-containing proteins (TXNDC3 and TXNDC6): Txl-2 (TXNDC6) and Sptrx-2 (TXNDC3) are fusion proteins of Group II N-terminal thioredoxin domains followed by one or three NDP kinase domains, respectively. Sptrx-2, which ...
      cl00388
      Location:167
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p12 Primary Assembly

      Range
      138261437..138331785 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017006316.2XP_016861805.1  thioredoxin domain-containing protein 6 isoform X10

      Related
      OTTHUMP00000216653
    2. XM_017006312.2XP_016861801.1  thioredoxin domain-containing protein 6 isoform X7

    3. XM_017006308.2XP_016861797.1  thioredoxin domain-containing protein 6 isoform X3

    4. XM_017006313.2XP_016861802.1  thioredoxin domain-containing protein 6 isoform X8

    5. XM_011512777.3XP_011511079.1  thioredoxin domain-containing protein 6 isoform X12

      Related
      ENSP00000419355.1, OTTHUMP00000216651, ENST00000492993.5
      Conserved Domains (2) summary
      cd02948
      Location:23101
      TRX_NDPK; TRX domain, TRX and NDP-kinase (NDPK) fusion protein family; most members of this group are fusion proteins which contain one redox active TRX domain containing a CXXC motif and three NDPK domains, and are characterized as intermediate chains (ICs) of ...
      cl00335
      Location:132185
      NDPk; Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are ...
    6. XM_011512774.3XP_011511076.1  thioredoxin domain-containing protein 6 isoform X6

      Conserved Domains (3) summary
      smart00562
      Location:133273
      NDK; Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates
      cd02948
      Location:23101
      TRX_NDPK; TRX domain, TRX and NDP-kinase (NDPK) fusion protein family; most members of this group are fusion proteins which contain one redox active TRX domain containing a CXXC motif and three NDPK domains, and are characterized as intermediate chains (ICs) of ...
      cd04416
      Location:132268
      NDPk_TX; NDP kinase domain of thioredoxin domain-containing proteins (TXNDC3 and TXNDC6): Txl-2 (TXNDC6) and Sptrx-2 (TXNDC3) are fusion proteins of Group II N-terminal thioredoxin domains followed by one or three NDP kinase domains, respectively. Sptrx-2, which ...
    7. XM_017006311.2XP_016861800.1  thioredoxin domain-containing protein 6 isoform X5

    8. XM_017006306.2XP_016861795.1  thioredoxin domain-containing protein 6 isoform X1

    9. XM_005247429.4XP_005247486.1  thioredoxin domain-containing protein 6 isoform X2

      Related
      OTTHUMP00000216652
      Conserved Domains (3) summary
      smart00562
      Location:172312
      NDK; Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates
      cd02948
      Location:23124
      TRX_NDPK; TRX domain, TRX and NDP-kinase (NDPK) fusion protein family; most members of this group are fusion proteins which contain one redox active TRX domain containing a CXXC motif and three NDPK domains, and are characterized as intermediate chains (ICs) of ...
      cd04416
      Location:171307
      NDPk_TX; NDP kinase domain of thioredoxin domain-containing proteins (TXNDC3 and TXNDC6): Txl-2 (TXNDC6) and Sptrx-2 (TXNDC3) are fusion proteins of Group II N-terminal thioredoxin domains followed by one or three NDP kinase domains, respectively. Sptrx-2, which ...
    10. XM_017006309.2XP_016861798.1  thioredoxin domain-containing protein 6 isoform X4

    11. XM_017006317.2XP_016861806.1  thioredoxin domain-containing protein 6 isoform X11

      Conserved Domains (2) summary
      cd04416
      Location:98234
      NDPk_TX; NDP kinase domain of thioredoxin domain-containing proteins (TXNDC3 and TXNDC6): Txl-2 (TXNDC6) and Sptrx-2 (TXNDC3) are fusion proteins of Group II N-terminal thioredoxin domains followed by one or three NDP kinase domains, respectively. Sptrx-2, which ...
      cl00388
      Location:167
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
    12. XM_017006315.2XP_016861804.1  thioredoxin domain-containing protein 6 isoform X9

    13. XM_017006310.2XP_016861799.1  thioredoxin domain-containing protein 6 isoform X4

    14. XM_017006314.2XP_016861803.1  thioredoxin domain-containing protein 6 isoform X8

    15. XM_017006319.2XP_016861808.1  thioredoxin domain-containing protein 6 isoform X13

    RNA

    1. XR_001740139.1 RNA Sequence

    2. XR_924132.2 RNA Sequence

    3. XR_924130.3 RNA Sequence

    4. XR_924131.2 RNA Sequence

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