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    Nos Nitric oxide synthase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34495, updated on 9-May-2019

    Summary

    Official Symbol
    Nosprovided by FlyBase
    Official Full Name
    Nitric oxide synthaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0011676
    Locus tag
    Dmel_CG6713
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6713; Dmel\CG6713; dNos; dNOS; DNOS; DNOS1; drNOSoxy; iNOS; nNOS; nos; NOS

    Genomic context

    See Nos in Genome Data Viewer
    Location:
    32B1-32B1; 2-43 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    Release 6.26 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10804274..10837511, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10804274..10837511, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44581 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene mir-4987 stem loop Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    • Homologs of the Nos gene: The Nos gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, mosquito, and frog.

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    FMN binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    NADP binding IEA
    Inferred from Electronic Annotation
    more info
     
    NADPH-hemoprotein reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    calmodulin binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    flavin adenine dinucleotide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    heme binding IEA
    Inferred from Electronic Annotation
    more info
     
    heme binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    nitric-oxide synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nitric-oxide synthase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nitric-oxide synthase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nitric-oxide synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    nitric-oxide synthase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    arginine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    imaginal disc development TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of DNA replication TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of cell proliferation TAS
    Traceable Author Statement
    more info
    PubMed 
    nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nitric oxide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nitric oxide biosynthetic process TAS
    Traceable Author Statement
    more info
    PubMed 
    nitric oxide mediated signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of guanylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of heart rate IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of organ growth TAS
    Traceable Author Statement
    more info
    PubMed 
    response to hormone IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    response to lipopolysaccharide IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    synapse assembly TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    peroxisome ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    nitric oxide synthase
    Names
    CG6713-PA
    CG6713-PF
    CG6713-PK
    NO synthase
    Nos-PA
    Nos-PF
    Nos-PK
    nitric oixide synthase
    nitric oxidesynthase
    NP_001027240.1
    NP_001027243.2
    NP_523541.2

    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      10804274..10837511 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078817.4NP_523541.2  nitric oxide synthase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523541.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q27571
      Related
      FBpp0079777, FBtr0080188
      Conserved Domains (4) summary
      cd06202
      Location:9311328
      Nitric_oxide_synthase; The ferredoxin-reductase (FNR) like C-terminal domain of the nitric oxide synthase (NOS) fuses with a heme-containing N-terminal oxidase domain. The reductase portion is similar in structure to NADPH dependent cytochrome-450 reductase (CYPOR), having an ...
      COG0369
      Location:6691323
      CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
      cd00795
      Location:216624
      NOS_oxygenase_euk; Nitric oxide synthase (NOS) eukaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N ...
      pfam00258
      Location:673863
      Flavodoxin_1; Flavodoxin
    2. NM_001032069.2NP_001027240.1  nitric oxide synthase, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001027240.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q27571
      Related
      FBpp0099926, FBtr0100489
      Conserved Domains (2) summary
      cd00795
      Location:216624
      NOS_oxygenase_euk; Nitric oxide synthase (NOS) eukaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N ...
      pfam00258
      Location:673735
      Flavodoxin_1; Flavodoxin
    3. NM_001032072.2NP_001027243.2  nitric oxide synthase, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001027243.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q27571
      Related
      FBpp0310415, FBtr0343888
      Conserved Domains (4) summary
      cd06202
      Location:6801077
      Nitric_oxide_synthase; The ferredoxin-reductase (FNR) like C-terminal domain of the nitric oxide synthase (NOS) fuses with a heme-containing N-terminal oxidase domain. The reductase portion is similar in structure to NADPH dependent cytochrome-450 reductase (CYPOR), having an ...
      COG0369
      Location:4181072
      CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
      cd00795
      Location:3373
      NOS_oxygenase_euk; Nitric oxide synthase (NOS) eukaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N ...
      pfam00258
      Location:422612
      Flavodoxin_1; Flavodoxin
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