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    AADACL4 arylacetamide deacetylase like 4 [ Homo sapiens (human) ]

    Gene ID: 343066, updated on 13-Feb-2019

    Summary

    Official Symbol
    AADACL4provided by HGNC
    Official Full Name
    arylacetamide deacetylase like 4provided by HGNC
    Primary source
    HGNC:HGNC:32038
    See related
    Ensembl:ENSG00000204518
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Low expression observed in reference dataset See more
    Orthologs

    Genomic context

    See AADACL4 in Genome Data Viewer
    Location:
    1p36.21
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (12644547..12667086)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (12704566..12727097)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RNA, U6atac small nuclear 18, pseudogene Neighboring gene dehydrogenase/reductase 3 Neighboring gene microRNA 6730 Neighboring gene arylacetamide deacetylase like 3 Neighboring gene chromosome 1 open reading frame 158

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    NHGRI GWA Catalog

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    carboxylic ester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    arylacetamide deacetylase-like 4

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013630.1NP_001013652.1  arylacetamide deacetylase-like 4

      See identical proteins and their annotated locations for NP_001013652.1

      Status: VALIDATED

      Source sequence(s)
      AC254633
      Consensus CDS
      CCDS30590.1
      UniProtKB/Swiss-Prot
      Q5VUY2
      Related
      ENSP00000365395.1, ENST00000376221.1
      Conserved Domains (2) summary
      COG0657
      Location:85378
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
      cl21494
      Location:115378
      Abhydrolase; alpha/beta hydrolases

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

      Range
      12644547..12667086
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017001152.1XP_016856641.1  arylacetamide deacetylase-like 4 isoform X1

    2. XM_017001153.1XP_016856642.1  arylacetamide deacetylase-like 4 isoform X2

      Conserved Domains (2) summary
      COG0657
      Location:3212
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
      cl21494
      Location:14212
      Abhydrolase; alpha/beta hydrolases
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