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    LIPM lipase family member M [ Homo sapiens (human) ]

    Gene ID: 340654, updated on 23-May-2018

    Summary

    Official Symbol
    LIPMprovided by HGNC
    Official Full Name
    lipase family member Mprovided by HGNC
    Primary source
    HGNC:HGNC:23455
    See related
    Ensembl:ENSG00000173239 MIM:613923; Vega:OTTHUMG00000018698
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LIPL3; bA304I5.1
    Expression
    Biased expression in skin (RPKM 5.3), stomach (RPKM 0.7) and 2 other tissues See more
    Orthologs

    Genomic context

    See LIPM in Genome Data Viewer
    Location:
    10q23.31
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 10 NC_000010.11 (88802730..88822022)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (90562487..90580315)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene lipase family member N Neighboring gene RCC1 and BTB domain containing protein 2 pseudogene 1 Neighboring gene ankyrin repeat domain 22 Neighboring gene pentatricopeptide repeat domain 2 pseudogene 2 Neighboring gene STAM binding protein like 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Pathways from BioSystems

    • Digestion of dietary lipid, organism-specific biosystem (from REACTOME)
      Digestion of dietary lipid, organism-specific biosystemDietary lipids such as long-chain triacylglycerols and cholesterol esters are digested in the stomach and small intestine to yield long-chain fatty acids, monoacylglycerols, glycerol and cholesterol ...
    • Lipid digestion, mobilization, and transport, organism-specific biosystem (from REACTOME)
      Lipid digestion, mobilization, and transport, organism-specific biosystemProcesses annotated here include the digestion of dietary lipids, sterol uptake, the formation and turnover of lipoproteins (chylomicrons, VLDL, LDL, and HDL), and the mobilization of fatty acids thr...
    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
    • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
      Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    lipase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    lipoprotein lipase activity TAS
    Traceable Author Statement
    more info
     
    Process Evidence Code Pubs
    cellular lipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cornification TAS
    Traceable Author Statement
    more info
     
    lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    extracellular region TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    lipase member M
    Names
    lipase M
    lipase-like abhydrolase domain-containing protein 3
    lipase-like, ab-hydrolase domain containing 3

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001128215.1NP_001121687.1  lipase member M precursor

      See identical proteins and their annotated locations for NP_001121687.1

      Status: VALIDATED

      Source sequence(s)
      AL358532, BC157888, EF426484
      Consensus CDS
      CCDS44457.1
      UniProtKB/Swiss-Prot
      Q5VYY2
      Related
      ENSP00000383901.3, OTTHUMP00000020040, ENST00000404743.8, OTTHUMT00000049261
      Conserved Domains (3) summary
      pfam00561
      Location:92392
      Abhydrolase_1; alpha/beta hydrolase fold
      pfam04083
      Location:49111
      Abhydro_lipase; Partial alpha/beta-hydrolase lipase region
      pfam12695
      Location:93231
      Abhydrolase_5; Alpha/beta hydrolase family

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p12 Primary Assembly

      Range
      88802730..88822022
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011539748.3XP_011538050.1  lipase member M isoform X1

      See identical proteins and their annotated locations for XP_011538050.1

      Conserved Domains (3) summary
      pfam00561
      Location:92399
      Abhydrolase_1; alpha/beta hydrolase fold
      pfam04083
      Location:49111
      Abhydro_lipase; Partial alpha/beta-hydrolase lipase region
      pfam12695
      Location:93231
      Abhydrolase_5; Alpha/beta hydrolase family
    2. XM_011539753.2XP_011538055.1  lipase member M isoform X4

      Conserved Domains (2) summary
      pfam04083
      Location:49111
      Abhydro_lipase; Partial alpha/beta-hydrolase lipase region
      pfam12695
      Location:93231
      Abhydrolase_5; Alpha/beta hydrolase family
    3. XM_011539751.3XP_011538053.1  lipase member M isoform X2

      Conserved Domains (1) summary
      PLN02872
      Location:1283
      PLN02872; triacylglycerol lipase
    4. XM_011539752.3XP_011538054.1  lipase member M isoform X3

      Conserved Domains (1) summary
      PLN02872
      Location:1221
      PLN02872; triacylglycerol lipase
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