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    AGBL3 ATP/GTP binding protein like 3 [ Homo sapiens (human) ]

    Gene ID: 340351, updated on 15-Jun-2019

    Summary

    Official Symbol
    AGBL3provided by HGNC
    Official Full Name
    ATP/GTP binding protein like 3provided by HGNC
    Primary source
    HGNC:HGNC:27981
    See related
    Ensembl:ENSG00000146856 MIM:617346
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CCP3
    Expression
    Broad expression in testis (RPKM 2.0), endometrium (RPKM 0.4) and 16 other tissues See more
    Orthologs

    Genomic context

    See AGBL3 in Genome Data Viewer
    Location:
    7q33
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 7 NC_000007.14 (134986139..135135782)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (134671259..134820530)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986850 Neighboring gene caldesmon 1 Neighboring gene ring finger protein 14 pseudogene Neighboring gene cell cycle regulator of NHEJ Neighboring gene transmembrane protein 140 Neighboring gene WD repeat domain 91 Neighboring gene microRNA 6509

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.
    NHGRI GWA Catalog

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ12983, MGC32955

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    metallocarboxypeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    protein side chain deglutamylation IEA
    Inferred from Electronic Annotation
    more info
     
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytosol IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    cytosolic carboxypeptidase 3

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001345850.1NP_001332779.1  cytosolic carboxypeptidase 3 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC083862, AC083870, AC090497
      Conserved Domains (1) summary
      cl11393
      Location:271
      Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins
    2. NM_001345851.1NP_001332780.1  cytosolic carboxypeptidase 3 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC083862, AC083870, AC090497
    3. NM_001345852.1NP_001332781.1  cytosolic carboxypeptidase 3 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) encodes isoform d. Variants 4 and 5 both encode the same isoform (d).
      Source sequence(s)
      AC083862, AC083870, AC090497
      Conserved Domains (1) summary
      cl11393
      Location:271
      Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins
    4. NM_001345853.1NP_001332782.1  cytosolic carboxypeptidase 3 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) encodes isoform d. Variants 4 and 5 both encode the same isoform (d).
      Source sequence(s)
      AC083862, AC083870, AC090497
      Conserved Domains (1) summary
      cl11393
      Location:271
      Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins
    5. NM_001367811.1NP_001354740.1  cytosolic carboxypeptidase 3 isoform e

      Status: VALIDATED

      Source sequence(s)
      AC083870, AC090497
    6. NM_001367812.1NP_001354741.1  cytosolic carboxypeptidase 3 isoform f

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8), as well as variant 9, encodes isoform f.
      Source sequence(s)
      AC083870, AC090497
    7. NM_001367813.1NP_001354742.1  cytosolic carboxypeptidase 3 isoform f

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9), as well as variant 8, encodes isoform f.
      Source sequence(s)
      AC083870, AC090497
    8. NM_001367814.1NP_001354743.1  cytosolic carboxypeptidase 3 isoform g

      Status: VALIDATED

      Source sequence(s)
      AC083862, AC083870, AC090497
    9. NM_001367815.1NP_001354744.1  cytosolic carboxypeptidase 3 isoform h

      Status: VALIDATED

      Source sequence(s)
      AC083870, AC090497
    10. NM_001367816.1NP_001354745.1  cytosolic carboxypeptidase 3 isoform i

      Status: VALIDATED

      Description
      Transcript Variant: This variant (12), as well as variants 13 and 14, encodes isoform i.
      Source sequence(s)
      AC083870, AC090497
    11. NM_001367817.1NP_001354746.1  cytosolic carboxypeptidase 3 isoform i

      Status: VALIDATED

      Description
      Transcript Variant: This variant (13), as well as variants 12 and 14, encodes isoform i.
      Source sequence(s)
      AC083870, AC090497
    12. NM_001367818.1NP_001354747.1  cytosolic carboxypeptidase 3 isoform i

      Status: VALIDATED

      Description
      Transcript Variant: This variant (14), as well as variants 12 and 13, encodes isoform i.
      Source sequence(s)
      AC083870, AC090497
    13. NM_001367819.1NP_001354748.1  cytosolic carboxypeptidase 3 isoform j precursor

      Status: VALIDATED

      Source sequence(s)
      AC083870, AC090497
    14. NM_178563.4NP_848658.3  cytosolic carboxypeptidase 3 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AA707617, AC083862, AC090497, AK302827
      Consensus CDS
      CCDS47718.1
      UniProtKB/Swiss-Prot
      Q8NEM8
      Related
      ENSP00000388275.2, ENST00000436302.6
      Conserved Domains (1) summary
      cd06907
      Location:310570
      M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins

    RNA

    1. NR_144293.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC083862, AC083870, AC090497
    2. NR_160297.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC083870, AC090497
    3. NR_160298.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC083870, AC090497
    4. NR_160299.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC083870
    5. NR_160300.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC083862, AC083870, AC090497

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

      Range
      134986139..135135782
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017012137.2XP_016867626.1  cytosolic carboxypeptidase 3 isoform X1

      UniProtKB/Swiss-Prot
      Q8NEM8
      Conserved Domains (1) summary
      cd06907
      Location:310570
      M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
    2. XM_017012140.2XP_016867629.1  cytosolic carboxypeptidase 3 isoform X4

    3. XM_017012142.2XP_016867631.1  cytosolic carboxypeptidase 3 isoform X6

    4. XM_017012143.2XP_016867632.1  cytosolic carboxypeptidase 3 isoform X7

      Related
      ENSP00000401220.2, ENST00000435976.6
    5. XM_017012138.2XP_016867627.1  cytosolic carboxypeptidase 3 isoform X2

    6. XM_017012139.2XP_016867628.1  cytosolic carboxypeptidase 3 isoform X3

    7. XM_024446749.1XP_024302517.1  cytosolic carboxypeptidase 3 isoform X9

      Conserved Domains (1) summary
      cl11393
      Location:271
      Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins
    8. XM_024446750.1XP_024302518.1  cytosolic carboxypeptidase 3 isoform X10

      Conserved Domains (1) summary
      cl11393
      Location:271
      Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins
    9. XM_011516122.3XP_011514424.1  cytosolic carboxypeptidase 3 isoform X8

      Conserved Domains (1) summary
      cl11393
      Location:310502
      Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins
    10. XM_017012136.2XP_016867625.1  cytosolic carboxypeptidase 3 isoform X1

      UniProtKB/Swiss-Prot
      Q8NEM8
      Conserved Domains (1) summary
      cd06907
      Location:310570
      M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
    11. XM_017012141.2XP_016867630.1  cytosolic carboxypeptidase 3 isoform X5

    RNA

    1. XR_001744699.2 RNA Sequence

    2. XR_001744696.2 RNA Sequence

    3. XR_001744698.2 RNA Sequence

    4. XR_001744697.2 RNA Sequence

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