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    KCNK18 potassium two pore domain channel subfamily K member 18 [ Homo sapiens (human) ]

    Gene ID: 338567, updated on 19-May-2018
    Official Symbol
    KCNK18provided by HGNC
    Official Full Name
    potassium two pore domain channel subfamily K member 18provided by HGNC
    Primary source
    HGNC:HGNC:19439
    See related
    Ensembl:ENSG00000186795 MIM:613655; Vega:OTTHUMG00000019120
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TRIK; MGR13; TRESK; TRESK2; K2p18.1; TRESK-2
    Summary
    Potassium channels play a role in many cellular processes including maintenance of the action potential, muscle contraction, hormone secretion, osmotic regulation, and ion flow. This gene encodes a member of the superfamily of potassium channel proteins containing two pore-forming P domains and the encoded protein functions as an outward rectifying potassium channel. A mutation in this gene has been found to be associated with migraine with aura.[provided by RefSeq, Jan 2011]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    See KCNK18 in Genome Data Viewer
    Location:
    10q25.3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 10 NC_000010.11 (117197489..117210299)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (118957000..118969810)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene MIR3663 host gene Neighboring gene microRNA 3663 Neighboring gene ribosomal protein L12 pseudogene 26 Neighboring gene uncharacterized LOC105378500 Neighboring gene solute carrier family 18 member A2 Neighboring gene PDZ domain containing 8

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Cardiac conduction, organism-specific biosystem (from REACTOME)
      Cardiac conduction, organism-specific biosystemThe normal sequence of contraction of atria and ventricles of the heart require activation of groups of cardiac cells. The mechanism must elicit rapid changes in heart rate and respond to changes in ...
    • Muscle contraction, organism-specific biosystem (from REACTOME)
      Muscle contraction, organism-specific biosystemIn this module, the processes by which calcium binding triggers actin - myosin interactions and force generation in smooth and striated muscle tissues are annotated.
    • Neuronal System, organism-specific biosystem (from REACTOME)
      Neuronal System, organism-specific biosystemThe human brain contains at least 100 billion neurons, each with the ability to influence many other cells. Clearly, highly sophisticated and efficient mechanisms are needed to enable communication a...
    • Phase 4 - resting membrane potential, organism-specific biosystem (from REACTOME)
      Phase 4 - resting membrane potential, organism-specific biosystemPhase 4 describes the membrane potential when a cell is not being stimulated. The normal resting potential in the ventricular myocardium is between -85 to -95 mV. The membrane is most permeable to K+...
    • Potassium Channels, organism-specific biosystem (from REACTOME)
      Potassium Channels, organism-specific biosystemPotassium channels are tetrameric ion channels that are widely distributed and are found in all cell types. Potassium channels control resting membrane potential in neurons, contribute to regulation ...
    • TWIK-related spinal cord K+ channel (TRESK), organism-specific biosystem (from REACTOME)
      TWIK-related spinal cord K+ channel (TRESK), organism-specific biosystemTRESK subfamily of tandem domain K+ channels has one only member. TRESK is regulated by Ca/calmodulin dependent protein phosphatase, calcineurin.
    • Tandem pore domain potassium channels, organism-specific biosystem (from REACTOME)
      Tandem pore domain potassium channels, organism-specific biosystemTandem pore domain K+ channels (K2p) produce leak K+ current which stabilizes negative membrane potential and counter balances depolarization. These channels are regulated by voltage independent mech...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    calcium-activated potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    outward rectifier potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    outward rectifier potassium channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    potassium channel activity TAS
    Traceable Author Statement
    more info
     
    potassium ion leak channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    cellular response to pH IDA
    Inferred from Direct Assay
    more info
    PubMed 
    potassium ion export IDA
    Inferred from Direct Assay
    more info
    PubMed 
    potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    potassium ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    stabilization of membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    integral component of plasma membrane IC
    Inferred by Curator
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    potassium channel subfamily K member 18
    Names
    TWIK-related individual K+ channel
    TWIK-related individual potassium channel
    TWIK-related spinal cord K+ channel
    TWIK-related spinal cord potassium channel
    potassium channel, subfamily K, member 18
    potassium channel, two pore domain subfamily K, member 18

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_028085.1 RefSeqGene

      Range
      5001..17811
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_181840.1NP_862823.1  potassium channel subfamily K member 18

      See identical proteins and their annotated locations for NP_862823.1

      Status: REVIEWED

      Source sequence(s)
      AB087138
      Consensus CDS
      CCDS7598.1
      UniProtKB/Swiss-Prot
      Q7Z418
      Related
      ENSP00000334650.1, OTTHUMP00000020575, ENST00000334549.1, OTTHUMT00000050562
      Conserved Domains (1) summary
      pfam07885
      Location:100155
      Ion_trans_2; Ion channel

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p12 Primary Assembly

      Range
      117197489..117210299
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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