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    ICAM1 intercellular adhesion molecule 1 [ Homo sapiens (human) ]

    Gene ID: 3383, updated on 19-Sep-2021

    Summary

    Official Symbol
    ICAM1provided by HGNC
    Official Full Name
    intercellular adhesion molecule 1provided by HGNC
    Primary source
    HGNC:HGNC:5344
    See related
    Ensembl:ENSG00000090339 MIM:147840
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BB2; CD54; P3.58
    Summary
    This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in lung (RPKM 83.1), bone marrow (RPKM 40.5) and 20 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ICAM1 in Genome Data Viewer
    Location:
    19p13.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (10271120..10286615)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (10381796..10397291)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene sphingosine-1-phosphate receptor 2 Neighboring gene microRNA 4322 Neighboring gene mitochondrial ribosomal protein L4 Neighboring gene uncharacterized LOC105372272 Neighboring gene intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) Neighboring gene intercellular adhesion molecule 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Genome-wide association analysis of soluble ICAM-1 concentration reveals novel associations at the NFKBIK, PNPLA3, RELA, and SH2B3 loci.
    GeneReviews: Not available
    Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
    GeneReviews: Not available
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    GeneReviews: Not available
    Large-scale genomic studies reveal central role of ABO in sP-selectin and sICAM-1 levels.
    GeneReviews: Not available
    Novel association of ABO histo-blood group antigen with soluble ICAM-1: results of a genome-wide association study of 6,578 women.
    GeneReviews: Not available
    Susceptibility to malaria
    MedGen: C1970028 OMIM: 611162 GeneReviews: Not available
    Compare labs

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    HIV-1/HCV co-infection correlates with elevated ICAM1 and VCAM1 serum levels, which relates to disease progression PubMed
    HIV-1 infected clinical samples have plasma extracellular vesicles that contain elevated CCL1 (I309), IGFBP1, CCL5 (RANTES), GMCSF, ANG, ADIPOQ (ACRP30), CSF3 (GCSF), CXCL1 (GRO), ICAM1, IL2RA, IL6R, TNFRSF1A, and TIMP1 when compared to healthy donors PubMed
    HIV-1 (NL4-3 derived NLENG1 (enhanced green fluorescent protein, (EGFP) gene linked with internal ribosome entry site between env and nef genes)) cell-to-cell transmission from lymphocytes to astrocytes requires ICAM1 PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Cells treated with monoclonal antibodies to ICAM-1 and LFA-1 adhesion molecules show an impaired release of IFN after HIV-1 gp120 stimulation, suggesting a crucial role of cell-to-cell interactions in the process leading to IFN production PubMed
    env The interaction of CD4+ T cells with HIV-1 gp120 on bilayers triggers LFA-1 activation and the LFA-1-ICAM-1 interaction rearrangement PubMed
    env HIV-1 gp120-mediated ICAM-1 expression has functional significance, as it enhances the ability of monocytic cells to bind to gp120-stimulated human astrocytes in an ICAM-1/beta 2 integrin-dependent fashion PubMed
    env HIV-1 gp120-presenting surfaces arrest the migration of primary activated CD4 T cells that occurs spontaneously in the presence of ICAM-1 and induces the formation of a virological synapse PubMed
    env Infectivity of an HIV-1 Matrix mutant that carries a suboptimal amount of HIV-1 gp120/41 is restored to a certain degree by the presence of ICAM-1 when infection is performed in cells expressing an activated form of its natural counter-ligand, LFA-1 PubMed
    env HIV-1 gp120 enhances the expression of ICAM-1 in primary human astrocytes, glioma, and endothelial cells PubMed
    env Lck phosphorylates CD3zeta and the TCR-CD3 complex is recruited to a virological synapse (VS) when cells interact with gp120+ICAM-1 bilayers, creating an F-actin-depleted zone PubMed
    env Lck is recuited to a virological synapse (VS) interface and is highly colocalized with gp120 when cells interact with gp120+ICAM-1 bilayers, leading to activation of ZAP70, LAT, SLP76, and PLCgamma PubMed
    env HIV gp120 and TNF-alpha synergistically reduce endothelial nitric oxide synthase (eNOS) expression and cause endothelial dysfunction via ICAM-1 PubMed
    env Treatment of cells with IFN reduces HIV-1 gp120 incorporation, as well as HIV-1 envelope-mediated incorporation of ICAM-1, into virions resulting in viruses that exhibit a significantly decreased ability to become bound to CD4+ target cells PubMed
    env HIV-1 gp120 activates human brain micro vascular endothelial cells (HBMEC) via CD4 in upregulating ICAM-1 and VCAM-1 expression, IL-6 secretion and increased monocyte transmigration across monolayers PubMed
    Envelope surface glycoprotein gp160, precursor env Antibodies against cell surface molecules LFA-1, ICAM-1, HLA-DR, and CD28 inhibit the HIV-1 gp160-induced B cell differentiation response; gp160 also induces IL-6R and CD23 molecule expression on B cells PubMed
    env ICAM-1 promotes HIV-1 gp160-mediated syncytium formation, and the ICAM-1 contrareceptor LFA-1 attenuates the syncytium-inhibiting activity of virus-neutralizing monoclonal antibodies and soluble CD4 PubMed
    Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 ectodomain fragment (amino acids 550-639) upregulates ICAM-1 on the human brain micro vascular endothelial cells (HBMECs) and elicits membrane ruffling on the surface of HBMECs PubMed
    env HIV-1 gp41 selectively enhances MHC class I, ICAM-1, IFN-alpha, IFN-beta, and IFN-omega expression in H9 cells PubMed
    Nef nef Microvesicles, which contaminate purified HIV-1 inocula due to similar size and density, contain viral protein Nef and cellular proteins HSP90alpha and HSP90beta that are capable of potent stimulation of dendritic cells maturation and ICAM-1 expression PubMed
    nef Expression of HIV-1 Nef in macrophages induces the release of sICAM, which upregulates the expression of co-stimulatory receptors on B lymphocytes PubMed
    nef HIV-1 Nef increases the production of exosomes, which form at the plasma membrane and co-localizes with plasma membrane-associated proteins ICAM1, CD81, and Lck in Jurkat PubMed
    nef HIV-1 Nef upregulates ICAM-1 expression on endothelial cells via Erk /Mapk signaling pathway PubMed
    nef Monoclonal antibodies to the cell surface molecule intracellular adhesion molecule (ICAM)-1 inhibit the Nef-induced B-cell differentiation response, suggesting an interaction between Nef and ICAM-1 PubMed
    Pr55(Gag) gag The C-terminal region (amino acids 44-132) of MA is required for ICAM-1 incorporation into HIV-1 Gag virus-like particles PubMed
    gag Acquisition of host ICAM-1 by HIV-1 occurs through an interaction between the cytoplasmic tail (residues 503-523) of ICAM-1 and HIV-1 Gag PubMed
    gag HIV-1 Gag virus-like particle-induced monocyte activation is shown by upregulation of molecules involved in antigen presentation (MHC II, CD80, CD86) and cell adhesion (CD54) PubMed
    gag ICAM-1 co-localizes with the Matrix protein of HIV-1 Gag at sites of cell-to-cell membrane contact and is incorporated into virus particles PubMed
    Tat tat HIV-1 Tat upregulates ICAM1 protein expression in hCMEC/D3 cells PubMed
    tat HIV-1 Tat upregulates ICAM1 mRNA and protein expression in CRT-MG human astroglioma cells PubMed
    tat HIV-1 Tat upregulates the expression of ICAM-1 in endothelial cells and astrocytes, an effect that is in part regulated by NF-kappa B and may be associated with AIDS-related Kaposi's sarcoma PubMed
    tat Microarray analysis indicates HIV-1 Tat-induced upregulation of intercellular adhesion molecule 1 (ICAM1; CD54) in primary human brain microvascular endothelial cells PubMed
    tat HIV-1 Tat-mediated upregulation of ICAM-1 expression involves reduction of miR-221/-222 expression PubMed
    tat Inhibition of human telomerase reverse transcriptase (hTERT) results in the upregulation of HIV-1 Tat-induced overexpression of intercellular adhesion molecule-1 (ICAM1) via the nuclear factor-kappaB-regulated mechanism PubMed
    tat Cell-permeable SOD inhibits the activation of MAP kinases including ERK, JNK and p38 and the upregulation of ICAM-1 and VCAM-1 by HIV-1 Tat PubMed
    tat HIV-1 Tat-induced up-regulation of VCAM-1/ICAM-1 is blocked by NADPH oxidase inhibitor PubMed
    tat Treatment of monocytes with HIV-1 Tat increases their adhesion to endothelial monolayers, an effect that is inhibited by anti-ICAM-1 Abs, suggesting an interaction between Tat and ICAM-1 PubMed
    Vpu vpu The expression of cellular surface ICAM-1 protein increases in cells infected with vpu-deficient HIV-1 compared to cells infected with the wild-type virus, indicating that HIV-1 Vpu downregulates ICAM-1 protein expression PubMed
    capsid gag ICAM-1 is weakly incorporated into HIV-1 virions when HIV-1 CA and RT (p51/p65) are concomitantly detected in Western blot PubMed
    gag Depletion of the ICAM1 expression upregulates HIV-1 CA A92E mutant infectivity in CsA-untreated HeLa cells and downregulates its infectivity in CsA-treated HeLa cells PubMed
    matrix gag The acidic amino acids in the MA 102-114 domain and the basic amino acids in the ICAM-1 505-513 domain are required for interaction between MA and ICAM-1, leading to ICAM-1 incorporation into virus-like particles PubMed
    gag The C-terminal region (amino acids 44-132) of MA is required for ICAM-1 incorporation into HIV-1 Gag virus-like particles PubMed
    gag Treatment of human PBMCs with HIV-1 MA upregulates the expression of MCP-1, ICAM-1, CD40, CD86 and CD36 and downregulates the expression of nuclear receptors FXR and PPARgamma PubMed
    gag ICAM-1 co-localizes with HIV-1 Matrix at sites of cell-to-cell membrane contact and is incorporated into virus particles PubMed
    reverse transcriptase gag-pol ICAM-1 is weakly incorporated into HIV-1 virions when HIV-1 CA and RT (p51/p65) are concomitantly detected in Western blot PubMed
    reverse transcriptase p51 subunit gag-pol ICAM-1 is weakly incorporated into HIV-1 virions when HIV-1 CA and RT (p51/p65) are concomitantly detected in Western blot PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables integrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables integrin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables integrin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables transmembrane signaling receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables virus receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in T cell antigen processing and presentation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in T cell extravasation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in acute inflammatory response to antigenic stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in adhesion of symbiont to host IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cell adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cell adhesion mediated by integrin IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell aging IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to alkaloid IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to amyloid-beta IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to dexamethasone stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to glucose stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to interferon-gamma IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to interleukin-1 IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to interleukin-6 IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to leukemia inhibitory factor IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to nutrient levels IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to tumor necrosis factor IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in establishment of Sertoli cell barrier IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in establishment of endothelial barrier IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in establishment of endothelial intestinal barrier IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in leukocyte cell-cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in leukocyte migration IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in membrane to membrane docking IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in negative regulation of calcium ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of endothelial cell apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in ovarian follicle development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of NF-kappaB transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of actin filament polymerization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cellular extravasation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of leukocyte adhesion to vascular endothelial cell IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of nitric oxide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of peptidyl-tyrosine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of vasoconstriction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in receptor-mediated virion attachment to host cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of cell shape IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of leukocyte mediated cytotoxicity TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of ruffle assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to amino acid IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to amphetamine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to copper ion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to ethanol IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to gonadotropin IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to insulin IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to ionizing radiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to sulfur dioxide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to xenobiotic stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sensory perception of sound IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in viral entry into host cell IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    intercellular adhesion molecule 1
    Names
    ICAM-1
    cell surface glycoprotein P3.58
    epididymis secretory sperm binding protein
    intercellular adhesion molecule 1 (CD54), human rhinovirus receptor
    major group rhinovirus receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012083.1 RefSeqGene

      Range
      5280..20775
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000201.3NP_000192.2  intercellular adhesion molecule 1 precursor

      See identical proteins and their annotated locations for NP_000192.2

      Status: REVIEWED

      Source sequence(s)
      BC015969, BG149901
      Consensus CDS
      CCDS12231.1
      UniProtKB/Swiss-Prot
      P05362
      Related
      ENSP00000264832.2, ENST00000264832.8
      Conserved Domains (4) summary
      cd05755
      Location:113207
      Ig2_ICAM-1_like; Second immunoglobulin (Ig)-like domain of intercellular cell adhesion molecule-1 (ICAM-1, CD54) and similar proteins
      smart00410
      Location:404474
      IG_like; Immunoglobulin like
      pfam03921
      Location:24110
      ICAM_N; Intercellular adhesion molecule (ICAM), N-terminal domain
      cl11960
      Location:311387
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

      Range
      10271120..10286615
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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