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    Parp Poly-(ADP-ribose) polymerase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 3355109, updated on 8-Oct-2018

    Summary

    Official Symbol
    Parpprovided by FlyBase
    Official Full Name
    Poly-(ADP-ribose) polymeraseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0010247
    Locus tag
    Dmel_CG40411
    Gene type
    protein coding
    RNA name
    Poly-(ADP-ribose) polymerase
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster (old-lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BEST:LD21673; CG17685; CG17696; CG17718; CG40411; D.PARP; dARTD1; Dm.pARTa; Dmel\CG40411; dmparp; dPARP; dPARP1; LD21673.3prime; parp; PARP; PARP-1; Parp1; PARP1

    Genomic context

    See Parp in Genome Data Viewer
    Location:
    81F-81F; 3-47.1 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.13 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (3461351..3587054, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3RHet NW_001848858.1 (1935206..2026815)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Piezo-like Neighboring gene ncRNA Neighboring gene spookier Neighboring gene Apoptosis-linked gene-2 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    • Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    NAD binding IEA
    Inferred from Electronic Annotation
    more info
     
    NAD+ ADP-ribosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    NAD+ ADP-ribosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein ADP-ribosylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    Cajal body organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    chromosome organization TAS
    Traceable Author Statement
    more info
    PubMed 
    dorsal/ventral axis specification, ovarian follicular epithelium IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    double-strand break repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    heat shock-mediated polytene chromosome puffing IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    heat shock-mediated polytene chromosome puffing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    maintenance of protein location in nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    metamorphosis TAS
    Traceable Author Statement
    more info
    PubMed 
    nucleolus organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    polytene chromosome puffing TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of antibacterial peptide biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein localization to nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein ADP-ribosylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein ADP-ribosylation TAS
    Traceable Author Statement
    more info
    PubMed 
    protein poly-ADP-ribosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    rRNA transcription TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of RNA splicing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription, DNA-templated TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    Cajal body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone locus body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear euchromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleolus TAS
    Traceable Author Statement
    more info
    PubMed 
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    polytene chromosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    polytene chromosome TAS
    Traceable Author Statement
    more info
    PubMed 
    polytene chromosome puff IDA
    Inferred from Direct Assay
    more info
    PubMed 
    polytene chromosome puff TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    Poly-(ADP-ribose) polymerase
    Names
    (Poly (ADP-ribose) polymeras
    CG40411-PB
    Parp-PB
    Poly(ADP ribose) polymerase 1
    Poly(ADP)-Ribose polymerase
    Poly(ADP-)Ribose polymerase
    Poly(ADP-ribose) polymerase
    Poly(ADP-ribose) polymerase 1
    poly (ADP-ribose) polymerase
    poly ADP ribose polymerase
    poly ADP-ribose (ADPr) polymerase 1
    NP_001104452.1

    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      3461351..3587054 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001110982.3NP_001104452.1  Poly-(ADP-ribose) polymerase [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001104452.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P35875
      Related
      FBpp0112608, FBtr0113885
      Conserved Domains (6) summary
      cd08001
      Location:526629
      WGR_PARP1_like; WGR domain of poly(ADP-ribose) polymerase 1 and similar proteins
      smart00292
      Location:382454
      BRCT; breast cancer carboxy-terminal domain
      PLN03123
      Location:6992
      PLN03123; poly [ADP-ribose] polymerase; Provisional
      cd01437
      Location:645988
      parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...
      pfam00645
      Location:114193
      zf-PARP; Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
      pfam08063
      Location:270322
      PADR1; PADR1 (NUC008) domain
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