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    Dhps deoxyhypusine synthase [ Mus musculus (house mouse) ]

    Gene ID: 330817, updated on 23-May-2018

    Summary

    Official Symbol
    Dhpsprovided by MGI
    Official Full Name
    deoxyhypusine synthaseprovided by MGI
    Primary source
    MGI:MGI:2683592
    See related
    Ensembl:ENSMUSG00000060038 Vega:OTTMUSG00000031492
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dhs
    Expression
    Ubiquitous expression in ovary adult (RPKM 12.7), adrenal adult (RPKM 12.0) and 28 other tissues See more
    Orthologs

    Genomic context

    See Dhps in Genome Data Viewer
    Location:
    8; 8 C3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (85069723..85075162)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (87595656..87599060)

    Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene F-box and WD-40 domain protein 9 Neighboring gene microRNA 7070 Neighboring gene predicted gene 5741 Neighboring gene WD repeat domain containing 83 Neighboring gene WD repeat domain 83 opposite strand Neighboring gene mannosidase 2, alpha B1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Clone Names

    • MGC49129, MGC74384

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    deoxyhypusine synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    deoxyhypusine synthase activity ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    glucose homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    peptidyl-lysine modification to peptidyl-hypusine IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    peptidyl-lysine modification to peptidyl-hypusine IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    peptidyl-lysine modification to peptidyl-hypusine ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of T cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein homotetramerization ISO
    Inferred from Sequence Orthology
    more info
     
    spermidine catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    spermidine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    deoxyhypusine synthase
    NP_001034603.1
    XP_011246718.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039514.1NP_001034603.1  deoxyhypusine synthase

      See identical proteins and their annotated locations for NP_001034603.1

      Status: VALIDATED

      Source sequence(s)
      AK159104, BB763715
      Consensus CDS
      CCDS22492.1
      UniProtKB/Swiss-Prot
      Q3TXU5
      Related
      ENSMUSP00000077733.6, OTTMUSP00000041408, ENSMUST00000078665.12, OTTMUST00000078026
      Conserved Domains (1) summary
      pfam01916
      Location:45351
      DS; Deoxyhypusine synthase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

      Range
      85069723..85075162
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011248416.2XP_011246718.1  deoxyhypusine synthase isoform X1

      See identical proteins and their annotated locations for XP_011246718.1

      UniProtKB/TrEMBL
      Q811L9
      Conserved Domains (1) summary
      pfam01916
      Location:1168
      DS; Deoxyhypusine synthase

    RNA

    1. XR_001778449.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_201408.1: Suppressed sequence

      Description
      NM_201408.1: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.
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