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    Dtd2 D-tyrosyl-tRNA deacylase 2 [ Mus musculus (house mouse) ]

    Gene ID: 328092, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Dtd2provided by MGI
    Official Full Name
    D-tyrosyl-tRNA deacylase 2provided by MGI
    Primary source
    MGI:MGI:1923485
    See related
    Ensembl:ENSMUSG00000020956 AllianceGenome:MGI:1923485
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ATD; 4930578F06Rik; 6530401N04Rik; B830049N13Rik
    Summary
    Enables Ala-tRNA(Thr) hydrolase activity and D-tyrosyl-tRNA(Tyr) deacylase activity. Involved in aminoacyl-tRNA metabolism involved in translational fidelity. Predicted to be active in cytoplasm. Orthologous to human DTD2 (D-aminoacyl-tRNA deacylase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in liver E14 (RPKM 2.9), liver E18 (RPKM 2.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    12 22.11 cM; 12 C1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (52035089..52053290, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (51988306..52006507, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3051 Neighboring gene STARR-seq mESC enhancer starr_32114 Neighboring gene predicted gene, 34894 Neighboring gene HEAT repeat containing 5A Neighboring gene STARR-seq mESC enhancer starr_32115 Neighboring gene STARR-seq mESC enhancer starr_32116 Neighboring gene G protein-coupled receptor 33 Neighboring gene CD79A antigen (immunoglobulin-associated alpha) pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A chiral selectivity relaxed paralog of DTD for proofreading tRNA mischarging in Animalia. Kuncha SK, et al. Nat Commun, 2018 Feb 6. PMID 29410408, Free PMC Article
    2. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables Ala-tRNA(Thr) hydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables Ala-tRNA(Thr) hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables D-aminoacyl-tRNA deacylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables D-tyrosyl-tRNA(Tyr) deacylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables D-tyrosyl-tRNA(Tyr) deacylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminoacyl-tRNA editing activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in aminoacyl-tRNA metabolism involved in translational fidelity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in aminoacyl-tRNA metabolism involved in translational fidelity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tRNA metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    D-aminoacyl-tRNA deacylase 2
    Names
    L-alanyl-tRNA deacylase
    animalia-specifc tRNA deacylase
    animalia-specific tRNA deacylase
    probable D-tyrosyl-tRNA(Tyr) deacylase 2
    putative D-tyrosyl-tRNA deacylase 2
    putative D-tyrosyl-tRNA(Tyr) deacylase 2
    NP_001334333.1
    NP_083821.1
    XP_036013397.1
    XP_036013398.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347404.1 → NP_001334333.1  D-aminoacyl-tRNA deacylase 2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter isoform (1).
      Source sequence(s)
      AK016300, BY069987, BY423647
      Consensus CDS
      CCDS83962.1
      UniProtKB/Swiss-Prot
      Q8BHA3
      Related
      ENSMUSP00000082525.4, ENSMUST00000085404.10

    2. NM_029545.3 → NP_083821.1  D-aminoacyl-tRNA deacylase 2 isoform 2

      See identical proteins and their annotated locations for NP_083821.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) is longer and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK042771, BY069987
      Consensus CDS
      CCDS25903.1
      UniProtKB/Swiss-Prot
      Q8BHA3, Q9D363, Q9D4Q5
      Related
      ENSMUSP00000021339.8, ENSMUST00000021339.8
      Conserved Domains (1) summary
      pfam02580
      Location:12 → 167
      Tyr_Deacylase; D-Tyr-tRNA(Tyr) deacylase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      52035089..52053290 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036157504.1 → XP_036013397.1  D-aminoacyl-tRNA deacylase 2 isoform X1

      Conserved Domains (1) summary
      pfam02580
      Location:1 → 92
      Tyr_Deacylase; D-Tyr-tRNA(Tyr) deacylase

    2. XM_036157505.1 → XP_036013398.1  D-aminoacyl-tRNA deacylase 2 isoform X1

      Conserved Domains (1) summary
      pfam02580
      Location:1 → 92
      Tyr_Deacylase; D-Tyr-tRNA(Tyr) deacylase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BHA3.1 GenPept UniProtKB/Swiss-Prot:Q8BHA3

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