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    Gss1 Glutathione synthetase 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32775, updated on 28-Aug-2019

    Summary

    Official Symbol
    Gss1provided by FlyBase
    Official Full Name
    Glutathione synthetase 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0030882
    Locus tag
    Dmel_CG6835
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    6835; CG32497; CG33065; CG6835; Dmel\CG6835; GS; gss; GSS

    Genomic context

    See Gss1 in Genome Data Viewer
    Location:
    16F1-16F1; 1-59 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.26 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (17889547..17898603)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (17783580..17792636)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene minibrain Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene pseudo Neighboring gene Glutathione synthetase 2

    Genomic regions, transcripts, and products

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    • Homologs of the Gss1 gene: The Gss1 gene is conserved in human, chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.
    • Orthologs

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    glutathione binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    glutathione synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    glutathione synthase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    detoxification of arsenic-containing substance IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    glutathione biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    response to ethanol IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    glutathione synthetase 1
    Names
    CG6835-PE
    CG6835-PF
    CG6835-PG
    CG6835-PH
    CG6835-PI
    CG6835-PJ
    CG6835-PK
    Gss1-PE
    Gss1-PF
    Gss1-PG
    Gss1-PH
    Gss1-PI
    Gss1-PJ
    Gss1-PK
    glutathione synthase
    glutathione synthetase
    NP_001162782.1
    NP_001162783.1
    NP_001162784.1
    NP_001285394.1
    NP_573256.3
    NP_788925.2
    NP_788926.2

    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      17889547..17898603
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_176752.2NP_788925.2  glutathione synthetase 1, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788925.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86B44
      Related
      FBpp0290195, FBtr0300973
      Conserved Domains (1) summary
      pfam03917
      Location:20552
      GSH_synth_ATP; Eukaryotic glutathione synthase, ATP binding domain
    2. NM_001169311.1NP_001162782.1  glutathione synthetase 1, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162782.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IQZ1
      Related
      FBpp0290191, FBtr0300969
      Conserved Domains (1) summary
      pfam03917
      Location:20481
      GSH_synth_ATP; Eukaryotic glutathione synthase, ATP binding domain
    3. NM_133028.3NP_573256.3  glutathione synthetase 1, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573256.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VX03
      Related
      FBpp0290192, FBtr0300970
      Conserved Domains (1) summary
      cl00170
      Location:20124
      eu-GS; Eukaryotic Glutathione Synthetase (eu-GS); catalyses the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner. Belongs to the ATP-grasp superfamily.
    4. NM_176753.2NP_788926.2  glutathione synthetase 1, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788926.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86B44
      Related
      FBpp0290194, FBtr0300972
      Conserved Domains (1) summary
      pfam03917
      Location:20552
      GSH_synth_ATP; Eukaryotic glutathione synthase, ATP binding domain
    5. NM_001169313.1NP_001162784.1  glutathione synthetase 1, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162784.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IQZ1
      Related
      FBpp0290196, FBtr0300974
      Conserved Domains (1) summary
      pfam03917
      Location:20481
      GSH_synth_ATP; Eukaryotic glutathione synthase, ATP binding domain
    6. NM_001169312.1NP_001162783.1  glutathione synthetase 1, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162783.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q1RL06
      Related
      FBpp0290193, FBtr0300971
      Conserved Domains (1) summary
      cl00170
      Location:20232
      eu-GS; Eukaryotic Glutathione Synthetase (eu-GS); catalyses the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner. Belongs to the ATP-grasp superfamily.
    7. NM_001298465.1NP_001285394.1  glutathione synthetase 1, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285394.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JCE7
      Related
      FBpp0309327, FBtr0340369
      Conserved Domains (1) summary
      cl00170
      Location:20124
      eu-GS; Eukaryotic Glutathione Synthetase (eu-GS); catalyses the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner. Belongs to the ATP-grasp superfamily.
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