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    HPX hemopexin [ Homo sapiens (human) ]

    Gene ID: 3263, updated on 8-Jul-2018
    Official Symbol
    HPXprovided by HGNC
    Official Full Name
    hemopexinprovided by HGNC
    Primary source
    HGNC:HGNC:5171
    See related
    Ensembl:ENSG00000110169 MIM:142290; Vega:OTTHUMG00000133399
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HX
    Summary
    This gene encodes a plasma glycoprotein that binds heme with high affinity. The encoded protein is an acute phase protein that transports heme from the plasma to the liver and may be involved in protecting cells from oxidative stress. [provided by RefSeq, Apr 2009]
    Expression
    Restricted expression toward liver (RPKM 1209.1) See more
    Orthologs
    See HPX in Genome Data Viewer
    Location:
    11p15.4
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 11 NC_000011.10 (6431038..6441024, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (6452268..6462254, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene sphingomyelin phosphodiesterase 1 Neighboring gene amyloid beta precursor protein binding family B member 1 Neighboring gene tripartite motif containing 3 Neighboring gene ADP ribosylation factor interacting protein 2 Neighboring gene translocase of inner mitochondrial membrane 10B

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Binding and Uptake of Ligands by Scavenger Receptors, organism-specific biosystem (from REACTOME)
      Binding and Uptake of Ligands by Scavenger Receptors, organism-specific biosystemScavenger receptors bind free extracellular ligands as the initial step in clearance of the ligands from the body (reviewed in Ascenzi et al. 2005, Areschoug and Gordon 2009, Nielsen et al. 2010). So...
    • Scavenging of heme from plasma, organism-specific biosystem (from REACTOME)
      Scavenging of heme from plasma, organism-specific biosystemFree heme is damaging to tissues as it intercalates into biologic membranes, perturbing lipid bilayers and promoting the conversion of low-density lipoprotein to cytotoxic oxidized products. Moreover...
    • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
      Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ56652

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    heme transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    metallopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    NOT metallopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    cellular iron ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    heme metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    heme metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    heme transport IEA
    Inferred from Electronic Annotation
    more info
     
    hemoglobin metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    hemoglobin metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of humoral immune response mediated by circulating immunoglobulin IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of immunoglobulin production IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of interferon-gamma-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of tyrosine phosphorylation of STAT protein IEA
    Inferred from Electronic Annotation
    more info
     
    receptor-mediated endocytosis TAS
    Traceable Author Statement
    more info
     
    viral process IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    hemopexin
    Names
    beta-1B-glycoprotein
    NP_000604.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_000613.2NP_000604.1  hemopexin precursor

      See identical proteins and their annotated locations for NP_000604.1

      Status: REVIEWED

      Source sequence(s)
      AC084337, AK313648, AV655383, BC005395
      Consensus CDS
      CCDS7763.1
      UniProtKB/Swiss-Prot
      P02790
      UniProtKB/TrEMBL
      Q9BS19
      Related
      ENSP00000265983.3, OTTHUMP00000164583, ENST00000265983.7, OTTHUMT00000257256
      Conserved Domains (1) summary
      cd00094
      Location:47231
      HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p12 Primary Assembly

      Range
      6431038..6441024 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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