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    HOXB4 homeobox B4 [ Homo sapiens (human) ]

    Gene ID: 3214, updated on 12-Oct-2019

    Summary

    Official Symbol
    HOXB4provided by HGNC
    Official Full Name
    homeobox B4provided by HGNC
    Primary source
    HGNC:HGNC:5115
    See related
    Ensembl:ENSG00000182742 MIM:142965
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HOX2; HOX2F; HOX-2.6
    Summary
    This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Intracellular or ectopic expression of this protein expands hematopoietic stem and progenitor cells in vivo and in vitro, making it a potential candidate for therapeutic stem cell expansion. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in fat (RPKM 4.1), lung (RPKM 2.6) and 19 other tissues See more
    Orthologs

    Genomic context

    See HOXB4 in Genome Data Viewer
    Location:
    17q21.32
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    109.20190905 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (48575507..48578350, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (46652869..46655743, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 4554 Neighboring gene HOXB cluster antisense RNA 1 Neighboring gene homeobox B2 Neighboring gene homeobox B3 Neighboring gene microRNA 10a Neighboring gene HOXB cluster antisense RNA 3 Neighboring gene homeobox B5

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    anterior/posterior pattern specification IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    bone marrow development IEA
    Inferred from Electronic Annotation
    more info
     
    cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    definitive hemopoiesis IEA
    Inferred from Electronic Annotation
    more info
     
    embryonic skeletal system morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    hematopoietic stem cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    morphogenesis of an epithelial sheet IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of stem cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    skeletal system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    somatic stem cell division IEA
    Inferred from Electronic Annotation
    more info
     
    spleen development IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    centrosome IDA
    Inferred from Direct Assay
    more info
     
    nuclear chromatin ISA
    Inferred from Sequence Alignment
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    homeobox protein Hox-B4
    Names
    homeo box 2F
    homeo box B4
    homeobox protein Hox-2.6
    homeobox protein Hox-2F

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024015.5NP_076920.1  homeobox protein Hox-B4

      See identical proteins and their annotated locations for NP_076920.1

      Status: REVIEWED

      Source sequence(s)
      AC103702, AL137449, BC049204
      Consensus CDS
      CCDS11529.1
      UniProtKB/Swiss-Prot
      P17483
      Related
      ENSP00000328928.5, ENST00000332503.6
      Conserved Domains (1) summary
      pfam00046
      Location:165218
      Homeobox; Homeobox domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

      Range
      48575507..48578350 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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