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    Brwd3 bromodomain and WD repeat domain containing 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 317213, updated on 18-Apr-2019

    Summary

    Official Symbol
    Brwd3provided by RGD
    Official Full Name
    bromodomain and WD repeat domain containing 3provided by RGD
    Primary source
    RGD:1559445
    See related
    Ensembl:ENSRNOG00000002291
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1559445
    Expression
    Biased expression in Thymus (RPKM 116.7), Spleen (RPKM 38.5) and 9 other tissues See more
    Orthologs

    Genomic context

    See Brwd3 in Genome Data Viewer
    Location:
    Xq22
    Exon count:
    41
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (79817968..79909891, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) X NC_005120.3 (79993004..80086950, complement)

    Chromosome X - NC_005120.4Genomic Context describing neighboring genes Neighboring gene syntaxin-3-like Neighboring gene similar to peptidylprolyl isomerase D Neighboring gene high mobility group nucleosome binding domain 5 Neighboring gene SH3 domain binding glutamate-rich protein like

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of cell shape IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of cell shape ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    bromodomain and WD repeat-containing protein 3; LOW QUALITY PROTEIN: bromodomain and WD repeat-containing protein 3

    NCBI Reference Sequences (RefSeq)

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005120.4 Reference Rnor_6.0 Primary Assembly

      Range
      79817968..79909891 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008773357.2XP_008771579.1  LOW QUALITY PROTEIN: bromodomain and WD repeat-containing protein 3 isoform X1

      Related
      ENSRNOP00000050434.5, ENSRNOT00000050336.6
      Conserved Domains (5) summary
      cd05529
      Location:11321244
      Bromo_WDR9_I_like; Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional ...
      COG2319
      Location:175543
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:172497
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:183220
      7WD40; WD40 repeat [structural motif]
      cl02556
      Location:13031442
      Bromodomain; Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.

    Alternate Rn_Celera

    Genomic

    1. AC_000089.1 Alternate Rn_Celera

      Range
      75044717..75138705 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006227425.3XP_006227487.1  bromodomain and WD repeat-containing protein 3 isoform X2

      Conserved Domains (5) summary
      cd05529
      Location:11291241
      Bromo_WDR9_I_like; Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional ...
      COG2319
      Location:175540
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:172494
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:183220
      7WD40; WD40 repeat [structural motif]
      cl02556
      Location:13001439
      Bromodomain; Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
    2. XM_001054667.4XP_001054667.1  bromodomain and WD repeat-containing protein 3 isoform X1

      Conserved Domains (5) summary
      cd05529
      Location:11291241
      Bromo_WDR9_I_like; Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional ...
      COG2319
      Location:175540
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:172494
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:183220
      7WD40; WD40 repeat [structural motif]
      cl02556
      Location:13001439
      Bromodomain; Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
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