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    Dclk3 doublecortin-like kinase 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 316023, updated on 18-Apr-2019

    Summary

    Official Symbol
    Dclk3provided by RGD
    Official Full Name
    doublecortin-like kinase 3provided by RGD
    Primary source
    RGD:1309232
    See related
    Ensembl:ENSRNOG00000033026
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Dcamkl3; RGD1309232
    Summary
    This gene encodes a member of the protein kinase superfamily and the doublecortin family. Differently from the other two closely related family members (DCLK1 and DCLK2), the protein encoded by this gene contains only one N-terminal doublecortin domain and is unable to bind microtubules and to regulate microtubule polymerization. The protein contains a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmoduline-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. [provided by RefSeq, Sep 2010]
    Expression
    Biased expression in Kidney (RPKM 135.7), Brain (RPKM 57.6) and 3 other tissues See more
    Orthologs

    Genomic context

    See Dclk3 in Genome Data Viewer
    Location:
    8q32
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (119691567..119744484)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 8 NC_005107.3 (119040830..119093605)

    Chromosome 8 - NC_005107.4Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat and ankyrin repeat containing 1 Neighboring gene uncharacterized LOC102552801 Neighboring gene uncharacterized LOC102552712 Neighboring gene uncharacterized LOC102552650 Neighboring gene uncharacterized LOC108351782 Neighboring gene SH3 and cysteine rich domain

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Process Evidence Code Pubs
    intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of protein localization to nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of protein localization to nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    serine/threonine-protein kinase DCLK3
    Names
    doublecortin and CaM kinase-like 3
    NP_001178729.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191800.1NP_001178729.1  serine/threonine-protein kinase DCLK3

      Status: VALIDATED

      Source sequence(s)
      AABR07071517, AABR07071518
      UniProtKB/TrEMBL
      F1LWF2
      Related
      ENSRNOP00000046063.4, ENSRNOT00000044742.5
      Conserved Domains (3) summary
      smart00220
      Location:515772
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl00155
      Location:92177
      UBQ; Ubiquitin-like proteins
      cl21453
      Location:514771
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005107.4 Reference Rnor_6.0 Primary Assembly

      Range
      119691567..119744484
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000076.1 Alternate Rn_Celera

      Range
      110683369..110735326
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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