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    Gsdmd gasdermin D [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315084, updated on 18-Apr-2019

    Summary

    Official Symbol
    Gsdmdprovided by RGD
    Official Full Name
    gasdermin Dprovided by RGD
    Primary source
    RGD:1307261
    See related
    Ensembl:ENSRNOG00000007728
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gsdmdc1
    Expression
    Biased expression in Thymus (RPKM 115.2), Liver (RPKM 105.4) and 9 other tissues See more
    Orthologs

    Genomic context

    See Gsdmd in Genome Data Viewer
    Location:
    7q34
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (116889147..116894134)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 7 NC_005106.3 (116781947..116786875)

    Chromosome 7 - NC_005106.4Genomic Context describing neighboring genes Neighboring gene MAF bZIP transcription factor A Neighboring gene zinc finger CCCH type containing 3 Neighboring gene maestro heat-like repeat family member 6 Neighboring gene nicotinate phosphoribosyltransferase

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    cardiolipin binding IEA
    Inferred from Electronic Annotation
    more info
     
    cardiolipin binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    phosphatidic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidic acid binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    phosphatidylinositol-4,5-bisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phosphatidylinositol-4,5-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    phosphatidylinositol-4-phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phosphatidylinositol-4-phosphate binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    phosphatidylserine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phosphatidylserine binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Process Evidence Code Pubs
    cellular response to extracellular stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to extracellular stimulus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cytolysis IEA
    Inferred from Electronic Annotation
    more info
     
    cytolysis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    defense response to Gram-negative bacterium IEA
    Inferred from Electronic Annotation
    more info
     
    defense response to Gram-negative bacterium ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    defense response to Gram-positive bacterium IEA
    Inferred from Electronic Annotation
    more info
     
    defense response to Gram-positive bacterium ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    pore complex assembly IEA
    Inferred from Electronic Annotation
    more info
     
    pore complex assembly ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    pore formation in membrane of other organism IEA
    Inferred from Electronic Annotation
    more info
     
    pore formation in membrane of other organism ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of interleukin-1 beta secretion IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of interleukin-1 beta secretion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein homooligomerization IEA
    Inferred from Electronic Annotation
    more info
     
    protein homooligomerization ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    pyroptosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    pyroptosis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Component Evidence Code Pubs
    NLRP3 inflammasome complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    NLRP3 inflammasome complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    gasdermin-D
    Names
    gasdermin domain containing 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130553.1NP_001124025.1  gasdermin-D

      See identical proteins and their annotated locations for NP_001124025.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473950
      Conserved Domains (1) summary
      pfam04598
      Location:4423
      Gasdermin; Gasdermin family

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005106.4 Reference Rnor_6.0 Primary Assembly

      Range
      116889147..116894134
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006241809.3XP_006241871.1  gasdermin-D isoform X1

      See identical proteins and their annotated locations for XP_006241871.1

      UniProtKB/TrEMBL
      A0A096MJ11
      Related
      ENSRNOP00000067951.1, ENSRNOT00000075917.1
      Conserved Domains (1) summary
      pfam04598
      Location:4460
      Gasdermin; Gasdermin family

    Alternate Rn_Celera

    Genomic

    1. AC_000075.1 Alternate Rn_Celera

      Range
      103902119..103906706
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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