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    Slc24a4 solute carrier family 24 member 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314396, updated on 2-Oct-2018

    Summary

    Official Symbol
    Slc24a4provided by RGD
    Official Full Name
    solute carrier family 24 member 4provided by RGD
    Primary source
    RGD:1305926
    See related
    Ensembl:ENSRNOG00000006729
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Nckx4
    Expression
    Biased expression in Brain (RPKM 23.4), Lung (RPKM 22.9) and 5 other tissues See more
    Orthologs

    Genomic context

    See Slc24a4 in Genome Data Viewer
    Location:
    6q32
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (126015799..126158727)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 6 NC_005105.3 (135226112..135364945)

    Chromosome 6 - NC_005105.4Genomic Context describing neighboring genes Neighboring gene protein LLP homolog Neighboring gene NADH:ubiquinone oxidoreductase subunit B1 Neighboring gene cleavage and polyadenylation specific factor 2 Neighboring gene Ras and Rab interactor 3 Neighboring gene uncharacterized LOC103692692 Neighboring gene legumain

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    calcium, potassium:sodium antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    calcium, potassium:sodium antiporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    amelogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    biological_process ND
    No biological Data available
    more info
     
    calcium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    calcium ion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular calcium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cellular calcium ion homeostasis IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    sensory perception of smell IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    sensory perception of smell ISO
    Inferred from Sequence Orthology
    more info
     
    sodium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cellular_component ND
    No biological Data available
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    sodium/potassium/calcium exchanger 4
    Names
    solute carrier family 24 (sodium/potassium/calcium exchanger), member 4

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108051.1NP_001101521.1  sodium/potassium/calcium exchanger 4

      See identical proteins and their annotated locations for NP_001101521.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473982
      UniProtKB/TrEMBL
      A0A0G2K0U1
      Related
      ENSRNOP00000071582.1, ENSRNOT00000088089.1
      Conserved Domains (2) summary
      TIGR00367
      Location:1346
      TIGR00367; K+-dependent Na+/Ca+ exchanger related-protein
      pfam01699
      Location:200352
      Na_Ca_ex; Sodium/calcium exchanger protein

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005105.4 Reference Rnor_6.0 Primary Assembly

      Range
      126015799..126158727
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006240471.3XP_006240533.1  sodium/potassium/calcium exchanger 4 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K3S9
      Related
      ENSRNOP00000072760.1, ENSRNOT00000089840.1
      Conserved Domains (2) summary
      TIGR00367
      Location:102598
      TIGR00367; K+-dependent Na+/Ca+ exchanger related-protein
      pfam01699
      Location:452604
      Na_Ca_ex; Sodium/calcium exchanger protein
    2. XM_006240472.3XP_006240534.1  sodium/potassium/calcium exchanger 4 isoform X2

      Conserved Domains (2) summary
      TIGR00367
      Location:102579
      TIGR00367; K+-dependent Na+/Ca+ exchanger related-protein
      pfam01699
      Location:433585
      Na_Ca_ex; Sodium/calcium exchanger protein

    Alternate Rn_Celera

    Genomic

    1. AC_000074.1 Alternate Rn_Celera

      Range
      118769531..118903571
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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