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    E2f6 E2F transcription factor 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313978, updated on 18-Apr-2019

    Summary

    Official Symbol
    E2f6provided by RGD
    Official Full Name
    E2F transcription factor 6provided by RGD
    Primary source
    RGD:631412
    See related
    Ensembl:ENSRNOG00000004449
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    mouse homolog is a transcription factor; involved in the regulation of cell cycle progression [RGD, Feb 2006]
    Expression
    Biased expression in Muscle (RPKM 503.6), Heart (RPKM 498.5) and 9 other tissues See more
    Orthologs

    Genomic context

    See E2f6 in Genome Data Viewer
    Location:
    6q16
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (42092513..42108692)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 6 NC_005105.3 (51811952..51828133)

    Chromosome 6 - NC_005105.4Genomic Context describing neighboring genes Neighboring gene neurotensin receptor 2 Neighboring gene growth regulating estrogen receptor binding 1 Neighboring gene Rho-associated coiled-coil containing protein kinase 2 Neighboring gene PQ loop repeat containing 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Cell cycle, organism-specific biosystem (from WikiPathways)
      Cell cycle, organism-specific biosystem(From http://en.wikipedia.org/wiki/Cell_cycle) The cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle in...
    • G1 to S cell cycle control, organism-specific biosystem (from WikiPathways)
      G1 to S cell cycle control, organism-specific biosystemIn the G1 phase there are two types of DNA damage responses, the p53-dependent and the p53-independent pathways. The p53-dependent responses inhibit CDKs through the up-regulation of genes encoding C...

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    DNA binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    DNA-binding transcription repressor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    RNA polymerase II regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to RNA polymerase II regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transcription factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    MLL1 complex IEA
    Inferred from Electronic Annotation
    more info
     
    MLL1 complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    RNA polymerase II transcription factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    RNA polymerase II transcription factor complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100717.1NP_001094187.1  transcription factor E2F6

      Status: VALIDATED

      Source sequence(s)
      AABR07063692, AY211263, CN543704, DV718285, EV774540
      UniProtKB/TrEMBL
      D4ACR8, Q80ZB0
      Related
      ENSRNOP00000057241.3, ENSRNOT00000060499.4
      Conserved Domains (2) summary
      cd14660
      Location:139239
      E2F_DD; Dimerization domain of E2F transcription factors
      pfam02319
      Location:65128
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005105.4 Reference Rnor_6.0 Primary Assembly

      Range
      42092513..42108692
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006239913.3XP_006239975.1  transcription factor E2F6 isoform X1

      Conserved Domains (2) summary
      cd14660
      Location:104204
      E2F_DD; Dimerization domain of E2F transcription factors
      pfam02319
      Location:3093
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain

    Alternate Rn_Celera

    Genomic

    1. AC_000074.1 Alternate Rn_Celera

      Range
      38900917..38917081
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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