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    Cops5 COP9 signalosome subunit 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 312916, updated on 19-Apr-2019

    Summary

    Official Symbol
    Cops5provided by RGD
    Official Full Name
    COP9 signalosome subunit 5provided by RGD
    Primary source
    RGD:1310301
    See related
    Ensembl:ENSRNOG00000006499
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Expression
    Biased expression in Muscle (RPKM 529.0), Testes (RPKM 471.8) and 9 other tissues See more
    Orthologs

    Genomic context

    See Cops5 in Genome Data Viewer
    Location:
    5q11
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (8876090..8894345)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 5 NC_005104.3 (13684111..13702378)

    Chromosome 5 - NC_005104.4Genomic Context describing neighboring genes Neighboring gene carboxypeptidase A6 Neighboring gene ADP ribosylation factor guanine nucleotide exchange factor 1 Neighboring gene centrosome and spindle pole associated protein 1 Neighboring gene protein phosphatase 1, regulatory subunit 42 Neighboring gene transcription factor 24

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC112728

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    NEDD8-specific protease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enzyme binding IEA
    Inferred from Electronic Annotation
    more info
     
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    macrophage migration inhibitory factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    macrophage migration inhibitory factor binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metallopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    metallopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    thiol-dependent ubiquitin-specific protease activity IEA
    Inferred from Electronic Annotation
    more info
     
    thiol-dependent ubiquitin-specific protease activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Process Evidence Code Pubs
    exosomal secretion IEA
    Inferred from Electronic Annotation
    more info
     
    exosomal secretion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein deneddylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein deneddylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein deubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    protein deubiquitination ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of IRE1-mediated unfolded protein response IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of IRE1-mediated unfolded protein response ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of JNK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Component Evidence Code Pubs
    COP9 signalosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    COP9 signalosome ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    chromatin IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with chromatin ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    synaptic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    COP9 signalosome complex subunit 5
    Names
    COP9 (constitutive photomorphogenic) homolog, subunit 5

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025695.1NP_001020866.1  COP9 signalosome complex subunit 5

      See identical proteins and their annotated locations for NP_001020866.1

      Status: PROVISIONAL

      Source sequence(s)
      BC098736
      UniProtKB/TrEMBL
      Q4KM69
      Related
      ENSRNOP00000008877.5, ENSRNOT00000008877.6
      Conserved Domains (1) summary
      cd08069
      Location:44314
      MPN_RPN11_CSN5; Mov34/MPN/PAD-1 family: proteasomal regulatory protein Rpn11 and signalosome complex subunit CSN5

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005104.4 Reference Rnor_6.0 Primary Assembly

      Range
      8876090..8894345
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006237758.3XP_006237820.1  COP9 signalosome complex subunit 5 isoform X1

      Conserved Domains (1) summary
      cd08069
      Location:33297
      MPN_RPN11_CSN5; Mov34/MPN/PAD-1 family: proteasomal regulatory protein Rpn11 and signalosome complex subunit CSN5

    Alternate Rn_Celera

    Genomic

    1. AC_000073.1 Alternate Rn_Celera

      Range
      8703366..8721421
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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