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    Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311860, updated on 2-Oct-2018

    Summary

    Official Symbol
    Abl1provided by RGD
    Official Full Name
    ABL proto-oncogene 1, non-receptor tyrosine kinaseprovided by RGD
    Primary source
    RGD:1584969
    See related
    Ensembl:ENSRNOG00000047356
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Abl
    Expression
    Biased expression in Kidney (RPKM 105.7), Lung (RPKM 94.8) and 9 other tissues See more
    Orthologs

    Genomic context

    See Abl1 in Genome Data Viewer
    Location:
    3p12
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (10041820..10145076, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 3 NC_005102.3 (15401182..15504438, complement)

    Chromosome 3 - NC_005102.4Genomic Context describing neighboring genes Neighboring gene fibrinogen C domain containing 1-like 1 Neighboring gene pyroglutamylated RFamide peptide Neighboring gene exosome component 2 Neighboring gene PR/SET domain 12

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    SH2 domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    SH3 domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    actin filament binding ISO
    Inferred from Sequence Orthology
    more info
     
    delta-catenin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ephrin receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    manganese ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    mitogen-activated protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    neuropilin binding ISO
    Inferred from Sequence Orthology
    more info
     
    non-membrane spanning protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    non-membrane spanning protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    phosphotyrosine residue binding ISO
    Inferred from Sequence Orthology
    more info
     
    proline-rich region binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein C-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase C binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    syntaxin binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    B cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    B cell proliferation involved in immune response ISO
    Inferred from Sequence Orthology
    more info
     
    B cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    B-1 B cell homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    Bergmann glial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    DNA damage induced protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    actin filament branching ISO
    Inferred from Sequence Orthology
    more info
     
    actin filament polymerization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    activated T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    activation of protein kinase C activity ISO
    Inferred from Sequence Orthology
    more info
     
    alpha-beta T cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    associative learning IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cardiovascular system development ISO
    Inferred from Sequence Orthology
    more info
     
    cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cellular response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to hydrogen peroxide ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to oxidative stress IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to transforming growth factor beta stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cerebellum morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    collateral sprouting ISO
    Inferred from Sequence Orthology
    more info
     
    endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    epidermal growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    establishment of protein localization ISO
    Inferred from Sequence Orthology
    more info
     
    glomerular visceral epithelial cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    integrin-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    learning or memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    microspike assembly ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of BMP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of I-kappaB kinase/NF-kappaB signaling ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cellular senescence ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of endothelial cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of long-term synaptic potentiation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of phospholipase C activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    neural tube closure ISO
    Inferred from Sequence Orthology
    more info
     
    neuroepithelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    neuromuscular process controlling balance ISO
    Inferred from Sequence Orthology
    more info
     
    neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    neuropilin signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    peptidyl-tyrosine autophosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    peptidyl-tyrosine autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    phagocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    platelet-derived growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    platelet-derived growth factor receptor-beta signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation blood vessel branching ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of I-kappaB kinase/NF-kappaB signaling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of Wnt signaling pathway, planar cell polarity pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of actin cytoskeleton reorganization ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of actin filament binding ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell migration involved in sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of dendrite development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of extracellular matrix organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of fibroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of focal adhesion assembly ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of hydrogen peroxide-mediated programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of interferon-gamma secretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of interleukin-2 secretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of microtubule binding ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of neuron death IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of neuron death ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of osteoblast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of oxidoreductase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of release of sequestered calcium ion into cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of substrate adhesion-dependent cell spreading ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of vasoconstriction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    post-embryonic development ISO
    Inferred from Sequence Orthology
    more info
     
    protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of Cdc42 protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of T cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of axon extension ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cellular senescence ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of extracellular matrix organization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of microtubule polymerization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of modification of synaptic structure IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of modification of synaptic structure ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    response to drug IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to endoplasmic reticulum stress IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to epinephrine IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    signal transduction in response to DNA damage ISO
    Inferred from Sequence Orthology
    more info
     
    spleen development ISO
    Inferred from Sequence Orthology
    more info
     
    substrate adhesion-dependent cell spreading ISO
    Inferred from Sequence Orthology
    more info
     
    thymus development ISO
    Inferred from Sequence Orthology
    more info
     
    transitional one stage B cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    cell leading edge ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    growth cone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    ruffle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    tyrosine-protein kinase ABL1
    Names
    Abelson murine leukemia viral (v-abl) oncogene homolog 1
    c-abl oncogene 1, non-receptor tyrosine kinase
    c-abl oncogene 1, receptor tyrosine kinase
    v-abl Abelson murine leukemia viral oncogene 1
    NP_001094320.1
    XP_006233980.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100850.1NP_001094320.1  tyrosine-protein kinase ABL1

      See identical proteins and their annotated locations for NP_001094320.1

      Status: VALIDATED

      Source sequence(s)
      AABR07072853
      UniProtKB/TrEMBL
      E9PT20
      Related
      ENSRNOP00000044534.3, ENSRNOT00000042495.5
      Conserved Domains (5) summary
      smart00808
      Location:10191143
      FABD; F-actin binding domain (FABD)
      cd09935
      Location:142235
      SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
      cd11850
      Location:84137
      SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
      cd05052
      Location:254516
      PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
      pfam07714
      Location:261512
      Pkinase_Tyr; Protein tyrosine kinase

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005102.4 Reference Rnor_6.0 Primary Assembly

      Range
      10041820..10145076 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006233918.3XP_006233980.1  tyrosine-protein kinase ABL1 isoform X1

      See identical proteins and their annotated locations for XP_006233980.1

      UniProtKB/TrEMBL
      D3ZGM3
      Conserved Domains (5) summary
      smart00808
      Location:10001124
      FABD; F-actin binding domain (FABD)
      cd09935
      Location:123216
      SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
      cd11850
      Location:65118
      SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
      cd05052
      Location:235497
      PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
      pfam07714
      Location:242493
      Pkinase_Tyr; Protein tyrosine kinase

    Alternate Rn_Celera

    Genomic

    1. NW_001091907.1 Alternate Rn_Celera

      Range
      3639..4535 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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