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    Pacsin3 protein kinase C and casein kinase substrate in neurons 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311187, updated on 2-Oct-2018

    Summary

    Official Symbol
    Pacsin3provided by RGD
    Official Full Name
    protein kinase C and casein kinase substrate in neurons 3provided by RGD
    Primary source
    RGD:1307327
    See related
    Ensembl:ENSRNOG00000014204
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    SdpIII
    Expression
    Biased expression in Muscle (RPKM 626.4), Heart (RPKM 232.1) and 5 other tissues See more
    Orthologs

    Genomic context

    See Pacsin3 in Genome Data Viewer
    Location:
    3q24
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (80072425..80081058)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 3 NC_005102.3 (86780541..86789813)

    Chromosome 3 - NC_005102.4Genomic Context describing neighboring genes Neighboring gene acid phosphatase 2, lysosomal Neighboring gene damage specific DNA binding protein 2 Neighboring gene similar to hypothetical protein MGC40841; similar to hypothetical protein MGC4707 Neighboring gene ADP-ribosylation factor GTPase activating protein 2 Neighboring gene LDL receptor related protein 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    calcium channel inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    calcium channel inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    cytoskeletal protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoskeletal protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    lipid binding ISO
    Inferred from Sequence Orthology
    more info
     
    phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of calcium ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane tubulation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane tubulation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of membrane protein ectodomain proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of membrane protein ectodomain proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    NOT trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    protein kinase C and casein kinase substrate in neurons protein 3
    Names
    syndapin III

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009966.2NP_001009966.1  protein kinase C and casein kinase substrate in neurons protein 3

      See identical proteins and their annotated locations for NP_001009966.1

      Status: PROVISIONAL

      Source sequence(s)
      BC100636
      UniProtKB/TrEMBL
      Q5I2Z0
      Related
      ENSRNOP00000054003.4, ENSRNOT00000057176.4
      Conserved Domains (2) summary
      cd11997
      Location:365420
      SH3_PACSIN3; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 3 (PACSIN3)
      cl12013
      Location:16273
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005102.4 Reference Rnor_6.0 Primary Assembly

      Range
      80072425..80081058
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006234510.3XP_006234572.1  protein kinase C and casein kinase substrate in neurons protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006234572.1

      UniProtKB/TrEMBL
      G3V9N7
      Related
      ENSRNOP00000070437.1, ENSRNOT00000080266.1
      Conserved Domains (2) summary
      cd11997
      Location:365420
      SH3_PACSIN3; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 3 (PACSIN3)
      cl12013
      Location:16273
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    2. XM_006234511.3XP_006234573.1  protein kinase C and casein kinase substrate in neurons protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006234573.1

      UniProtKB/TrEMBL
      G3V9N7
      Conserved Domains (2) summary
      cd11997
      Location:365420
      SH3_PACSIN3; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 3 (PACSIN3)
      cl12013
      Location:16273
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    Alternate Rn_Celera

    Genomic

    1. AC_000071.1 Alternate Rn_Celera

      Range
      76433959..76442528
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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