Format

Send to:

Choose Destination
    • Showing Current items.

    Lama3 laminin subunit alpha 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307582, updated on 9-Oct-2018

    Summary

    Official Symbol
    Lama3provided by RGD
    Official Full Name
    laminin subunit alpha 3provided by RGD
    Primary source
    RGD:628776
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    alpha chain of laminin 5 which is a structural component of hemidesmosomes that may be involved in assembly and integrity of hemidesmosomes [RGD, Feb 2006]
    Expression
    Biased expression in Lung (RPKM 161.0), Thymus (RPKM 49.3) and 7 other tissues See more
    Orthologs

    Genomic context

    See Lama3 in Genome Data Viewer
    Location:
    18p13
    Exon count:
    75
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (3704866..3941215)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 18 NC_005117.3 (3712673..3939550)

    Chromosome 18 - NC_005117.4Genomic Context describing neighboring genes Neighboring gene AKT interacting protein-like Neighboring gene NPC intracellular cholesterol transporter 1 Neighboring gene ankyrin repeat domain 29 Neighboring gene ATP synthase subunit g, mitochondrial-like Neighboring gene tetratricopeptide repeat domain 39C Neighboring gene calcium binding tyrosine phosphorylation regulated

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    cell-cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    endodermal cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    hemidesmosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    basement membrane ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with basement membrane ISO
    Inferred from Sequence Orthology
    more info
     
    cell-cell adherens junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    hemidesmosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    laminin-3 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    laminin-5 complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    laminin subunit alpha-3; LOW QUALITY PROTEIN: laminin subunit alpha-3
    Names
    laminin 5 alpha 3
    laminin, alpha 3

    NCBI Reference Sequences (RefSeq)

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005117.4 Reference Rnor_6.0 Primary Assembly

      Range
      3704866..3941215
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017601153.1XP_017456642.1  LOW QUALITY PROTEIN: laminin subunit alpha-3 isoform X1

    Alternate Rn_Celera

    Genomic

    1. AC_000086.1 Alternate Rn_Celera

      Range
      3569544..3806888
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_003753026.4XP_003753074.1  laminin subunit alpha-3 isoform X2

      Conserved Domains (9) summary
      smart00136
      Location:42293
      LamNT; Laminin N-terminal domain (domain VI)
      smart00281
      Location:15111640
      LamB; Laminin B domain
      smart00282
      Location:24342569
      LamG; Laminin G domain
      cd00055
      Location:531573
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd00110
      Location:31583309
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00053
      Location:12651313
      Laminin_EGF; Laminin EGF domain
      pfam06008
      Location:18442103
      Laminin_I; Laminin Domain I
      pfam06009
      Location:22872415
      Laminin_II; Laminin Domain II
      cl02488
      Location:19712186
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    2. XM_008774089.2XP_008772311.1  laminin subunit alpha-3 isoform X3

      See identical proteins and their annotated locations for XP_008772311.1

      Conserved Domains (6) summary
      smart00282
      Location:826961
      LamG; Laminin G domain
      cd00055
      Location:77123
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd00110
      Location:15501701
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam06008
      Location:236495
      Laminin_I; Laminin Domain I
      pfam06009
      Location:679807
      Laminin_II; Laminin Domain II
      cl02488
      Location:363578
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_173306.1: Suppressed sequence

      Description
      NM_173306.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from human: LAMA3 (GeneID:3909).
    Support Center